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Neutralizing and protective antibody targets the prefusion conformation of Measles virus F and arrests it in the refolding intermediate

Zyla DS, Marca RD, Niemeyer G, Zipursky G, Stearns K, Leedale C, Callaway H, Sobolik E, Hariharan C, Parekh D, Avalos RD, Horvat B, Mathieu C, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Saphire EO. Science, 384, 1423, 28 June 2024, doi: 10.1126/science.adm8693

A vaccine targeting antigen-presenting cells through CD40 induces protective immunity against Nipah disease

Pastor Y., Reynard O., Iampietro M., Surenaud M., Picard F., el Jah-rani N., Lefebvre C., Hammoudi A., Dupaty L., Brisebard E., Reynard S., Moureaux E., Moroso M., Durand S., Gonzalez C., Amurri L., Gallouet A-S., Marlin R., Baize S., Chevillard E., Raoul H., Hocini H., Centlivre M., Thiébaut R., Horvat B., Godot V., Levy Y., and Cardinaud S. Cell Rep. Med., 5:101467, March 19, 2024


SARS-CoV-2 awakens ancient retroviral genes and expression of HERV-W envelope in COVID-19 patients

Charvet B., Brunel J., Pierquin J., Iampietro M., Decimo D., Queruel N., Lucas A., del Mar Encabo-Berzosa M., Arenaz I., Perez Marmolejo T., Gonzalez Gonzalez A.I., Castorena Maldonado A., Mathieu C., Küry P., Flores-Rivera J., Torres-Ruiz F., Avila Rios S., Montes de Oca G.S., Schoorlemmer J., Perron H, Horvat B. iScience 26(5):106604, 2023 doi:10.1016/j.isci.2023.106604

Mouse models of Henipavirus infection

Iampietro M., Barron S., Duthey A., Horvat B. In: Freiberg, A.N., Rockx, B. (eds) Nipah Virus: Methods and Protocols, part of Springer Nature, Humana, New York, Chapter 12 in Methods Mol Bio, 2682:137-147, 2023, doi: 10.1007/978-1-0716-3283-3_10

Interplay between RNA viruses and cGAS/STING axis in innate immunity

Amurri L., Horvat B., Iampietro M. Frontiers Cell Infection Microbiol. 2023, doi: 10.3389/fcimb.2023.1172739


Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection

Reynard O., Gonzalez C., Dumont C., Iampietro M., Ferren M., Le Guellec S., Lajoie L, Mathieu C., Carpentier G., Roseau G., Bovier T.F., Zhu Y., Le Pennec D., Montharu J., Addetia A., Greninger A.L., Alabi C, Moscona A, Vecellio L, Porotto M., Horvat B., Nature Comm., 13:6439, 2022,

Specific intracellular signature of SARS-CoV-2 infection using confocal Raman microscopy

Salehi H., Ramoji A., Mougari S., Merida P., Neyret A., Popp J., Horvat B*., Muriaux D.*, Cuisinier F*. (*co- corresponding authors), Commun. Chem. 5:85, 2022,

Hamster Organotypic Kidney Culture model of early-stage SARS-CoV-2 infection highlights a two-step renal susceptibility

Shyfrin S.R., Ferren M., Perrin-Cocon L., Espi M., Charmetant X., Brailly M., Decimo D., Iampietro M., Canus L., Horvat B., Lotteau V., Vidalain P.O., Thaunat O. and Mathieu C., J. Tissue Engineering, 13: 1–15, 2022,


Reprogrammed Pteropus bat stem cells as a model to study host-pathogen interaction during Henipavirus infection

Aurine N., Baquerre C., Gaudino M., Jean C., DumontC., Rival-Gervier S., Kress C., Horvat B*., Pain B* (*co-corresponding authors). Microorganisms, 9: 2567, 2021, doi : 10.3390/microorganisms9122567

Nipah virus W protein harnesses nuclear 14-3-3 to inhibit NF-κB-induced proinflammatory response

Enchéry F., Dumont C., Iampietro M., Pelissier, Noémie R. Aurine N., Bloyet L.M., Carbonnelle C., Mathieu C., Journo C., Gerlier D. and Horvat B. Communications Biol. 4 :1292, 2021, DOI: 10.1038/s42003-021-02797-5

Highly potent host-specific small molecule inhibitor of Paramyxovirus and Pneumovirus replication with high resistance barrier

Shrestha N., Gall F., Mathieu C., Hierweger M., Brügger M., AlvesM., Vesin J., Banfi D., Kalbermatter D., Horvat B., Chambon M., Turcatti G., FotiadisD., RiedlR., and Plattet P. mBio, 12(6): e02621-21, 2021, doi: 10.1128/mBio.02621-21

Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection

Ferren M, Favede V, Decimo D, Iampietro M, Lieberman NAP, Weickert JL, Pelissier R, Mazelier M, Terrier O, Moscona A, Porotto M, Greninger AL, Messaddeq N, Horvat B, Mathieu C. Nature Comm Oct 4;12(1):5809, doi: 10.1038/s41467-021-26096-z

A Bioluminescent 3CLPro Activity Assay to Monitor SARS-CoV-2 Replication and Identify Inhibitors

Mathieu C., Touret F., Jacquemin C., Yves J., Nougairède A., Brailly M., Mazelier M., Décimo D., Vasseur V., Hans A., Valle-Casuso J.C., de Lamballerie X., Horvat B., André P., Si-Tahar M., Lotteau V., Vidalain P.O. Viruses, 13:1814, 2021, doi: 10.3390/v13091814

Identification of a Region in the Common Amino-terminal Domain of Hendra Virus P, V, and W Proteins Responsible for Phase Transition and Amyloid Formation

Salladini E., Gondelaud F., Nilsson J.F., Pesce G., Bignon B., Murrali M.G., Fabre R., Pierattelli R., Kajava A., Horvat B., Gerlier D., Mathieu C., Longhi S. Biomolecules, 2021 Sep 7;11(9):1324. doi: 10.3390/biom11091324

Rapid and flexible platform to assess anti SARS-CoV-2 antibody neutralization and spike protein-specific antivirals

Stelitano D., Weisberg S., Goldklang M., Zhu Y., Bovier F., Cennamo M., Kalantarov., Décimo D., Franci G., Greco G., Portella G., Galdiero M., Mathieu C., Horvat B., Trakht, I. Moscona A., Whitt M., and Porotto M. mSphere, 6 (4): e00571-21, 2021, DOI: 10.1128/mSphere.00571-21

Activation of cGAS/STING pathway upon paramyxovirus infection

Iampietro M., Dumont C., Mathieu C., Spanier J., Robert J., Charpenay A., Dupichaud S., Dhondt K., Aurine N., Pelissier R., Ferren M., Mély S., Gerlier D., Kalinke U and Horvat B.:  iScience, May 7;24(6):102519, 2021, doi:

Single-chain variable fragment antibody constructs neutralize measles virus infection in vitro and in vivo

Mathieu C., Ferren M., Harder O., Bovier F., Marcink T., Predella C., Angius F., Drew-Bear J., Dorrello N., Greninger A., Moscona A., Niewiesk S., Horvat B. and Porotto M. Cell & Moll. Immunol. Jul;18(7):1835-1837, 2021, doi: 10.1038/s41423-021-00691-y

Molecular features of the measles virus viral fusion complex that favor infection and spread in the brain

Mathieu C., Bovier F., Ferren M., Lieberman N., Predella C., Lalande A., Peddu V., Lin M., Addetia A., Patel A., Outlaw V., Barbara C., Dorrello N., Briese T., Hardie D., Horvat B., Moscona A., Greninger A., and Porotto M. mBio, 13(3): e00799-21, 2021, doi: 10.1128/mBio.00799-21

Evidence of the pathogenic HERV-W envelope expression in T lymphocytes in association with the respiratory outcome of COVID-19 patients

Balestrieri E., Minutolo A., Petrone V., Fanelli M., Iannetta M., Malagnino V., Zordan M., Vitale P., Charvet B., Horvat B., Sergio Bernardini, MD 1, Enrico Garaci, MD 6, di Francesco P., Sinibaldi Vallebona P., Sarmati L., Grelli S., Andreoni M., Perron H. Matteucci C. Lancet EBioMedicine Apr; 66:103341, 2021,

SARS-CoV-2 induces transcription of human endogenous retrovirus RNA followed by type W envelope protein expression in human lymphoid cells

Charvet B., Mazelier M., Brunel J., Pierquin J., Mougari S., Iampietro M., DecimoD., Queruel N., Mathieu C., Horvat B., Perron H. Research Square

Human Endogenous Retrovirus Type W Envelope from Multiple Sclerosis Demyelinating Lesions Shows Unique Solubility and Antigenic Characteristics

Charvet B., Pierquin P., Brunel J., Gorter R., Quétard C., Horvat B., Amor S., Portoukalian J, Perron H. Virologica Sinica, 2021 Mar 26. doi: 10.1007/s12250-021-00372-0

Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum.

Weisberg S., Connors T., Zhu Y., Baldwin M., Lin W., Wontakal S., Szabo P.A., Wells S.B., Dogra P., Gray J., Idzikowski E., Davis-Portado J., Matsumoto R., Meimei Li Poon M., Chait M., Mathieu C., Horvat B., Decimo D., Mace E., Milner J., Moscona A., Hod E., Porotto M. and Farber D.L.: Nature Immunol. Jan;22(1):25-31, 2021/

Organotypic modeling of SARS-CoV-2 lung and brainstem infection.

Ferren M, Favede V, Decimo D, Iampietro M, Lieberman NAP, Weickert JL, Pelissier R, Mazelier M, Terrier O, Moscona A, Porotto M, Greninger AL, Messaddeq N, Horvat B, Mathieu C. doi:10.21203/ Research Square.

Interféron de type 1 et sélectivité de l’infection des cellules du système nerveux central par le virus de la rougeole Ferren F., Horvat B., Gerlier D. et Mathieu C m/s n° 1, vol. 37 : 22-25, 2021,



Activation of cGAS/STING pathway upon paramyxovirus infection

Iampietro M., Dumont C., Mathieu C., Spanier J., Robert J., Charpenay A., Dupichaud S., Dhondt K., Aurine N., Pelissier R., Ferren M., Mély S., Gerlier D., Kalinke U and Horvat B. bioRxiv,

Reprogrammed Pteropus bat stem cells present distinct immune signature and are highly permissive for Henipaviruses.

Aurine N., Baquerre C., Gaudino M., Jean C., Dumont C., Rival-Gervier S., Kress C., Horvat B*., Pain B* (*co-corresponding authors): bioRxiv :

Sequencing the genome of Indian Flying Fox, natural reservoir of Nipah virus, using hybrid assembly and conservative secondary scaffolding.

Fouret J., Brunet F.G., Binet M., Aurine A., Enchéry F., Croze S., Guinier M., Goumaidi A., Preininger D., Volff J.N., Bailly-Bechet M., Lachuer J., Horvat B*, Legras-Lachuer C.* (*co-corresponding authors) Frontiers Micorbiol., 11:1807, 2020 doi : 10.3389/fmicb.2020.01807

Quercetin blocks Ebola Virus infection by counteracting the VP24 Interferon inhibitory function.

Fanunza E., Iampietro M., Distinto S., Corona A., Quartu M., Maccioni E., Horvat B., Tramontano E. : Antimicrobial Agents and Chemotherapy (AAC), 64(7): e00530-20, 2020, doi: 10.1128/AAC.00530-20

Production of the Spike protein, allowing assembly of virus-like particles

Boson B, Legros V, Zhou B, Siret E, Mathieu C, Cosset FL, Lavillette D, Denolly S.

J Biol Chem. 2020 Dec 3:100111. doi: 10.1074/jbc.RA120.016175

MAVS and MyD88 - mediated signaling restrains lethal Nipah virus infection in mice

Iampietro M., Aurine N., Dhondt K.P., Dumont C., Pelissier R., Spanier J., Vallve A., Raoul H., Kalinke U., Horvat B.  Infect. Diseas 221(S4): S401–S406, 2020 doi: 10.1093/infdis/jiz602

The C Protein Is Recruited to Measles Virus Ribonucleocapsids by the Phosphoprotein.

Pfaller CK, Bloyet LM, Donohue RC, Huff AL, Bartemes WP, Yousaf I, Urzua E, Clavière M, Zachary M, de Masson d'Autume V, Carson S, Schieferecke AJ, Meyer AJ, Gerlier D, Cattaneo R. J Virol. 2020 Jan 31;94(4). pii: e01733-19. doi: 10.1128/JVI.01733-19.


Control of Nipah Virus Infection in Mice by the Host Adaptors Mitochondrial Antiviral Signaling Protein (MAVS) and Myeloid Differentiation Primary Response 88 (MyD88). ampietro M, Aurine N, Dhondt KP, Dumont C, Pelissier R, Spanier J, Vallve A, Raoul H, Kalinke U, Horvat B.

J. Infect Dis. Dec 19. pii: jiz602, 2019 doi: 10.1093/infdis/jiz602

Recent advances in the understanding of Nipah virus immunopathogenesis and anti-viral approaches. Pelissier R, Iampietro M, Horvat B.

F1000Res. Oct 16;8. pii: 1763, 2019 doi: 10.12688/f1000research.19975.1.

Regulation of measles virus gene expression by P protein coiled-coil properties.  Bloyet, L.M. Schramm, A., Lazert, C., Raynal B., Hologn M., Walker O., Longhi S., and Gerlier D.

Sci. Adv. 5, eaaw3702 (2019), doi: 10.1126/sciadv.aaw3702.

Inhibiting Human Parainfluenza Virus Infection by Preactivating the Cell Entry Mechanism.  Bottom-Tanzer SF, Rybkina K, Bell JN, Alabi CA, Mathieu C, Lu M, Biswas S, Vasquez M, Porotto M, Melero JA, Más V, Moscona A.

mBio. 2019 Feb 19;10(1). pii: e02900-18. doi: 10.1128/mBio.02900-18

Measles Encephalitis: Towards New Therapeutics. Ferren M, Horvat B., Mathieu C.

Viruses, 11(11), 2019 doi: 10.3390/v11111017

Type I Interferon receptor signaling drives selective permissiveness of astrocytes and microglia to measles virus during brain infection. Welsch J., Charvet B., Dussurgey S., Allatif O., Aurine N., Horvat B., Gerlier D., and Mathieu C.

J. Virol. 2019, 2019 Apr 24. pii: JVI.00618-19. doi: 10.1128/JVI.00618-19

Measles virus bearing MIBE-derived fusion protein is pathogenic after infection via the respiratory route. Mathieu C., Ferren M., Jurgens E., Dumont C., Rybkina K., Harder O., Stelitano D., Ladeddu S, Sanna G., Schwartz D., Biswas S., Hardie D., Hashiguchi T., Moscona A., Horvat B., Niewiesk S. and Porotto M.

J. Virol. 93(8) : 01862-18, 2019 doi: 10.1128/JVI.01862-1

Analysis of a subacute sclerosing panencephalitis (SSPE) Genotype B3 virus from the 2009/10 South African measles epidemic shows hyperfusogenic F proteins contribute to measles virus infection in the brain. Angius F., Smuts H., Rybkina K., Stelitano D., Eley B., Wilmshurst J., Ferren M., Lalande A., Mathieu C., Moscona A., Horvat B., Hashiguchi T., Porotto M., and Hardie D.

J. Virol. 2019 Feb 5;93(4). pii: e01700-18. doi: 10.1128/JVI.01700-18


Fusion inhibitory lipopeptides engineered for prophylaxis of Nipah virus in primates.  Mathieu C., Porotto M., Figueira T., Horvat B, Moscona A.

J. Infect. Dises. 218(2): 218-227, 2018, doi: 10.1093/infdis/jiy152.

Induction of proinflammatory multiple sclerosis-associated retrovirus envelope protein by human herpesvirus-6A and CD46 receptor engagement. Charvet B., Reynaud J.M., Gourru-Lesimple G., Perron H., Marche P.N. and Horvat B.

Front. Immunol., 9:2803, 1-14, 2018. doi: 10.3389/fimmu.2018.02803

HHV-6 Fondation newsletter


An ultraweak interaction in the intrinsically disordered replication machinery is essential for measles virus function. Milles S, Jensen MR, Lazert C, Guseva S, Ivashchenko S, Communie G, Maurin D, Gerlier D, Ruigrok RWH, Blackledge M.

Sci Adv. 2018, Aug 22;4(8),:eaat7778. doi: 10.1126/sciadv.aat7778. eCollection 2018 Aug


Organotypic brain cultures: a framework for studying CNS infection by neurotropic viruses and screening antiviral drugs. Welsch C.J., Lionnet C., TerzianC., Horvat B., Gerlier D., and Mathieu C.

Bio-protocol 7(22): e2605, 2017, doi: 10.21769/BioProtoc.2605.

Broad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides. Mathieu C., Augusto M.T., Niewiesk S., Horvat B., Palermo L.M., Sanna G., Huey D., Castanho M.A.R.B., Porotto M., Santos N.C., Moscona A.

Scient. Rep., 7:436102017. doi:10.1038/srep43610

Measles virus infection of human keratinocytes: Possible link between measles and atopic. Gourru-Lesimple G., Mathieu C., Thevenet T., Guillaume-Vasselin V., Jégou J.F., Boer C.G., TomczakK., Bloyet L.M., Giraud C., Grande S., Goujon C., Cornu C. and Horvat B.

Dermatol. Science, Feb 10, 2017, doi: 10.1016/j.jdermsci.2017.01.015

INSERM actualité


In vivo efficacy of measles virus fusion protein-derived peptides is modulated by properties of self-assembly and membrane residence. Figueira T.N., Palermo L.M., Veiga A.S., Huey D., Alabi C.A., Santos N.C., Welsch J.C., Mathieu C., Horvat B., Niewiesk S., Moscona A., Castanho M.A.R.B. and Porotto M.

J. Virol. 91(1): e0554-16 2017. PMID: 27733647

Understanding the interaction between henipaviruses and their natural host, fruit bats: paving the way towards control of highly lethal infection in humans. Enchery F., Horvat B

Internat. Rev. Immunol. Jan 6:1-14. 2017, doi: 10.1080/08830185.2016.1255883


Measles virus hemagglutinin triggers intracellular signaling in CD150-expressing dendritic cells and inhibits immune response.
Romanets-Korbut O., Kovalevska L., Seya T., Sidorenko S.P.,  Horvat B.
Cell & Mol Immunol. 13:828-838, 2016. doi: 10.1038/cmi.2015.55 Modulation of Re-initiation of Measles Virus Transcription at Intergenic Regions by PXD to NTAIL Binding Strength.
Bloyet LM, Brunel J, Dosnon M, Hamon V, Erales J, Gruet A, Lazert C, Bignon C, Roche P, Longhi S, Gerlier D.
PLoS Pathog. 2016 Dec 9;12(12):e1006058. doi: 10.1371/journal.ppat.1006058. Protection from Hendra virus infection with Canarypox recombinant vaccine.
Guillaume-Vasselin V., Lemaitre L., Dhondt K.P., Tedeschi L, Poulard A., Charreyre C. and Horvat B.
Nature pj Vaccines, 1: 16003, 2016, doi:10.1038/npjvaccines.2016.3 Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
Uchikawa E, Lethier M, Malet H, Brunel J, Gerlier D, Cusack S.
Mol Cell 62, 586-602, 2016, doi: 10.1016/j.molcel.2016.04.021. HSP90 Chaperoning in Addition to Phosphoprotein Required for Folding but Not for Supporting Enzymatic Activities of Measles and Nipah Virus L Polymerases.
Bloyet LM, Welsch J, Enchery F, Mathieu C, de Breyne S, Horvat B, Grigorov B, Gerlier D.
J Virol. 90(15):6642-56, 2016. doi: 10.1128/JVI.00602-16

Intradermal immunisation using the TLR3-ligand Poly (I:C) as adjuvant induces mucosal antibody responses and protects against genital HSV-2 infection. Bardel E., Doucet-Ladeveze R., Mathieu C., Harandi A.M., Dubois D. and Kaiserlian D.

Nature pj Vaccines, 1: 16010, 2016. doi:10.1038/npjvaccines.2016.10

Latency Entry of Herpes Simplex Virus 1 Is Determined by the Interaction of Its Genome with the Nuclear Environment. Maroui MA, Callé A, Cohen C, Streichenberger N, Texier P, Takissian J, Rousseau A, Poccardi N, Welsch J, Corpet A, Schaeffer L, Labetoulle M, Lomonte P.

PLoS Pathog. 2016 Sep 12;12(9):e1005834

Fuzzy regions in an intrinsically disordered protein impair protein-protein interactions.
Gruet A, Dosnon M, Blocquel D, Brunel J, Gerlier D, Das RK, Bonetti D, Gianni S, Fuxreiter M, Longhi S, Bignon C.
FEBS J.  283(4):576-94, 2016. doi: 10.1111/febs.13631


Heparan Sulfate-dependent enhancement of Henipavirus infection.
Mathieu C., Dhondt K.P., Châlons M., Mély S., Raoul H., Negre D., Cosset F.L., Gerlier D., Vivès R.R., and Horvat B.
mBio, 6(2): e02427-14, 2015. doi: 10.1128/mBio.02427-14 Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5.
Louber J, Brunel J, Uchikawa E, Cusack S, Gerlier D.
BMC Biol. 28;13:54, 2015. doi: 10.1186/s12915-015-0166-9 Expression of CD150 in tumors of the central nervous system: identification of a novel isoform.
Romanets-Korbut O., Najakshin A.M., Yurchenko M., Malysheva T.A., Kovalevska L., Shlapatska L.M., Zozulya Y.A., Taranin A.V.,  Horvat B., Sidorenko S.P.
Plos One, 10(2):e0118302, 2015. doi: 10.1371/journal.pone.0118302 Prevention of Measles infection by intranasal delivery of fusion inhibitory peptides.
Mathieu C., Huey D., Jurgens E., Welsch J.C., DeVito I., Talekar A., Horvat B., Niewiesk S., Moscona A., and Porotto M.
J. Virol. 89(2):1143-1155, 2015. doi: 10.1128/JVI.02417-14 Suppression of Smad-1 mRNA expression level by Smad-2 likely control dichotomy of NF-κB and Smads mediated activation.
Slade N., Zorić A., Horvat B., Vukšić M., Kostović I., Poljak L.
Immunobiology. 220(1): 48-53, 2015. doi: 10.1016/j.imbio.2014.09.003 Measles fusion machinery is dysregulated in neuropathogenic variants,
JurgensE.M., Mathieu C., Palermo L.M., Hardie D., Horvat B., Moscona A.,and Porotto M.
mBio, 2015 Feb 10;6(1). pii: e02528-14. doi: 10.1128/mBio.02528-14 Henipavirus pathogenesis and anti-viral approaches.
Mathieu C. & Horvat B.
Expert Rev Anti Infect Ther 29:1-12, doi: 10.1586/14787210.2015.1001838., 2015 Measles Virus: Identification in the M Protein Primary Sequence of a Potential Molecular Marker for Subacute Sclerosing Panencephalitis.
Kweder, H., Ainouze, M., Brunel, J., Gerlier, D., Manet, E., and Buckland, R. (2015).
Adv Virol 2015, 2015:769837. doi: 10.1155/2015/769837


RIG-I self-oligomerization is either dispensable or very transient for signal transduction.
Louber, J., Kowalinski, E., Bloyet, L-M., Brunel, J., Cusack, S., Gerlier, D.
PLoS One, 2014, 26;9(9):e108770. doi: 10.1371/journal.pone.0108770. Sequence of events in measles virus replication: role of phosphoprotein-nucleocapsid interactions.
Brunel, J. Chopy, D.,Dosnon, M. Bloyet, L-M. Devaux, P., Urzua, E., Cattaneo, R., Longhi, S. Gerlier, D.
J. Virol. 2014,  88(18):10851-63. doi: 10.1128/JVI.00664-14. Human Herpesvirus 6A infection in CD46 transgenic mice: viral prevalence in the brain and increased production of proinflammatory cytokines via TLR9.
Reynaud J., Jégou J.F., Welsch J., Horvat. B.
J. Virol. 2014, 88 (10): 5421-5436, 2014. doi: 10.1128/JVI.03763-13. Recent developments in animal models for human herpesvirus 6A and 6B.
Horvat B., Berges B.K., Lusso P.
Curr. Opin. Virol. 2014, 9 :97-103, 2014. doi: 10.1016/j.coviro.2014.09.012


Fatal measles virus infection prevented by brain-penetrant fusion inhibitors.
Welsch JC, Talekar A, Mathieu C, Pessi A, Moscona A, Horvat B, Porotto M.
J Virol. 2013 Dec;87(24):13785-94. doi: 10.1128/JVI.02436-13. Animal models for human herpesvirus 6 infection.
Reynaud JM, Horvat B.
Front Microbiol. 2013 Jul 4;4:174. doi: 10.3389/fmicb.2013.00174. Dissecting Partner Recognition by an Intrinsically Disordered Protein Using Descriptive Random Mutagenesis.
Gruet A, Dosnon M, Vassena A, Lombard V, Gerlier D, Bignon C, Longhi S.
J Mol Biol. 2013 Jun 25. doi:pii: S0022-2836(13)00405-1. 10.1016/j.jmb.2013.06.025. The V protein of Tioman virus is incapable of blocking type I interferon signaling in human cells.
Caignard G, Lucas-Hourani M, Dhondt KP, Labernardière JL, Petit T, Jacob Y, Horvat B, Tangy F, Vidalain PO.
PLoS One. 2013;8(1):e53881. doi: 10.1371/journal.pone.0053881. Protection against henipavirus infection by use of recombinant adeno-associated virus-vector vaccines.
Ploquin A, Szécsi J, Mathieu C, Guillaume V, Barateau V, Ong KC, Wong KT, Cosset FL, Horvat B, Salvetti A.
J Infect Dis. 2013 Feb 1;207(3):469-78. doi: 10.1093/infdis/jis699. Type I interferon signaling protects mice from lethal henipavirus infection.
Dhondt KP, Mathieu C, Chalons M, Reynaud JM, Vallve A, Raoul H, Horvat B.
J Infect Dis. 2013 Jan 1;207(1):142-51. doi: 10.1093/infdis/jis653 Mechanism for active membrane fusion triggering by morbillivirus attachment protein.
Ader N, Brindley M, Avila M, Örvell C, Horvat B, Hiltensperger G, Schneider-Schaulies J, Vandevelde M, Zurbriggen A, Plemper RK, Plattet P.
J Virol. 2013 Jan;87(1):314-26. doi: 10.1128/JVI.01826-12.


Nonstructural Nipah virus C protein regulates both the early host proinflammatory response and viral virulence.
Mathieu C, Guillaume V, Volchkova VA, Pohl C, Jacquot F, Looi RY, Wong KT, Legras-Lachuer C, Volchkov VE, Lachuer J, Horvat B.
J Virol. 2012 Oct;86(19):10766-75. doi: 10.1128/JVI.01203-12. A general strategy to endow natural fusion-protein-derived peptides with potent antiviral activity.
Pessi A, Langella A, Capitò E, Ghezzi S, Vicenzi E, Poli G, Ketas T, Mathieu C, Cortese R, Horvat B, Moscona A, Porotto M.
PLoS One. 2012;7(5):e36833. doi: 10.1371/journal.pone.0036833. Rapid screening for entry inhibitors of highly pathogenic viruses under low-level biocontainment.
Talekar A, Pessi A, Glickman F, Sengupta U, Briese T, Whitt MA, Mathieu C, Horvat B, Moscona A, Porotto M.
PLoS One. 2012;7(3):e30538. doi: 10.1371/journal.pone.0030538. Lethal Nipah virus infection induces rapid overexpression of CXCL10.
Mathieu C, Guillaume V, Sabine A, Ong KC, Wong KT, Legras-Lachuer C, Horvat B.
PLoS One. 2012;7(2):e32157. doi: 10.1371/journal.pone.0032157. [RIG-I: a viral RNA detector molecular switch].
Kowalinski E, Louber J, Gerlier D, Cusack S.
Med Sci (Paris). 2012 Feb;28(2):136-8. doi: 10.1051/medsci/2012282006. Plasticity in structural and functional interactions between the phosphoprotein and nucleoprotein of measles virus.
Shu Y, Habchi J, Costanzo S, Padilla A, Brunel J, Gerlier D, Oglesbee M, Longhi S.
J Biol Chem. 2012 Apr 6;287(15):11951-67. doi: 10.1074/jbc.M111.333088.


Emerging zoonotic viruses: new lessons on receptor and entry mechanisms.
Gerlier D.
Curr Opin Virol. 2011 Jul;1(1):27-34. doi: 10.1016/j.coviro.2011.05.014. Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA.
Kowalinski E, Lunardi T, McCarthy AA, Louber J, Brunel J, Grigorov B, Gerlier D, Cusack S.
Cell. 2011 Oct 14;147(2):423-35. doi: 10.1016/j.cell.2011.09.039. Virus-driven conditional expression of an interferon antagonist as a tool to circumvent host restriction.
Gerlier D.
Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17239-40. doi: 10.1073/pnas.1114431108. Rapid titration of measles and other viruses: optimization with determination of replication cycle length.
Grigorov B, Rabilloud J, Lawrence P, Gerlier D.
PLoS One. 2011;6(9):e24135. doi: 10.1371/journal.pone.0024135. Interplay between innate immunity and negative-strand RNA viruses: towards a rational model.
Gerlier D, Lyles DS.
Microbiol Mol Biol Rev. 2011 Sep;75(3):468-90, second page of table of contents. doi: 10.1128/MMBR.00007-11. Molecular characterization of measles virus strains causing subacute sclerosing panencephalitis in France in 1977 and 2007.
Moulin E, Beal V, Jeantet D, Horvat B, Wild TF, Waku-Kouomou D.
J Med Virol. 2011 Sep;83(9):1614-23. doi: 10.1002/jmv.22152. Nipah virus uses leukocytes for efficient dissemination within a host.
Mathieu C, Pohl C, Szecsi J, Trajkovic-Bodennec S, Devergnas S, Raoul H, Cosset FL, Gerlier D, Wild TF, Horvat B.
J Virol. 2011 Aug;85(15):7863-71. doi: 10.1128/JVI.00549-11.


Cellular receptors, differentiation and endocytosis requirements are key factors for type I IFN response by human epithelial, conventional and plasmacytoid dendritic infected cells by measles virus.
Duhen T, Herschke F, Azocar O, Druelle J, Plumet S, Delprat C, Schicklin S, Wild TF, Rabourdin-Combe C, Gerlier D, Valentin H.
Virus Res. 2010 Sep;152(1-2):115-25. doi: 10.1016/j.virusres.2010.06.013. Co-circulation of multiple measles virus genotypes during an epidemic in France in 2008.
Waku-Kouomou D, Freymuth F, du Châtelet IP, Wild TF, Horvat B.
J Med Virol. 2010 May;82(6):1033-43. doi: 10.1002/jmv.21766. Experimental infection of squirrel monkeys with nipah virus.
Marianneau P, Guillaume V, Wong T, Badmanathan M, Looi RY, Murri S, Loth P, Tordo N, Wild F, Horvat B, Contamin H.
Emerg Infect Dis. 2010 Mar;16(3):507-10. doi: 10.3201/eid1603.091346.


PolyI:C plus IL-2 or IL-12 induce IFN-gamma production by human NK cells via autocrine IFN-beta.
Duluc D, Tan F, Scotet M, Blanchard S, Frémaux I, Garo E, Horvat B, Eid P, Delneste Y, Jeannin P.
Eur J Immunol. 2009 Oct;39(10):2877-84. doi: 10.1002/eji.200838610. iNKT cell development is orchestrated by different branches of TGF-beta signaling.
Doisne JM, Bartholin L, Yan KP, Garcia CN, Duarte N, Le Luduec JB, Vincent D, Cyprian F, Horvat B, Martel S, Rimokh R, Losson R, Benlagha K, Marie JC.
J Exp Med. 2009 Jun 8;206(6):1365-78. doi: 10.1084/jem.20090127. The interaction between the measles virus nucleoprotein and the Interferon Regulator Factor 3 relies on a specific cellular environment.
Colombo M, Bourhis JM, Chamontin C, Soriano C, Villet S, Costanzo S, Couturier M, Belle V, Fournel A, Darbon H, Gerlier D, Longhi S.
Virol J. 2009 May 15;6:59. doi: 10.1186/1743-422X-6-59. Acute Hendra virus infection: Analysis of the pathogenesis and passive antibody protection in the hamster model.
Guillaume V, Wong KT, Looi RY, Georges-Courbot MC, Barrot L, Buckland R, Wild TF, Horvat B.
Virology. 2009 May 10;387(2):459-65. doi: 10.1016/j.virol.2009.03.001. Interplay between virus-specific effector response and Foxp3 regulatory T cells in measles virus immunopathogenesis.
Sellin CI, Jégou JF, Renneson J, Druelle J, Wild TF, Marie JC, Horvat B.
PLoS One. 2009;4(3):e4948. doi: 10.1371/journal.pone.0004948. Measles virus interaction with host cells and impact on innate immunity.
Gerlier D, Valentin H.
Curr Top Microbiol Immunol. 2009;329:163-91.


Generation of mice with conditionally activated transforming growth factor beta signaling through the TbetaRI/ALK5 receptor.
Bartholin L, Cyprian FS, Vincent D, Garcia CN, Martel S, Horvat B, Berthet C, Goddard-Léon S, Treilleux I, Rimokh R, Marie JC.
Genesis. 2008 Dec;46(12):724-31. doi: 10.1002/dvg.20425. Human C3 deficiency associated with impairments in dendritic cell differentiation, memory B cells, and regulatory T cells.
Ghannam A, Pernollet M, Fauquert JL, Monnier N, Ponard D, Villiers MB, Péguet-Navarro J, Tridon A, Lunardi J, Gerlier D, Drouet C.
J Immunol. 2008 Oct 1;181(7):5158-66. Refined study of the interaction between HIV-1 p6 late domain and ALIX.
Lazert C, Chazal N, Briant L, Gerlier D, Cortay JC.
Retrovirology. 2008 May 13;5:39. doi: 10.1186/1742-4690-5-39. High-density rafts preferentially host the complement activator measles virus F glycoprotein but not the regulators of complement activation.
Ghannam A, Hammache D, Matias C, Louwagie M, Garin J, Gerlier D.
Mol Immunol. 2008 Jun;45(11):3036-44. doi: 10.1016/j.molimm.2008.03.013. Wild type measles virus attenuation independent of type I IFN.
Druelle J, Sellin CI, Waku-Kouomou D, Horvat B, Wild FT.
Virol J. 2008 Feb 3;5:22. doi: 10.1186/1743-422X-5-22