Immunological synapse
Once they have received an antigen signal, B lymphocytes will successively create synapses with different cell types along their way to differentiate into memory or effector cells. We contend that ubiquitous cytokines such as TGFβ will have differential outcomes on B cell responses depending on the B cell cellular partner. This research topic explores the molecular and cellular signals that govern B cell behavior and function upon encounter with their successive cellular partners, in particular in the context of mucosal immune responses. It is directed by Helena Paidassi (CR CNRS)