Association of IFNAR1 and IFNAR2 with COVID-19 severity
The Lancet Microbe: Yaugel-Novoa M., Bourlet T., Longet S., Botehlo-Nevers E, Paul S. https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(23)00095-2/fulltext
Type I interferons propagate and amplify the antiviral response at the start of an infection and are crucial for effective antiviral immunity. Type I interferons bind interferon alpha/beta receptors 1 (IFNAR1) and 2 (IFNAR2), which are ubiquitous, but expressed differentially depending on the cell type.
Our study suggest that serum IFNAR1 and IFNAR2 concentrations in patients with COVID-19 can be used as predictors of disease severity and response to interferon treatment outcomes.