Articles
Michel Record, Mehdi Attia, Kevin Carayon, Laly Pucheu, Julio Bunay, Régis Soulès, Silia Ayadi, Bruno Payré, Laure Perrin-Cocon, Florence Bourgailh, Antonin Lamazière, Vincent Lotteau, Marc Poirot, Sandrine Silvente-Poirot, Philippe de Medina. Journal of Extracellular Vesicles, Volume 11 (4), April 2022, e12211.
Bertrand Boson, Chloé Mialon, Konstanze Schichl, Solène Denolly, François-Loïc Cosset. mBio https://doi.org/10.1128/mbio.02923-21
by X.Charmetant, M.Espi (...) and O.Thaunat, American Journal of Tranplantation 2022, DOI : 10.1111/ajt.16990
by X.Charmetant, M.Espi (...) and O.Thaunat, Science Translational Medicine 2022 DOI : 10.1126/scitranslmed.abl6141
The team describes glucokinase activation by the NS5A protein of Hepatitis C Virus in hepatocytes, resulting in glycolysis enhancement, leading to lipogenesis, intracellular steatosis and VLDL secretion.
Verrier et al., Antiviral Research, 2022 / Team HepVir
Guillemot et al. 2022. Virulence. doi: 10.1080/21505594.2021.2022861
Delphin et al., Viruses, 2022 / Team HepVir
Michelet, Alfaiate, Chardès et al., J Hep Reports, 2022 / Team HepVir
Pozzeto et al. Nature. December 2021
Vaccine
Check out our new preprint in BioRxiv by Flora and colleagues on the discovery of novel activators of the pyrin inflammasome.
by M.Espi, X.Charmetant (...) and O.Thaunat, Kidney International 2021, DOI : 10.1016/j.kint.2021.10.040
Travel Med Infect Dis.
Espi M, Charmetant X, et al, Kid Int 2021
C. Allam et al. Emerging Infectious Diseases Volume 27, Number 11—November 2021
Lucifora, Pastor et al., JHep Reports, 2021 / Team HepVir
ALPK1 is a kinase sensing a bacterial metabolite from the LPS biosynthesis pathway. Our favorite clinician describes a new family of patients. This rare monogenic disease associated with vision loss is still poorly known in the field of autoinflammation and this description of a new family of patients should raise awareness on the inflammatory symptoms associated with this disease.
Unreported control of Type 4 secretion by the second messenger c-di-GMP signaling is revealed
Prognostic factors of severe community-acquired staphylococcal pneumonia in France
During liver carcinogenesis, the first enzyme of glycolysis GCK is replaced in hepatocytes by the hexokinase HK2. We show that it critically contributes to metabolic reprogramming and inhibition of innate immunity associated to liver cancer development.