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Aug 08, 2022 Measles Virus-Imposed Remodeling of the Autophagy Machinery Determines the Outcome of Bacterial Coinfection

Claviere M, Lavedrine A, Lamiral G, Bonnet M, Verlhac P, Petkova DS, Espert L, Duclaux-Loras R, Lucifora J, Rivoire M, Boschetti G, Nancey S, Rozières A, Viret C, Faure M. Autophagy. 2022 Jul 28.

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Jul 12, 2022 The broad viral inhibitors IFITMs can regulate Golgi trafficking

Li Zhong, Yuxin Song, Federico Marziali, Rustem Uzbekov, Xuan-Nhi Nguyen, Chloé Journo, Philippe Roingeard, Andrea Cimarelli

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Jul 11, 2022 Alteration of microbiota antibody-mediated immune selection contributes to dysbiosis in Inflammatory Bowel Diseases

Eva Michaud, Louis Waeckel, Rémi Gayet, Roman Goguyer-Deschaumes, Blandine Chanut, Fabienne Jospin, Katell Bathany, Magali Monnoye, Coraline Genet, Amelie Prier, Caroline Tokarski, Philippe Gérard, Xavier Roblin, Nicolas Rochereau, Stéphane Paul. Embo Molecular Medicine. https://www.embopress.org/doi/full/10.15252/emmm.202115386

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Mar 10, 2022 A new mechanism for perversion of the viro-induced nuclear pore

Bertrand Boson, Chloé Mialon, Konstanze Schichl, Solène Denolly, François-Loïc Cosset. mBio https://doi.org/10.1128/mbio.02923-21

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Feb 04, 2022 Predictive factors of a viral neutralizing humoral response after a third dose of COVID-19 mRNA vaccine in kidney transplant recipients

by X.Charmetant, M.Espi (...) and O.Thaunat, American Journal of Tranplantation 2022, DOI : 10.1111/ajt.16990

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Feb 01, 2022 Infection or a third dose of mRNA vaccine elicits neutralizing antibody responses against SARS-CoV-2 in kidney transplant recipients

by X.Charmetant, M.Espi (...) and O.Thaunat, Science Translational Medicine 2022 DOI : 10.1126/scitranslmed.abl6141

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Jan 19, 2022 TNF-α response in macrophages depends on clinical Legionella pneumophila isolates genotypes.

Guillemot et al. 2022. Virulence. doi: 10.1080/21505594.2021.2022861

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Nov 12, 2021 New preprint on the pyrin inflammasome

Check out our new preprint in BioRxiv by Flora and colleagues on the discovery of novel activators of the pyrin inflammasome.

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Nov 01, 2021 A prospective observational study for justification, safety, and efficacy of a third dose of mRNA vaccine in patients receiving maintenance hemodialysis

by M.Espi, X.Charmetant (...) and O.Thaunat, Kidney International 2021, DOI : 10.1016/j.kint.2021.10.040

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Co-infection with Legionella and SARS-CoV-2, France, March 2020

C. Allam et al. Emerging Infectious Diseases Volume 27, Number 11—November 2021

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ALPK1 gene mutations drive autoinflammation with ectodermal dysplasia and progressive vision loss

ALPK1 is a kinase sensing a bacterial metabolite from the LPS biosynthesis pathway. Our favorite clinician describes a new family of patients. This rare monogenic disease associated with vision loss is still poorly known in the field of autoinflammation and this description of a new family of patients should raise awareness on the inflammatory symptoms associated with this disease.

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Deciphering Legionella effector delivery by Icm/Dot secretion system reveals a new role for c-diGMP signaling

Unreported control of Type 4 secretion by the second messenger c-di-GMP signaling is revealed

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New article about staphylococcal pneumonia

Prognostic factors of severe community-acquired staphylococcal pneumonia in France

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Mar 31, 2021 A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity

During liver carcinogenesis, the first enzyme of glycolysis GCK is replaced in hepatocytes by the hexokinase HK2. We show that it critically contributes to metabolic reprogramming and inhibition of innate immunity associated to liver cancer development.

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