Publications

HighlightS :

PTPN2 deficiency: Amping up JAK/STAT

Joshua M Tobin, Megan A Cooper : JEM editors selected the last publication from Belot A. and Mathieu A.L (LYACTS Team) for a highlight article

JEM, Sept 24

More on Pre-Covid-19, SARS-CoV-2-Negative MIS-C. Reply

Sarah Benezech, Liliane Khoryati, Alexandre Belot

N Engl J Med 2024, Feb 22

Pre–Covid-19, SARS-CoV-2–Negative Multisystem Inflammatory Syndrome in Children

Sarah Benezech, Liliane Khoryati, Jade Cognard, Stejara A Netea, Taushif Khan, Marion Moreews, Kahina Saker, Jean-Marie De Guillebon, Samira Khaldi-Plassart, Rémi Pescarmona, Sebastien Viel, Christophe Malcus, Magali Perret, Meriadeg Ar Gouilh, Astrid Vabret, Fabienne Venet, Solenn Remy, Emilie Chopin, Gérard Lina, François Vandenesch, Noëmi Rousseaux, Paul Bastard, Shen-Ying Zhang, Jean-Laurent Casanova, Sophie Trouillet-Assant, Thierry Walzer, Taco W Kuijpers, Etienne Javouhey, Olivier Dauwalder, Nico Marr, Alexandre Belot

N Engl J Med 2023, Nov 30

MAJOR PUBLICATIONS :

2024 :

Tumor-induced natural killer cell dysfunction is a rapid and reversible process uncoupled from the expression of immune checkpoints

Kévin Pouxvielh, Marie Marotel, Annabelle Drouillard, Marine Villard, Marion Moreews, Anna Bossan, Mathilde Poiget, Liliane Koryati, Sarah Benezech, Lucie Fallone, Sarah Hamada, Noémi Rousseaux, Louis Picq, Yamila Rocca, Aurore Berton, Marine Teixeira, Anne-Laure Mathieu, Michelle Ainouze, Uzma Hassan, Alain Fournier, Olivier Thaunat, Antoine Marçais and Thierry Walzer

Science Advances , 2024, Aug 28

Haploinsufficiency in PTPN2 leads to early-onset systemic autoimmunity from Evans syndrome to lupus

Marie Jeanpierre, Jade Cognard, Maud Tusseau, Alexandre Belot, Anne-Laure Mathieu

The Journal of Experimental Medicine, 2024, Sept 2

2023 :

Pre-Covid-19, SARS-CoV-2-Negative Multisystem Inflammatory Syndrome in Children

Sarah Benezech, Liliane Khoryati, Jade Cognard, Stejara A Netea, Taushif Khan, Marion Moreews, Kahina Saker, Jean-Marie De Guillebon, Samira Khaldi-Plassart, Rémi Pescarmona , Sebastien Viel, Christophe Malcus, Magali Perret, Meriadeg Ar Gouilh, Astrid Vabret, Fabienne Venet, Solenn Remy, Emilie Chopin, Gérard Lina, François Vandenesch, Noëmi Rousseaux, Paul Bastard, Shen-Ying Zhang, Jean-Laurent Casanova, Sophie Trouillet-Assant, Thierry Walzer, Taco W Kuijpers, Etienne Javouhey, Olivier Dauwalder, Nico Marr, Alexandre Belot

New England Journal of Medicine, 2023, Nov 30

mTOR Activation Underlies Enhanced B Cell Proliferation and Autoimmunity in Prkcd^G510S/G510S Mice

Marion Moreews, Anne-Laure Mathieu, Kevin Pouxvielh, Alexandre Belot

The Journal of Immunology, 2023, May 1

2022 :

EOMES and T-BET, a dynamic duo regulating NK cell differenciation

Jiang Zhang, Noémi Rousseaux, Thierry Walzer

Bioessays, 2022, January 13

DNASE1L3 deficiency, new phenotypes, and evidence for a transient type I IFN signaling

Tusseau M, Lovšin E, Samaille C, Pescarmona R, Mathieu AL, Maggio MC, Selmanović V, Debeljak M, Dachy A, Novljan G, Janin A, Januel L, Gibier JB, Chopin E, Rouvet I, Goncalves D, Fabien N, Rice GI, Lesca G, Labalme A, Romagnani P, Walzer T, Viel S, Perret M, Crow YJ, Avčin T, Cimaz R, Belot A.

J Clin Immunol, 2022, June 7

Combinatorial Expression of NK Cell Receptors Governs Cell Subset Reactivity and Effector Functions but Not Tumor Specificity

Rocca Y., Pouxvielh K., Marotel M., Benezech S., Jaeger B., Allatif O., Bendriss-Vermare N., Marçais A., Walzer T.

J Immunol., 2022, April 11

2021 :

Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells

Jiang Zhang, Stéphanie Le Gras, Kevin Pouxvielh, Fabrice Faure, Lucie Fallone, Nicolas Kern, Marion Moreews, Anne-Laure Mathieu, Raphaël Schneider, Quentin Marliac, Mathieu Jung, Aurore Berton, Simon Hayek, Pierre-Olivier Vidalain, Antoine Marçais, Garvin Dodard, Anne Dejean, Laurent Brossay, Yad Ghavi-Helm, Thierry Walzer

Nature communications, 2021, September 14

Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs

Jonathan Lopez Marine Mommert, William Mouton, Andrés Pizzorno , Karen Brengel-Pesce, Mehdi Mezidi , Marine Villard, Bruno Lina, Jean-Christophe Richard, Jean-Baptiste Fassier, Valérie Cheynet , Blandine Padey , Victoria Duliere, Thomas Julien, Stéphane Paul, Paul Bastard, Alexandre Belot, Antonin Bal, Jean-Laurent Casanova, Manuel Rosa-Calatrava, Florence Morfin, Thierry Walzer, Sophie Trouillet-Assant

JEM, 2021, August 06

Polyclonal expansion of TCR Vbeta 21.3+ CD4+ and CD8+ T cells is a hallmark of Multisystem Inflammatory Syndrome in Children

Marion Moreews,Samira Khaldi-Plassart, Rémi Pescarmona, Anne-Laure Mathieu,Christophe Malcus,Sophia Djebali1,Alicia Bellomo,Olivier Dauwalder,Magali Perret,Marine Villard,Emilie Chopin,Isabelle Rouvet,Francois Vandenesh,Céline Dupieux,Robin Pouyau,Sonia Teyssedre,Margaux Guerder,Tiphaine Louazon,Anne Moulin-Zinsch,Marie Duperri,Hugues Patura,Lisa Giovannini-Chami, Aurélie Portefaix,Behrouz Kassai,Fabienne Venet,Guillaume Monneret,Christine Lombard,Hugues Flodrops,Jean-Marie De Guillebon,Fanny Bajolle,Valérie Launay,Paul Bastard,Shen-Ying Zhang,Valérie Dubois,Olivier Thaunat,Jean-Christophe Richard,Mehdi Mezidi, Omran Allatif,Kahina Saker,Marlène Dreux,Laurent Abel,Jean-Laurent Casanova,Jacqueline Marvel,Sophie Trouillet-Assant,David Klatzmann,Thierry Walzer,Encarnita Mariotti-Ferrandiz,Etienne Javouhey and Alexandre Belot

Science Immunology, 2021, May 25

Cutting Edge: mTORC1 Inhibition in Metastatic Breast Cancer Patients Negatively Affects Peripheral NK Cell Maturation and Number

Laurie Besson, Benoite Mery, Magali Morelle, Yamila Rocca, Pierre Etienne Heudel, Benoit You, Thomas Bachelot, Isabelle Ray-Coquard, Marine Villard, Emily Charrier, François Parant, Sébastien Viel, Gwenaële Garin, Romaine Mayet, David Perol, Thierry Walzer, Olivier Tredan and Antoine Marçais

J Immunol, 2021, May 15

LACC1 deficiency links juvenile arthritis with autophagy and metabolism in macrophages

Ommar Omarjee, Anne-Laure Mathieu, Gaëlle Quiniou, Marion Moreews, Michelle Ainouze, Cécile Frachette, Isabelle Melki, Cécile Dumaine, Mathieu Gerfaud-Valentin, Agnès Duquesne, Tilmann Kallinich, Eda Tahir Turanli, Christophe Malcus, Sébastien Viel, Rémi Pescarmona, Sophie Georgin-Lavialle, Yvan Jamilloux, Jean-Paul Larbre, Guillaume Sarrabay , Flora Magnotti, Gillian I. Rice, Francoise Bleicher, Jonathan Reboulet, Samir Merabet, Thomas Henry, Yanick J. Crow, Mathias Faure, Thierry Walzer, Alexandre Belot

JEM, 2021, February 19

Peripheral natural killer cells in chronic hepatitis B patients display multiple molecular features of T cell exhaustion

Marie Marotel, Marine Villard, Annabelle Drouillard, Issam Tout, Laurie Besson, Omran Allatif, Marine Pujol, Yamila Rocca, Michelle Ainouze, Guillaume Roblot, Sébastien Viel, Melissa Gomez, Veronique Loustaud, Sophie Alain, David Durantel, Thierry Walzer, Uzma Hasan, Antoine Marçais

eLife, 2021, January 28

2020 :

Early-onset autoimmunity associated with SOCS1 haploinsufficiency

Jérôme Hadjadj, Carla Castro, Maud Tusseau, Marie-Claude Stolzenberg, Fabienne Mazerolles, Nathalie Aladjidi, Marting Amstrong, Houman Ashrafian, Ioana Cutcutache, Georg Ebetsberger-Dachs, Katherine S Elliott, Nicole Fabien, Mathieu Fusaro, Maximilian Heeg, Imagine Genomics core facility, Imagine Bioinformatics, Julian Knight, Jean-Christophe Lega, Gaétan Lesca, Anne-Laure Mathieu, Marion Moreews, Baptiste Moreira, Matthew Page, Cécile Picard, Timothy Ronan Leahy, Isabelle Rouvet, Ethel Ryan, Damien Sanlaville, Klaus Schwarz, Andrew Skelton, Jean-Francois Viallard, Sebastien Viel, Marine Villard, Isabelle Callebaut, Capucine Picard, Thierry Walzer, Stephan Ehl, Alain Fischer, Bénédicte Neven, Alexandre Belot, Frédéric Rieux-Laucat

Nat. Com., 2020, October 21

Type I IFN immunoprofiling in COVID-19 patients

Sophie Trouillet-Assant, Sebastien Viel, Alexandre Gaymard, Sylvie Pons, Jean-Christophe Richard, Magali Perret, Marine Villard, Karen Brengel-Pesce, Bruno Lina, Mehdi Mezidi, Laurent Bitker, Alexandre Belot

JACI, 2020, July 01

Zeb1 represses TCR signaling, promotes the proliferation of T cell progenitors and is essential for NK1.1 + T cell development

Jiang Zhang, Mélanie Wencker, Quentin Marliac, Aurore Berton, Uzma Hasan, Raphaël Schneider, Daphné Laubreton, Dylan E. Cherrier, Anne-Laure Mathieu, Amaury Rey, Wenzheng Jiang, Julie Caramel, Laurent Genestier, Antoine Marçais, Jacqueline Marvel, Yad Ghavi-Helm &Thierry Walzer

Cellular & Molecular Immunology, 2020, May 12

Contribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts

Prof Alexandre Belot, Gillian I Rice, Sulliman Ommar Omarjee, Quentin Rouchon, Eve M D Smith, Marion Moreews, Maud Tusseau, Cécile Frachette, Raphael Bournhonesque, Nicole Thielens, Christine Gaboriaud, Isabelle Rouvet, Emilie Chopin, Akihiro Hoshino, PhDSylvain Latour, Bruno Ranchin, Rolando Cimaz, Paula Romagnani, Christophe Malcus, Nicole Fabien, Marie-Nathalie Sarda, Behrouz Kassai, Jean-Christophe Lega, Stéphane Decramer, Pauline Abou-Jaoude, Prof Ian N Bruce, Thomas Simonet, Claire Bardel, Pierre Antoine Rollat-Farnier, Sebastien Viel, Héloise Reumaux, James O'Sullivan, Thierry Walzer, Anne-Laure Mathieu, Gaelle Marenne, Thomas Ludwig, Emmanuelle Genin, Jamie Ellingford, Brigitte Bader-Meunier, Tracy A Briggs, Michael W Beresford, Yanick J Crow

The Lancet Rheumatology, 2020, January 13

2019 :

Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants

Koenig A, Chen CC, Marçais A, Mathias V, Sicard A, Rabeyrin M, Racapé M, Duong-Van-Huyen JP, Bruneval P, Loupy A, Dussurgey S, Ducreux S, Paidassi H, Guillemain R, Taupin JL, Morelon E, Nicoletti A, Charreau B, Dubois V, Walzer T, Defrance T, Thaunat O

Nature Communications, 2019 November 25

2018 :

Auto-inflammatory diseases and familial hemophagocytic lymphohistiocytosis promote macrophage activation syndrome through distinct mechanisms

Fauteux-Daniel S, Viel S, Besson L, Zhang J, Marotel M, Mathieu AL, Pescarmona R, Charrier E, Henry T, Belot A and Walzer T

Journal of Immunology, 2018 June 1

Human Naive and Memory T Cells Display Opposite Migratory Responses to Sphingosine-1 Phosphate

Annabelle Drouillard, Antoinette Neyra, Anne-Laure Mathieu, Antoine Marçais, Mélanie Wencker, Jacqueline Marvel, Alexandre Belot and Thierry Walzer

The Journal of Immunology, 2018 January 15

2017 :

High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors

Antoine Marçais, Marie Marotel, Sophie Degouve, Alice Koenig, Sébastien Fauteux-Daniel, Annabelle Drouillard, Heinrich Schlums, Sébastien Viel Laurie Besson, Omran Allatif, Mathieu Bléry, Eric Vivier, Yenan Bryceson, Olivier Thaunat, Thierry Walzer

eLife, 2017, September 6

2016 :

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway

Sébastien Viel, Antoine Marçais, Fernando Souza-Fonseca Guimaraes, Roisin Loftus, Jessica Rabilloud, Morgan Grau, Sophie Degouve, Sophia Djebali, Amélien Sanlaville, Emily Charrier, Jacques Bienvenu, Julien C. Marie, Christophe Caux, Jacqueline Marvel, Liam Town, Nicholas D. Huntington, Laurent Bartholin, David Finlay, Mark J. Smyth, Thierry Walzer

Science Signaling, 2016, February 16

2015 :

PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity

Anne-Laure Mathieu, Estelle Verronese, Gillian I Rice, Fanny Fouyssac, Yves Bertrand, Capucine Picard, Marie Chansel, Jolan E Walter, Luigi D Notarangelo, Manish J Butte, Kari Christine Nadeau, Krisztian Csomos, David J Chen, Karin Chen, Ana Delgado, Chantal Rigal, Christine Bardin, Catharina Schuetz, Despina Moshous, Héloïse Reumaux, François Plenat, Alice Phan, Marie-Thérèse Zabot, Brigitte Balme, Sébastien Viel, Jacques Bienvenu, Pierre Cochat, Mirjam van der Burg, Christophe Caux, E Helen Kemp, Isabelle Rouvet, Christophe Malcus, Jean-Francois Méritet, Annick Lim, Yanick J Crow, Nicole Fabien, Christine Ménétrier-Caux, Jean-Pierre De Villartay, Thierry Walzer, Alexandre Belot

JACI, 2015, June 01

2014 :

The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells

Antoine Marçais, Julien Cherfils-Vicini, Charlotte Viant, Sophie Degouve, Sébastien Viel, Aurore Fenis, Jessica Rabilloud, Katia Mayol, Armelle Tavares, Jacques Bienvenu, Yann-Gaël Gangloff, Eric Gilson, Eric Vivier &Thierry Walzer

Nature Immunology, 2014, June 29

T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow.

Cécile Daussy 1 , Fabrice Faure, Katia Mayol, Sébastien Viel, Georg Gasteiger, Emily Charrier, Jacques Bienvenu, Thomas Henry, Emilie Debien, Uzma A Hasan, Jacqueline Marvel, Keigyou Yoh, Satoru Takahashi, Immo Prinz, Simon de Bernard, Laurent Buffat, Thierry Walzer

JEM, 2014, February 10

Lien pour la liste complète des publications :

Lien Pubmed Thierry Walzer

Lien Google Scholar Alexandre Belot

Navigation

Tutelles

Tutelles secondaires

Publications

HighlightS :

MAJOR PUBLICATIONS :

Contacts