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Aug 08, 2022 Measles Virus-Imposed Remodeling of the Autophagy Machinery Determines the Outcome of Bacterial Coinfection

Claviere M, Lavedrine A, Lamiral G, Bonnet M, Verlhac P, Petkova DS, Espert L, Duclaux-Loras R, Lucifora J, Rivoire M, Boschetti G, Nancey S, Rozières A, Viret C, Faure M. Autophagy. 2022 Jul 28.

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Jul 12, 2022 The broad viral inhibitors IFITMs can regulate Golgi trafficking

Li Zhong, Yuxin Song, Federico Marziali, Rustem Uzbekov, Xuan-Nhi Nguyen, Chloé Journo, Philippe Roingeard, Andrea Cimarelli

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Jul 11, 2022 Alteration of microbiota antibody-mediated immune selection contributes to dysbiosis in Inflammatory Bowel Diseases

Eva Michaud, Louis Waeckel, Rémi Gayet, Roman Goguyer-Deschaumes, Blandine Chanut, Fabienne Jospin, Katell Bathany, Magali Monnoye, Coraline Genet, Amelie Prier, Caroline Tokarski, Philippe Gérard, Xavier Roblin, Nicolas Rochereau, Stéphane Paul. Embo Molecular Medicine. https://www.embopress.org/doi/full/10.15252/emmm.202115386

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Apr 13, 2022 Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome-enriched vesicles.

Michel Record, Mehdi Attia, Kevin Carayon, Laly Pucheu, Julio Bunay, Régis Soulès, Silia Ayadi, Bruno Payré, Laure Perrin-Cocon, Florence Bourgailh, Antonin Lamazière, Vincent Lotteau, Marc Poirot, Sandrine Silvente-Poirot, Philippe de Medina. Journal of Extracellular Vesicles, Volume 11 (4), April 2022, e12211.

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Mar 10, 2022 A new mechanism for perversion of the viro-induced nuclear pore

Bertrand Boson, Chloé Mialon, Konstanze Schichl, Solène Denolly, François-Loïc Cosset. mBio https://doi.org/10.1128/mbio.02923-21

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Feb 04, 2022 Predictive factors of a viral neutralizing humoral response after a third dose of COVID-19 mRNA vaccine in kidney transplant recipients

by X.Charmetant, M.Espi (...) and O.Thaunat, American Journal of Tranplantation 2022, DOI : 10.1111/ajt.16990

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Feb 01, 2022 Infection or a third dose of mRNA vaccine elicits neutralizing antibody responses against SARS-CoV-2 in kidney transplant recipients

by X.Charmetant, M.Espi (...) and O.Thaunat, Science Translational Medicine 2022 DOI : 10.1126/scitranslmed.abl6141

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Jan 21, 2022 Domain 2 of Hepatitis C Virus Protein NS5A Activates Glucokinase and Induces Lipogenesis in Hepatocytes

The team describes glucokinase activation by the NS5A protein of Hepatitis C Virus in hepatocytes, resulting in glycolysis enhancement, leading to lipogenesis, intracellular steatosis and VLDL secretion.

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Jan 19, 2022 TNF-α response in macrophages depends on clinical Legionella pneumophila isolates genotypes.

Guillemot et al. 2022. Virulence. doi: 10.1080/21505594.2021.2022861

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Nov 12, 2021 New preprint on the pyrin inflammasome

Check out our new preprint in BioRxiv by Flora and colleagues on the discovery of novel activators of the pyrin inflammasome.

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Nov 01, 2021 A prospective observational study for justification, safety, and efficacy of a third dose of mRNA vaccine in patients receiving maintenance hemodialysis

by M.Espi, X.Charmetant (...) and O.Thaunat, Kidney International 2021, DOI : 10.1016/j.kint.2021.10.040

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Co-infection with Legionella and SARS-CoV-2, France, March 2020

C. Allam et al. Emerging Infectious Diseases Volume 27, Number 11—November 2021

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ALPK1 gene mutations drive autoinflammation with ectodermal dysplasia and progressive vision loss

ALPK1 is a kinase sensing a bacterial metabolite from the LPS biosynthesis pathway. Our favorite clinician describes a new family of patients. This rare monogenic disease associated with vision loss is still poorly known in the field of autoinflammation and this description of a new family of patients should raise awareness on the inflammatory symptoms associated with this disease.

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Deciphering Legionella effector delivery by Icm/Dot secretion system reveals a new role for c-diGMP signaling

Unreported control of Type 4 secretion by the second messenger c-di-GMP signaling is revealed

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