Understanding infectious diseases to better control them
The CIRI (Centre International de Recherche en Infectiologie) brings together the scientific and medical research communities in infectious diseases and immunity in the Lyon-St Etienne area, with the University of Lyon 1, Inserm, CNRS and ENS de Lyon as main managing bodies, and Hospices Civils de Lyon and Université Jean Monnet as secondary managing bodies, and important partnerships with VetAgroSup and Institut Pasteur. More than 400 researchers with complementary disciplinary backgrounds are grouped into 3 main departments: immunologists, bacteriologists and virologists, some of them being as well as cancerologists and epidemiologists. They work together with the main objective of understanding the biology of microbes and the immune system, and the interactions between microbes and their hosts, in order to better combat infectious diseases and other illnesses involving the immune system.
- Three departments working together
Découvrir le CIRI
- Publications
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Alexandre Legrand, Rémi Demeure, Amandine Chantharath, Carine Rey, Julie Baltenneck, Cameron L. M. Gilchrist, Joana L. Rocha, Clara Loyer, Léa Picard, Andrea Cimarelli, Martin Steinegger, Francois Rousset, Peter H. Sudmant and Lucie Etienne
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Publications of RSV Study Group Lyon
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Natural killer (NK) cells have antitumor activity that is primed by IL-15 and IL-18, components of a cytokine cocktail used in NK cell–based cancer immunotherapy. Fallone et al. found that IL-15 and IL-18 synergized to activate the complex mTORC1, which resulted in increased proliferation and function of both mouse and human NK cells. IL-15 and IL-18 stimulated mTORC1 activity through distinct pathways not previously implicated in its regulation. The combination of IL-15 and IL-18 improved the survival of mice engrafted with tumor cells, suggesting a therapeutic strategy to enhance the efficacy of NK cell–based cancer immunotherapy
- Lung virome convergence precedes hospital-acquired pneumonia in intubated critically ill patients Anani et al. Cell Rep Medicine - Team VirPath-CARVI
- News
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Félicitations à Lucie ETIENNE, Directrice de Recherche au Centre International de Recherche en Infectiologie (CNRS/ ENS de Lyon / INSERM / Université Claude Bernard Lyon 1 / Hospices Civils de Lyon / Université Jean Monnet – Saint-Etienne) pour l’obtention d’un ERC Consolidator Grant pour le projet FUNEVO !
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Publication of the I2BA team in The Journal of Experimental Medicine
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International Call for the Recruitment of an Early-Career Team Leader in Virology at CIRI.
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Two recent papers, resulting from international collaborations between Bénédicte PY, DR INSERM, NLRP3 Team, and BioAge Labs in the US, R. Coll in Ireland, M. Geyer in Germany, and R. Karki in Korea, are featured in a joint highlight in Nature Reviews Drug Discovery: www.nature.com/articles/d41
- Job offers
- The HEAL team is seeking for a PhD candidate to start a research project on the cellular and molecular aspects of “Orthonairovirus: molecular determinants of transmission”
- The VIRPATH laboratory at the International Center for Research in Infectiology (CIRI) is inviting applications from motivated, independent postdoctoral researchers to lead cutting-edge projects foc (...)
- L’équipe dirigée par Olivier Thaunat recrute un·e ingénieur·e en Immunologie dans le cadre d’un projet ANR portant sur les mécanismes d’allo-reconnaissance en transplantation
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Post-doc offer at the CERP (Center of Excellence in Respiratory Pathogens)
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PERSIST Lab - Nicolas Personnic
- A PhD under a "CIFRE convention" is opened in EIA team. It will start in September 2024.
- Agenda
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“Host adaptations to viral infections” Meeting at CNRS Station Biologique de Roscoff: Register now!
Peter Sudmant (UC Berkeley, USA), David Enard (Univ. Arizona, USA) and Lucie Etienne (CIRI, CNRS / (...)
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Réunion annuelle AC42
Réseau National Hépatites de l'ANRS | Maladies Infectieuses Emergentes
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CFATG10
10èmes Journées Scientifiques de l’Autophagie
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séminaire CIRI : Pr. Miles W CARROLL (17.12.2025)
“ EBOV : Outbreaks, molecular epidemiology, immunity, persistence and surveillance ”
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SIDACTION - Rencontre scientifique & solidaire
Pour renforcer la transversalité entre ses différents programmes et axes d’intervention et (...)
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Soutenance de thèse de Pauline Bronnec, équipe I2BA (19.12.2025 à 14h00)
"Identification des variants pathogènes du gène MEFV"
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Soutenance de thèse de Julie Plantade, équipe Horigene (17.12.2025 à 14h00)
" Antibiorésistance chez la bactérie pathogène opportuniste Acinetobacter baumannii : apports (...)
