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You are here: Home / About us / Evenements / CIRI Seminar: Dr. Petr CHLANDA

CIRI Seminar: Dr. Petr CHLANDA

“Zooming in on replication cycle of respiratory viruses by in situ cryo-electron tomography”
When May 18, 2021
from 11:00 AM to 12:00 PM
Where visioconférence
Contact Name

Dr Petr CHLANDA (Heidelberg university): « Zooming in on replication cycle of respiratory viruses by in situ cryo-electron tomography »

Abstract: We have established an in situ cryo-correlative light and electron tomography workflow to study cellular organelles are their interactions with viruses during infection in unperturbed conditions and at a molecular resolution. This method allowed us to describe the architecture of lamellar bodies present in type II pneumocytes and to capture influenza A virus entry intermediates. In addition, our data revealed a viral RNA network inside double-membrane vesicles and assembly steps of SARS-CoV-2.