Surveillance of nosocomial influenza transmission at the Hospices Civils of Lyon : NOSO-GRIPPE

The description of nosocomial risk is a key element in order to identify the factors facilitating hospital clusters. These factors have a major impact on the management and organization of care. The analysis of nosocomial influenza surveillance, initiated in 2004 at the GHC (Central Hospital) is useful to identify the differences and similarities of infections linked to different influenza viruses.

• Main objective: To describe and document the cases of nosocomial influenza, their clinical spectrum and their determinant occurring at the Hospices Civils de Lyon.

• Secondary objective(s):

Describe and document the cases of community influenza likely to be a source of nosocomial influenza, their clinical spectrum and their determinant occurring at the Hospices Civils de Lyon.

Describe and document the cases of community influenza likely to be a source of nosocomial influenza, their clinical spectrum and their determinant occurring at the Hospices Civils of Lyon.

Describe influenza-like illness (ILI) populations by inpatient ward

To possibly question the 72-hour period in the definition of nosocomial influenza

Expected benefits: Gain a better understanding of the chains of transmission of nosocomial influenza; raise awareness among professionals about the spread of the influenza virus in hospitals; raise awareness of their role in preventing the spread of the virus in hospitals and their immediate environment; complement existing recommendations

Publications

- El Guerche-Séblain C, Amour S, Bénet T, Hénaff L, Escuret V, Schellevis F, Vanhems P. Incidence of hospital-acquired influenza in adults: A prospective surveillance study from 2004 to 2017 in a French tertiary care hospital. Am J Infect Control. 2020 Dec 13:S0196-6553(20)31040-3.

- Munier-Marion E, Bénet T, Vanhems P. Definition of healthcare-associated influenza: A review and results from an international survey. Influenza Other Respir Viruses. 2017 Sep;11(5):367-371.

- Munier-Marion E, Bénet T, Dananché C, Soing-Altach S, Maugat S, Vaux S, Vanhems P. Outbreaks of healthcare-associated influenza-like illness in France: impact of electronic notification. Am J Infect Control. 2017. 45(11):1249-1253.

- Vanhems P, Bénet T, Munier-Marion E. Nosocomial influenza: encouraging insights and future challenges. Curr Opin Infect Dis. 2016 Aug;29(4):366-72.

- Vanhems P, Baghdadi Y, Roche S, Bénet T, Regis C, Lina B, Robert O, Voirin N, Ecochard R, Amour S. Influenza vaccine effectiveness among healthcare workers in comparison to hospitalized patients a 2004-2009 case test, negative control, prospective study. Hum Vaccin Immunother. 2016;12(2):485-90.

- Payet C, Voirin N, Ecochard R, Vanhems P. Influence of observable and unobservable exposure on the patient's risk of acquiring influenza-like illness at hospital. Epidemiol. Infect. 2016, 144, 2025–2030.

- Oussaid N, Voirin N, Régis C, Khanafer N, Martin-Gaujard G, Vincent A, Comte B, Bénet T, Vanhems P. Contacts between health care workers and patients in a short-stay geriatric unit during the peak of a seasonal influenza epidemic compared with a nonepidemic period. Am J Infect Control. 2016 Aug 1;44(8):905-9. 

- Munier-Marion E, Bénet T, Régis C, Lina B, Morfin F, Vanhems P. Hospitalisation in double-occupancy rooms and the risk of hospital-acquired influenza: a prospective cohort study. Clin Microbiol Infect. 2016 May;22(5):461.e7-9.

- Voirin N, Payet C, Barrat A, Cattuto C, Khanafer N, Régis C, Kim BA, Comte B, Casalegno JS, Lina B, Vanhems P. Combining high-resolution contact data with virological data to investigate influenza transmission in a tertiary care hospital. Infect Control Hosp Epidemiol. 2015 Mar;36(3):254-60.

- Vanhems P, Voirin N, Bénet T, Roche S, Escuret V, Régis C, Giard M, Lina B, Comte B, Coppéré B, Ecochard R. Detection of hospital outbreaks of influenza-like illness based on excess of incidence rates compared to the community. Am J Infect Control. 2014 Dec;42(12):1325-7. 

- Régis C, Voirin N, Escuret V, Kim BA, Robert O, Lina B, Comte B, Vanhems P. Five years of hospital based surveillance of influenza-like illness and influenza in a short-stay geriatric unit. BMC Research Notes 2014, 7:99.

- Eibach D, Casalegno JS, Bouscambert M, Bénet T, Regis C, Comte B, Kim BA, Vanhems P, Lina B. Routes of transmission during a nosocomial influenza A(H3N2) outbreak among geriatric patients and healthcare workers. J Hosp Infect. 2014 Mar;86(3):188-93.

- P Vanhems, A Barrat, C Cattuto, JF Pinton, N Khanafer, C Régis, BA Kim, B Comte, N Voirin. Estimating potential infection transmission routes in hospital wards using wearable proximity sensors. PLoS One 2013; 8(9):e73970.

- Bénet T, Cassier P, Voirin N, Morélon-Daum S, Floret D, Gillet Y, Gueugniaud PY, Vanhems P. Correlation between emergency room visits for influenza-like illness during the influenza A (H1/N1) pandemic in children and adults. Influenza Other Respir Viruses 2013 May;7(3):364-6.

- Payet C, Voirin N, Vanhems P, Ecochard R. A statistical model to assess the risk of communicable diseases associated with multiple exposures in healthcare settings. BMC Med Res Methodol. 2013 Feb 20;13:26.

- Bénet T, Régis C, Voirin N, Robert O, Lina B, Cronenberger S, Comte B, Coppéré B, Vanhems P. Influenza vaccination of healthcare workers in acute-care hospitals, a case-control study of its effect on hospital-acquired influenza among patients. BMC Infectious Diseases 2012,12:30.

- Amour S, Voirin N, Regis C, Bouscambert-Duchamp M, Comte B, Coppere B, Pires-Cronenberger S, Lina B, Vanhems P. Influenza vaccine effectiveness among adult patients in a University of Lyon hospital (2004–2009). Vaccine 2012; 30:821-4.

- Voirin N, Roche S, Vanhems P, Giard M, David-Tchouda S, Barret B, Ecochard R. A multiplicative hazard regression model to assess the risk of disease transmission at hospital during community epidemics. BMC Med Res Methodol. 2011 Apr 20;11:53.

- Vanhems P, Voirin N, Roche S, Escuret V, Regis C, Gorain C, Pires-Cronenberger S, Giard M, Lina B, Najioullah F, Barret B, Pollissard L, David S, Crozet MN, Comte B, Hirschel B, Ecochard R. Risk of influenza-like illness in an acute health care setting during community influenza epidemics in 2004–2005, 2005–2006, and 2006–2007: a prospective study. Archives of Internal Medicine 2011;171: 151–157.

- Voirin N, Barret B, Metzger MH, Vanhems P. Hospital-acquired influenza: a synthesis using the Outbreak Reports and Intervention Studies of Nosocomial Infection (ORION) statement. J Hosp Infect. 2009 Jan;71(1):1-14.

- Régis C, Gorain C, Pires-Cronenberger S, Crozet MN, Moalla M, Najioullah F, Escuret V, Morfin F, Pollissard L, Barret B, Lina B, Voirin N, Vanhems P. La grippe nosocomiale chez les adultes à HEH hivers 2004-2005, 2005-2006 et 2006-2007. BEH 34 / 9 septembre 2008.