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You are here: Home / Teams / Henry T - I2BA

Henry T - I2BA

Inflammasome, bacterial infections and autoinflammation

Team presentation

The team "Inflammasomes, bacterial infection and autoinflammation" was created in Lyon, France in 2009. The team is headed by Thomas Henry and focuses on inflammasomes, their physiological activation during innate immune responses against pathogenic bacteria and their pathological activation during human autoinflammatory diseases.

The main model used in the lab to study antibacterial innate immune responses is the zoonotic bacterium Francisella novicida. This bacterium closely related to Francisella tularensis, the agent of tularemia replicates to very high number in the cytosol of macrophages and is thus a fantastic model to study cytosolic immune responses. The team study how macrophages detect invasion in the cytosol and mount an immune response. We also study how inflammasome activation is regulated by Guanylate Binding proteins (GBPs) and eicosanoids.

Francisella is a highly virulent pathogen. The team also study Francisella virulence factors and especially the type VI secretion system (T6SS), which is critical for virulence, bacterial escape into the cytosol and activation of the cytosolic immune responses including the inflammasome.

The pathological activation of inflammasomes is mainly studied in the autoinflammatory diseases linked to mutation in the MEFV gene encoding the pyrin inflammasome sensor. The most frequent pyrin-associated autoinflammatory disease is the Familial Mediterranean Fever. From the fundamental study of pyrin inflammasome mechanism, we aim at understanding the pyrin-associated diseases and develop novel therapeutic and diagnostic strategies.

Recently, we have also developed novel lines of research on ALPK1 and the associated auto-inflammatory ROSAH syndrome.

Our team belongs to the CeRéMAIA, the national reference center for autoinflammatory diseases and amyloidosis and to FAI2, the french healthcare network for rare auto-immune and auto-inflammatory diseases.

More details @ Research Projects!

The team includes about 12 people- MD, Inserm and University/ENS researchers, Engineers, Post-doctoral fellows, PhD and Master students. We are always looking for highly motivated students to join the team and our research efforts-so please apply!

More details @ Team Members

Research projects

The team is focusing on the following research themes: 1-Inflammasomes and cytosolic innate immune responses to bacteria 2-Inflammasomes and autoinflammatory diseases

Research projects - Read More…

Publications

Selected publications (2015-2022)

Full updated list availabe @: Google Scholar

2022:

Magnotti F, Chirita D, Dalmon S, Martin A, Bronnec P, Sousa J, Helynck O, Lee W, Kastner DL, Chae JJ, McDermott M, Belot A, Popoff M, Sève P, Georgin-Lavialle S, Munier-Lehmann H, Tran TA, De Langhe E, Wouters C, Jamilloux Y@, Henry T@(@co-senior author)

Cell reports, 2022 Oct 11

 

2021:

Jamilloux Y, Mathis T, Grunewald O, Dollfuss H, Henry T, Sève P, Meunier I

Journal of Clinical Immunology, 2021 June 22

 

2020:

Magnotti F, Malsot T, Georgin-Lavialle S, Abbas F, Martin A, Belot A, Fauter M, Rabilloud M, Gerfaud-Valentin M, Sève P, Duquesne A, Hot A, Durupt S, Savey L, Giurgea I, Grateau G, Henry T@, and Jamilloux Y@ (@co-senior author)

Annals of the Rheumatic Diseases, 2020 Oct 9

 

2019:

Magnotti F, Lefeuvre L, Benezech S, Malsot T, Waeckel L, Martin A, Kerever S, Chirita D, Desjonqueres M, Duquesne A, Gerfaud-Valentin M, Laurent A, Sève P, Popoff MR, Walzer T, Belot A, Jamilloux Y@, Henry T@ (@co-senior author)

EMBO Mol Med. 2019 Oct 7

Benaoudia S, Martin A, Puig Gamez M, Gay G, Lagrange B, Cornut M, Krasnykov K, Claude JB, Bourgeois CF, Hughes S, Gillet B, Allatif O, Corbin A, Ricci R, Henry T.

EMBO Rep. 2019 Jul 29

 

2018:

Tromp AT, Van Gent M, Abrial P, Martin A, Jansen JP, De Haas CJC, Van Kessel KPM, Bardoel BW, Kruse E, Bourdonnay E, Boettcher M, McManus MT, Day CJ, Jennings MP, Lina G, Vandenesch F, Van Strijp JAG, Jan Lebbink R, Haas PA, Henry T@, Spaan AN@(@co-senior author)

Nature Microbiol. 2018 May 7

Lagrange B, Benaoudia S, Wallet P, Magnotti F, Provost A, Michal F, Martin A, Di Lorenzo F, Py FB, Molinaro A, Henry T

Nature Communications, 2018 Jan; 9 (1), 242

Jamilloux Y*, Lefeuvre L*, Magnotti F*, Martin A, Benezech S, Allatif O, Penel-Page M, Hentgen V, Sève P,  Gerfaud-Valentin M, Duquesne A, Desjonquères M, Laurent A, Rémy-Piccolo V, Cimaz R, Cantarini L, Bourdonnay E, Walzer T, Py BF, Belot A, Henry T.

Rheumatology, 2018 Jan 1;57(1):100-111.

 

2017:

Wallet P*, Benaoudia S*, Mosnier A, Lagrange B, Martin A, Lindgren H, Golovlev I, Michal F, Basso P, Djebali S, Provost A, Allatif O, Meunier E, Broz P, Yamamoto M, Py BF, Faudry E, Sjöstedt A, Henry T.

Plos Pathogens, 2017 Oct2;13(10).

 

2016:

Rigard M, Bröms JE, Mosnier A, Hologne M, Martin A, Lindgren L, Punginelli C, Lays C, Walker O, Charbit A, Telouk P, Conlan W, Terradot L@, Sjöstedt A@, Henry T@(@co-senior author)

PLOS Pathogens, 2016, Aug 24

 

2015:

Spaan AN*, Reyes-Robles T*, Badiou C, Cochet S, Boguslawski KM, Yoong P, Day CJ, de   Haas CJC, van Kessel KPM, Vandenesch F, Jennings MP, Le Van Kim C, Colin Y, van Strijp JAG, Henry T@, and Torres VJ@*Co-first, @Co-corresponding/Co-senior author

Cell Host and Microbes, 2015 Aug 26

Meunier E*, Wallet P*, Dreier RF, Costanzo S, Anton L, Rühl S, Dick MS, Dussurgey S, Kistner A, Rigard M, Degrandi D, Pfeffer K, Yamamoto M, Henry T@ and Broz P@.#Co-first, @Co-corresponding author

Nature Immunology, 2015 Mar 16

Team Members

Thomas Henry

Thomas HENRY

Directeur de Recherche

CV, ORCID, GoogleScholar

e-mail

Amandine MARTIN

Ingénieur d'étude

 

e-mail

Emilie BOURDONNAY

Maître de Conférence

 

e-mail

Yvan JAMILLOUX

MCU-PH

 

e-mail

Elena Rondeau

Post-doc/AGPR

 

e-mail

Chloé Briand

Engineer

 

e-mail

Solène Caron

PhD student

 

e-mail

Diane Soussant

Post-doc

 

e-mail

Flora MAGNOTTI

Post-doc

 

e-mail

Manon DEGABRIEL

PhD student

 

e-mail

Pauline BRONNEC

PhD student

 

e-mail

Sarah DALMON

PhD student

 

e-mail

 

Mélissa MARCOTTE

Ingénieur

e-mail

 

Clarisse DOUTRIAUX

Master 2 student

e-mail

Sandrine BOISSET

PU-PH

e-mail

 

Join Us!

We are looking for motivated students and post-doc-please apply

News

Meetings, publications and miscellaneous events!

News - Read More…