Science Immunology : LYACTS team publication on MIS-C syndrome
MIS-C’s unique TCR Vβ repertoire
Multiple Inflammatory Syndrome in Children (MIS-C) is a severe complication that develops in children previously infected with SARS-CoV2, with similar features to Kawasaki disease (KD) and Toxic Shock Syndrome (TSS). It is still unclear what immunologic correlates differentiate MIS-C from KD and TSS. Here, Moreews et al. looked at the circulating T cell repertoire and phenotype of 36 MIS-C, 16 KD, 58 TSS, and 42 COVID-19 patients. They found that 75% of MIS-C patients, and none from the other groups, expressed the Vβ21.3 T cell receptor β chain variable region in both CD4 and CD8 T cells. These cells had an activated and vascular patrolling phenotype but were not specific to SARS-CoV2. Together, this work shows unique T cell responses in MIS-C patients after convalescence.
Marion Moreews,Samira Khaldi-Plassart, Rémi Pescarmona, Anne-Laure Mathieu,Christophe Malcus,Sophia Djebali1,Alicia Bellomo,Olivier Dauwalder,Magali Perret,Marine Villard,Emilie Chopin,Isabelle Rouvet,Francois Vandenesch,Céline Dupieux,Robin Pouyau,Sonia Teyssedre,Margaux Guerder,Tiphaine Louazon,Anne Moulin-Zinsch,Marie Duperri,Hugues Patura,Lisa Giovannini-Chami,
Aurélie Portefaix,Behrouz Kassai,Fabienne Venet,Guillaume Monneret,Christine Lombard,Hugues Flodrops,Jean-Marie De Guillebon,Fanny Bajolle,Valérie Launay,Paul Bastard,Shen-Ying Zhang,Valérie Dubois,Olivier Thaunat,Jean-Christophe Richard,Mehdi Mezidi, Omran Allatif,Kahina Saker,Marlène Dreux,Laurent Abel,Jean-Laurent Casanova,Jacqueline Marvel,Sophie Trouillet-Assant,David Klatzmann,Thierry Walzer,Encarnita Mariotti-Ferrandiz,Etienne Javouhey and Alexandre Belot