Group members: Frédéric LAURENT (PU-PH), Jérôme JOSSE (MCU-HDR), Céline Dupieux-Chabert (MCU-PH), Camille KOLENDA (PHU), Valour (PU-PH), Allison FAURE (engineer), Quentin COLLET (PhD student)

Our objectives are :

• Elucidate the physiopathological mechanisms associated with Staphylococcal Bone and Joint Infections (BJI), particularly those favoring the chronicization of infections and their relapses

• To develop and participate in the development (as part of multidisciplinary consortiums) of new therapeutic methods to combat staphylococcal BJIs, whether new antibiotics, bacteriophages or lysins from these bacteriophages

We are particularly interested in the internalization and survival of staphylococci within osteoblasts, the bone-forming cells. This mechanism can, depending on the strains and species studied, either lead to lysis of the host cell or allow staphylococci to persist within the osteoblast while being protected from attacks by the immune system and the effect of antibiotics.

On the fundamental side, the aim of our work is to identify the bacterial and cellular determinants influencing the fate of intraosteoblastic staphylococci.

On the applied side, we work, in collaboration with different teams of chemists, to identify and develop new solutions to combat intraosteoblastic staphylococci.

Our research group is also involved in more clinical research, notably participating in the development of new diagnostic solutions for staphylococcal BJIs.

Our sponsors :