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Interleukins 15 and 18 synergistically prime the antitumor function of natural killer cells through noncanonical activation of mTORC1
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Natural killer (NK) cells have antitumor activity that is primed by IL-15 and IL-18, components of a cytokine cocktail used in NK cell–based cancer immunotherapy. Fallone et al. found that IL-15 and IL-18 synergized to activate the complex mTORC1, which resulted in increased proliferation and function of both mouse and human NK cells. IL-15 and IL-18 stimulated mTORC1 activity through distinct pathways not previously implicated in its regulation. The combination of IL-15 and IL-18 improved the survival of mice engrafted with tumor cells, suggesting a therapeutic strategy to enhance the efficacy of NK cell–based cancer immunotherapy
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Walzer T - LYACTS
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Inverted direct allorecognition triggers early donor-specific antibody responses after transplantation
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X.Charmetant, CC.Chen, S.Hamada [...] and O.Thaunat
Science Translational Medicine, 2022
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Thaunat O - NOPAB
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JEM, 2021, August 06 :Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs
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Walzer T - LYACTS
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LACC1-associated JIA linked to autophagy defects in macrophages
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Walzer T - LYACTS
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Lipoprotein receptors: A little grease for enveloped viruses to open the lock?
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François-Loïc Cosset and Solène Denolly. JBC, 2024. DOI: 10.1016/j.jbc.2024.107849
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Cosset FL - EVIR
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Loss of hepatitis D virus infectivity upon farnesyl transferase inhibitor treatment associates with increasing RNA editing rates revealed by a new RT-ddPCR method
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Verrier et al., Antiviral Research, 2022 / Team HepVir
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Durantel D - HepVir
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Quoi de neuf pour nous ?
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Lung virome convergence precedes hospital-acquired pneumonia in intubated critically ill patients
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Lung virome convergence precedes hospital-acquired pneumonia in intubated critically ill patients
Anani et al. Cell Rep Medicine - Team VirPath-CARVI
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B. Lina group
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Equipe CARVI (O. Terrier/S. Trouillet-Assant)
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Measles Virus-Imposed Remodeling of the Autophagy Machinery Determines the Outcome of Bacterial Coinfection
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Claviere M, Lavedrine A, Lamiral G, Bonnet M, Verlhac P, Petkova DS, Espert L, Duclaux-Loras R, Lucifora J, Rivoire M, Boschetti G, Nancey S, Rozières A, Viret C, Faure M. Autophagy. 2022 Jul 28.
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Faure M - APY
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mTOR Activation Underlies Enhanced B Cell Proliferation and Autoimmunity in PrkcdG510S/G510S Mice
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Moreews M ; Mathieu AL, Pouxvielh K... Marçais A, Walzer T, Belot A
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Walzer T - LYACTS
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Mucosal Vaccination with Live Attenuated Bordetella bronchiseptica Protects against Challenge in Wistar Rats
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Vaccines: Miguelena Chamorro B., De Luca K., Swaminathan G., Rochereau N., Majorel J., Poulet H. Chanut B., Piney L., Mundt E., Paul S. https://www.mdpi.com/2076-393X/11/5/982
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Paul S - GIMAP
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