Soutenance de thèse : Aurélien Peyron, équipe GIMAP (13/09/2024)
| When |
Sep 13, 2024
from 02:00 PM to 05:00 PM |
|---|---|
| Where | Amphithéâtre Simone Veil, Faculté de Médecine, Saint-Etienne |
Summary: Coagulase-negative staphylococci including the endemic and multidrug-resistant S. capitis NRCS-A stand out as a major cause to late-onset sepsis in preterm neonates. Given that coagulase-negative staphylococci are frequently recovered from the feces of preterm neonates, we sought to investigate whether S. capitis could cross the intestinal mucosa and trigger sepsis. To address this question, we studied how S. capitis interact with enterocytes and microfold cells in vitro. Additionally, we developed a force-feeding in two-day-old mouse pups to assess the ability of S. capitis to translocate and induce sepsis. Finally, we developed an innovative procedure using digestive explant of a human newborn to study if S. capitis NRCS-A can invade the intestinal mucosa ex vivo.
Dr BONAZZI Matteo (DR2) IRIM Rapporteur
Dr TAZI Asmaa (MCU-PH) IC Rapporteure
Pr LAURENT Fréderic (PU-PH) CIRI Examinateur
Pr VERHOEVEN Paul (PU-PH) CIRI Directeur de thèse
Pr BUTIN Marine (PU-PH) CIRI Co-directrice de thèse
Dr TRISTAN Anne (MCU-PH) CIRI Invitée
Dr ZOUED Abdelrahim (CR) CIRI Invité