Recherche COVID dans l'équipe VIRIMI
@CIRI_VIRIMI developed a reporting cellular assay for SARS-CoV-2 infection and used it to screen a metabolism-oriented library of compounds. Identified metabolic vulnerabilities of coronaviruses can be exploited for innovative therapeutic strategies.
A Bioluminescent 3CLPro Activity Assay to Monitor SARS-CoV-2 Replication and Identify Inhibitors.
Mathieu C, Touret F, Jacquemin C, Janin YL, Nougairède A, Brailly M, Mazelier M, Décimo D, Vasseur V, Hans A, Valle-Casuso JC, de Lamballerie X, Horvat B, André P, Si-Tahar M, Lotteau V, Vidalain PO.Viruses. 2021 Sep 12;13(9):1814. doi: 10.3390/v13091814.
V Lotteau's team published in J. Trans. Med. a meta-analysis of virus-host protein-protein interactions for 13 coronaviruses including #SARS-CoV2, #MERSCoV and #SARSCoV. Analysis of the #interactome highlights potential targets for treatment. The current landscape of coronavirus-host protein–protein interactions | Journal of Translational Medicine | Full Text (inist.fr)