Domain 2 of Hepatitis C Virus Protein NS5A Activates Glucokinase and Induces Lipogenesis in Hepatocytes
by Laure Perrin-Cocon, Cindy Kundlacz, Clémence Jacquemin, Xavier Hanoulle, Anne Aublin-Gex, Marianne Figl, Jeremy Manteca, Patrice André, Pierre-Olivier Vidalain, Vincent Lotteau and Olivier Diaz.
The team describes glucokinase activation by the NS5A protein of Hepatitis C Virus in hepatocytes, resulting in glycolysis enhancement, leading to lipogenesis, intracellular steatosis and VLDL secretion.
International Journal of Molecular Sciences by MDPI