Articles

Aug 08, 2022 Measles Virus-Imposed Remodeling of the Autophagy Machinery Determines the Outcome of Bacterial Coinfection

Claviere M, Lavedrine A, Lamiral G, Bonnet M, Verlhac P, Petkova DS, Espert L, Duclaux-Loras R, Lucifora J, Rivoire M, Boschetti G, Nancey S, Rozières A, Viret C, Faure M. Autophagy. 2022 Jul 28.

Jul 29, 2022 Insights on the antiviral mechanisms of action of the TLR1/2 agonist Pam3CSK4 in hepatitis B virus (HBV)-infected hepatocytes

Desmares et al., Antiviral Research, 2022 / Team HepVir

Jul 12, 2022 The broad viral inhibitors IFITMs can regulate Golgi trafficking

Li Zhong, Yuxin Song, Federico Marziali, Rustem Uzbekov, Xuan-Nhi Nguyen, Chloé Journo, Philippe Roingeard, Andrea Cimarelli

Jul 11, 2022 Alteration of microbiota antibody-mediated immune selection contributes to dysbiosis in Inflammatory Bowel Diseases

Eva Michaud, Louis Waeckel, Rémi Gayet, Roman Goguyer-Deschaumes, Blandine Chanut, Fabienne Jospin, Katell Bathany, Magali Monnoye, Coraline Genet, Amelie Prier, Caroline Tokarski, Philippe Gérard, Xavier Roblin, Nicolas Rochereau, Stéphane Paul. Embo Molecular Medicine. https://www.embopress.org/doi/full/10.15252/emmm.202115386

Apr 13, 2022 Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome-enriched vesicles.

Michel Record, Mehdi Attia, Kevin Carayon, Laly Pucheu, Julio Bunay, Régis Soulès, Silia Ayadi, Bruno Payré, Laure Perrin-Cocon, Florence Bourgailh, Antonin Lamazière, Vincent Lotteau, Marc Poirot, Sandrine Silvente-Poirot, Philippe de Medina. Journal of Extracellular Vesicles, Volume 11 (4), April 2022, e12211.

Mar 10, 2022 A new mechanism for perversion of the viro-induced nuclear pore

Bertrand Boson, Chloé Mialon, Konstanze Schichl, Solène Denolly, François-Loïc Cosset. mBio https://doi.org/10.1128/mbio.02923-21

Feb 04, 2022 Predictive factors of a viral neutralizing humoral response after a third dose of COVID-19 mRNA vaccine in kidney transplant recipients

by X.Charmetant, M.Espi (...) and O.Thaunat, American Journal of Tranplantation 2022, DOI : 10.1111/ajt.16990

Feb 01, 2022 Infection or a third dose of mRNA vaccine elicits neutralizing antibody responses against SARS-CoV-2 in kidney transplant recipients

by X.Charmetant, M.Espi (...) and O.Thaunat, Science Translational Medicine 2022 DOI : 10.1126/scitranslmed.abl6141

Jan 21, 2022 Domain 2 of Hepatitis C Virus Protein NS5A Activates Glucokinase and Induces Lipogenesis in Hepatocytes

The team describes glucokinase activation by the NS5A protein of Hepatitis C Virus in hepatocytes, resulting in glycolysis enhancement, leading to lipogenesis, intracellular steatosis and VLDL secretion.

Jan 20, 2022 Loss of hepatitis D virus infectivity upon farnesyl transferase inhibitor treatment associates with increasing RNA editing rates revealed by a new RT-ddPCR method

Verrier et al., Antiviral Research, 2022 / Team HepVir

Jan 19, 2022 TNF-α response in macrophages depends on clinical Legionella pneumophila isolates genotypes.

Guillemot et al. 2022. Virulence. doi: 10.1080/21505594.2021.2022861

Jan 04, 2022 Inhibitory Effect of IL-1b on HBV and HDV Replication and HBs Antigen-Dependent Modulation of Its Secretion by Macrophages

Delphin et al., Viruses, 2022 / Team HepVir

Dec 26, 2021 Inducers of the NF-κB pathways impair Hepatitis Delta virus (HDV) replication & strongly decrease progeny infectivity in vitro

Michelet, Alfaiate, Chardès et al., J Hep Reports, 2022 / Team HepVir

Dec 23, 2021 Immunogenicity and efficacy of heterologous ChAdOx1–BNT162b2 vaccination

Pozzeto et al. Nature. December 2021

COVID-19 vaccine is correlated with favourable epidemiological indicators in the Auvergne-Rhône-Alpes region (France): An ecological study

Vaccine

Nov 12, 2021 New preprint on the pyrin inflammasome

Check out our new preprint in BioRxiv by Flora and colleagues on the discovery of novel activators of the pyrin inflammasome.

Nov 01, 2021 A prospective observational study for justification, safety, and efficacy of a third dose of mRNA vaccine in patients receiving maintenance hemodialysis

by M.Espi, X.Charmetant (...) and O.Thaunat, Kidney International 2021, DOI : 10.1016/j.kint.2021.10.040

Experience from five Asia-Pacific countries during the first wave of the COVID-19 pandemic: Mitigation strategies and epidemiology outcomes

Travel Med Infect Dis.

Sep 14, 2021 Nature communications : last LYACTS team publication

Sep 08, 2021 The ROMANOV study found impaired humoral and cellular immune responses to SARS-CoV-2 mRNA vaccine in virus-unexposed patients receiving maintenance hemodialysis

Espi M, Charmetant X, et al, Kid Int 2021

Co-infection with Legionella and SARS-CoV-2, France, March 2020

C. Allam et al. Emerging Infectious Diseases Volume 27, Number 11—November 2021

Aug 09, 2021 JEM, 2021, August 06 :Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs

Evidence for long-term association of virion-delivered Hepatitis B virus Core protein with cccDNA independently of viral protein production

Lucifora, Pastor et al., JHep Reports, 2021 / Team HepVir

Jul 07, 2021 A breath of humanity in the era of Covid-19 vaccine

Jun 24, 2021 Nipah virus W protein harnesses nuclear 14-3-3 to inhibit NF-κB-induced proinflammatory response

ALPK1 gene mutations drive autoinflammation with ectodermal dysplasia and progressive vision loss

ALPK1 is a kinase sensing a bacterial metabolite from the LPS biosynthesis pathway. Our favorite clinician describes a new family of patients. This rare monogenic disease associated with vision loss is still poorly known in the field of autoinflammation and this description of a new family of patients should raise awareness on the inflammatory symptoms associated with this disease.

Science Translational Medicine: UBIVE publication on Lassa fever vaccine

May 25, 2021 Science Immunology : LYACTS team publication on MIS-C syndrome

May 09, 2021 The Journal of Immunology : last publication LYACTS team

Deciphering Legionella effector delivery by Icm/Dot secretion system reveals a new role for c-diGMP signaling

Unreported control of Type 4 secretion by the second messenger c-di-GMP signaling is revealed

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