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Co-infection with Legionella and SARS-CoV-2, France, March 2020

C. Allam et al. Emerging Infectious Diseases Volume 27, Number 11—November 2021

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ALPK1 gene mutations drive autoinflammation with ectodermal dysplasia and progressive vision loss

ALPK1 is a kinase sensing a bacterial metabolite from the LPS biosynthesis pathway. Our favorite clinician describes a new family of patients. This rare monogenic disease associated with vision loss is still poorly known in the field of autoinflammation and this description of a new family of patients should raise awareness on the inflammatory symptoms associated with this disease.

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Deciphering Legionella effector delivery by Icm/Dot secretion system reveals a new role for c-diGMP signaling

Unreported control of Type 4 secretion by the second messenger c-di-GMP signaling is revealed

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New article about staphylococcal pneumonia

Prognostic factors of severe community-acquired staphylococcal pneumonia in France

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Mar 31, 2021 A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity

During liver carcinogenesis, the first enzyme of glycolysis GCK is replaced in hepatocytes by the hexokinase HK2. We show that it critically contributes to metabolic reprogramming and inhibition of innate immunity associated to liver cancer development.

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Massive clonal expansion of polycytotoxic skin and blood CD8+ T cells in patients with toxic epidermal necrolysis

Villani AP, Rozieres A, Bensaid B, Eriksson KK, Mosnier A, Albert F, Mutez V, Brassard O, Baysal T, Tardieu M, Allatif O, Fusil F, Andrieu T, Jullien D, Dubois V, Giannoli C, Gruffat H, Pallardy M, Cosset FL, Nosbaum A, Kanagawa O, Maryanski JL, Yerly D, Nicolas JF, Vocanson M

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