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Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome-enriched vesicles.

Michel Record, Mehdi Attia, Kevin Carayon, Laly Pucheu, Julio Bunay, Régis Soulès, Silia Ayadi, Bruno Payré, Laure Perrin-Cocon, Florence Bourgailh, Antonin Lamazière, Vincent Lotteau, Marc Poirot, Sandrine Silvente-Poirot, Philippe de Medina. Journal of Extracellular Vesicles, Volume 11 (4), April 2022, e12211.

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Domain 2 of Hepatitis C Virus Protein NS5A Activates Glucokinase and Induces Lipogenesis in Hepatocytes

The team describes glucokinase activation by the NS5A protein of Hepatitis C Virus in hepatocytes, resulting in glycolysis enhancement, leading to lipogenesis, intracellular steatosis and VLDL secretion.

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A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity

During liver carcinogenesis, the first enzyme of glycolysis GCK is replaced in hepatocytes by the hexokinase HK2. We show that it critically contributes to metabolic reprogramming and inhibition of innate immunity associated to liver cancer development.

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Recherche COVID dans l'équipe VIRIMI

meta-analysis of virus-host protein-protein interactions for 13 coronaviruses including #SARS-CoV2, #MERSCoV and #SARSCoV

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