Actualités
What role for cellular metabolism in the control of hepatitis viruses?
Olivier Diaz, Pierre-Olivier Vidalain, Christophe Ramière, Vincent Lotteau and Laure Perrin-Cocon. Front. Immunol. 13:1033314.
A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity
During liver carcinogenesis, the first enzyme of glycolysis GCK is replaced in hepatocytes by the hexokinase HK2. We show that it critically contributes to metabolic reprogramming and inhibition of innate immunity associated to liver cancer development.