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Understanding infectious diseases to better control them

The Centre International de Recherche en Infectiologie (CIRI) is a joint research unit of the Lyon 1 University, Inserm, CNRS and the ENS de Lyon in partnership with VetAgro Sup, the Institut Pasteur and the Hospices Civils de Lyon. The CIRI gathers the scientific and medical research communities with complementary disciplinary backgrounds grouped in 3 specialties working together with the objective to understand host-microbe interactions to better fight infectious diseases.

Discover the CIRI: General presentation, Teams, Teaching, Clinical research, Organization, The 3 specialties and Transversal projects, Jobs and internship offers, Contact & Localization.





Jan 21, 2022 Domain 2 of Hepatitis C Virus Protein NS5A Activates Glucokinase and Induces Lipogenesis in Hepatocytes

The team describes glucokinase activation by the NS5A protein of Hepatitis C Virus in hepatocytes, resulting in glycolysis enhancement, leading to (...)

Jan 20, 2022 Loss of hepatitis D virus infectivity upon farnesyl transferase inhibitor treatment associates with increasing RNA editing rates revealed by a new RT-ddPCR method

Verrier et al., Antiviral Research, 2022 / Team HepVir

Jan 19, 2022 TNF-α response in macrophages depends on clinical Legionella pneumophila isolates genotypes.

Guillemot et al. 2022. Virulence. doi: 10.1080/21505594.2021.2022861


Sep 10, 2021 Selective Autophagy Receptors in Antiviral Defense.

Viret C, Duclaux-Loras R, Nancey S, Rozières A, Faure M.Trends Microbiol. 2021 Sep;29(9):798-810.

Apr 19, 2021 Regulatory Networks of the T4SS Control: From Host Cell Sensing to the Biogenesis and the Activity during the Infection

Jaboulay et al. J Mol Biol 2021 April 30

Mar 30, 2021 Interplay Between CMGC Kinases Targeting SR Proteins and Viral Replication: Splicing and Beyond

Pastor F et al., Frontiers in Microbology, 2021 / Team HepVir


Last seminars

Jan 10, 2022 CIRI seminar: Dr. Damien Arnoult
Jan 06, 2022 CIRI seminar: Pr. Laurent CHATEL-CHAIX
Dec 09, 2021 CIRI seminar: Dr. Brian WEBSTER

CIRI seminar:Dr. Brian WEBSTER (Team Coordinator – Miltenyi Biotec Köln - Germany) Hote : (...)

Apr 26, 2021 Web Conférence Grand Public

La Société Francaise de Virologie vous invite à une Web Conférence Grand Public présentée (...)


Jun 15, 2022 IRCI 2022

Immune Response in Cancer and Infection


Jan 26, 2022 Kick-off meeting Equipex InfectioTron

Thesis defenses

Oct 05, 2021 PhD defense of Marion Delphin, team HepVir

Polarization of Hepatic Macrophages by HBsAg, a means to an end for viral maintenance