Séminaire CIRI : Dr. Thomas S KUPPER

Dr. Thomas S KUPPER (MD, Department of Dermatology at Brigham and Women’s Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston (USA). " The formation and role of resident memory T cells in skin inflammatory diseases"

Abstract: Skin is our primary interface with the environment, and T cells are crucial for orchestrating host immune responses against pathogenic microorganisms at this site. Effective skin immune responses require the generation of antigen-specific effector T cells, which home to cutaneous sites of injury or infection. Long-lasting immunity against future immune challenges is mediated by memory T cells. Among the memory T cells found in skin are both recirculating cells that transit between skin and blood and tissue-resident memory T (T_RM) cells, which remain in skin for long periods of time and mediate durable protective immunity. These T_RM cells also appear to drive many inflammatory diseases of skin. Here, we consider how a better understanding of cutaneous T cell responses can aid in the development of effective new therapies for immune-mediated cutaneous diseases.

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