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You are here: Home / Teams / Cimarelli A - LP2L / Publications



The inflammatory and tumor suppressor SAMD9L acts through a Schlafen-like box to restrict HIV and inhibit cell translation in SAAD/ATXPC.
Legrand A, Dahoui C, De La Myre Mory C, Loyer C, Noy K, Guiguettaz L, Pillon M, Wcislo M, Guéguen L, Cimarelli A, Mateo M, Fiorini F, Ricci E, Etienne L.
bioRxiv 2023 Jan 19. doi:




Adaptive duplication and genetic diversification of protein kinase R contribute to the specificity of bat-virus interactions.
Jacquet S, Culbertson M, Zhang C, El Filali A, De La Myre Mory C, Pons JB, Filippi-Codaccioni O, Lauterbur ME, Ngoubangoye B, Duhayer J, Verez C, Park C, Dahoui C, Carey CM, Brennan G, Enard D, Cimarelli A, Rothenburg S, Elde NC, Pontier D, Etienne L.
Science Advances. 2022 Nov 25;8(47):eadd7540. doi: 10.1126/sciadv.add7540. Epub 2022 Nov 23. PMID: 36417524

Trim69 is a microtubule regulator that acts as a pantropic viral inhibitor.
Song Y, Nguyen XN, Kumar A, da Silva C, Picard L, Etienne L, Cimarelli A.
Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2211467119. doi: 10.1073/pnas.2211467119. Epub 2022 Oct 17. PMID: 36251989

Distinct evolutionary trajectories of SARS-CoV-2-interacting proteins in bats and primates identify important host determinants of COVID-19.
Cariou M, Picard L, Guéguen L, Jacquet S, Cimarelli A, Fregoso OI, Molaro A, Navratil V, Etienne L.
Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2206610119. doi: 10.1073/pnas.2206610119. Epub 2022 Aug 10. PMID: 35947637
ISG20: an enigmatic antiviral RNase targeting multiple viruses.
Deymier S, Louvat C, Fiorini F, Cimarelli A.
FEBS Open Bio. 2022 Jun;12(6):1096-1111. doi: 10.1002/2211-5463.13382. Epub 2022 Feb 27. PMID: 35174977
A novel domain within the CIL regulates egress of IFITM3 from the Golgi and reveals a regulatory role of IFITM3 on the secretory pathway.
Zhong L, Song Y, Marziali F, Uzbekov R, Nguyen XN, Journo C, Roingeard P, Cimarelli A.
Life Sci Alliance. 2022 Apr 8;5(7):e202101174. doi: 10.26508/lsa.202101174. Print 2022 Jul. PMID: 35396335


Functional heterogeneity of mammal IFITM proteins against HIV-1.
Federico Marziali, Mathilde Delpeuch, Anuj Kumar, Romain Appourchaux, Jérémy Dufloo, Kevin Tartour, Lucie Etienne, Andrea Cimarelli.
Journal of Virology 2021 Jun 23:JVI0043921.

A Conserved uORF Regulates APOBEC3G Translation and Is Targeted by HIV-1 Vif Protein to Repress the Antiviral Factor.
Libre C, Seissler T, Guerrero S, Batisse J, Verriez C, Stupfler B, Gilmer O, Cabrera-Rodriguez R, Weber MM, Valenzuela-Fernandez A, Cimarelli A, Etienne L, Marquet R, Paillart JC.
Biomedicines. 2021 Dec 22;10(1):13. doi: 10.3390/biomedicines10010013. PMID: 35052693


Rapid Evolution of HERC6 and Duplication of a Chimeric HERC5/6 Gene in Rodents and Bats Suggest an Overlooked Role of HERCs in Mammalian Immunity.
Jacquet S, Pontier D, Etienne L.
Front Immunol. 2020 Dec 18;11:605270. doi: 10.3389/fimmu.2020.605270. eCollection 2020

DGINN, an automated and highly-flexible pipeline for the Detection of Genetic INNovations on protein-coding genes.
Picard L, Ganivet Q, Allatif O, Cimarelli A, Guéguen L*, Etienne L*.
Nucleic Acid Research. 2020, gkaa680

Program : DGINN.


The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation.
Wu N, Nguyen XN, Wang L, Appourchaux R, Zhang C, Panthu B, Gruffat H, Journo C, Alais S, Qin J, Zhang N, Tartour K, Catez F, Mahieux R, Ohlmann T, Liu M, Du B, Cimarelli A.
PLoS Pathog. 2019 Oct 10;15(10):e1008093. doi: 10.1371/journal.ppat.1008093. eCollection 2019 Oct.

The DNA damage induced by the Cytosine Deaminase APOBEC3A Leads to the production of Ros.
Mathilde Niocel, Romain Appourchaux, Xuan-Nhi Nguyen, Mathilde Delpeuch & Andrea Cimarelli
Scientific reports. 2019.

[Noise from Vpx: “HUSH”!]
Chougui G, Martin M, Matkovic R, Etienne L, Margottin-Goguet F.
Med Sci (Paris). 2019 Jan;35(1):9-12. doi: 10.1051/medsci/2018312. Epub 2019 Jan 23. French. No abstract available.

Evolution of Hepatitis B Virus Receptor NTCP Reveals Differential Pathogenicities and Species Specificities of Hepadnaviruses in Primates, Rodents, and Bats.
Jacquet S, Pons JB, De Bernardo A, Ngoubangoye B, Cosset FL, Régis C, Etienne L*, Pontier D*.
J Virol. 2019 Feb 19;93(5). pii: e01738-18. doi: 10.1128/JVI.01738-18.

Functional Mapping of Regions Involved in the Negative Imprinting of Virion Particle Infectivity and in Target Cell Protection by Interferon-Induced Transmembrane Protein 3 against HIV-1.
Appourchaux R, Delpeuch M, Zhong L, Burlaud-Gaillard J, Tartour K, Savidis G, Brass A, Etienne L, Roingeard P, Cimarelli A.
J Virol. 2019 Jan 4;93(2). pii: e01716-18. doi: 10.1128/JVI.01716-18.


NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation.
Lahaye X, Gentili M, Silvin A, Conrad C, Picard L, Jouve M, Zueva E, Maurin M, Nadalin F, Knott GJ, Zhao B, Du F, Rio M, Amiel J, Fox AH, Li P, Etienne L, Bond CS, Colleaux L, Manel N.
Cell. 2018 Oct 4;175(2):488-501.e22. doi: 10.1016/j.cell.2018.08.062. Epub 2018 Sep 27.

HIV-2/SIV viral protein X counteracts HUSH repressor complex.
Chougui G, Munir-Matloob S, Matkovic R, Martin MM, Morel M, Lahouassa H, Leduc M, Ramirez BC, Etienne L, Margottin-Goguet F.
Nature Microbiol. 2018 Aug;3(8):891-897. doi: 10.1038/s41564-018-0179-6.

Smc5/6 Antagonism by HBx Is an Evolutionarily Conserved Function of Hepatitis B Virus Infection in Mammals.
Abdul F, Filleton F, Gerossier L, Paturel A, Hall J, Strubin M, Etienne L.
J Virol. 2018 Jul 31;92(16). pii: e00769-18. doi: 10.1128/JVI.00769-18. Print 2018 Aug 15

Mannoside Glycolipid Conjugates Display Antiviral Activity Against Ebola Virus.
Reynard O, Schaeffer E, Volchkova VA, Cimarelli A, Mueller CG, Volchkov VE.
J Infect Dis. 2018 Nov 22;218(suppl_5):S666-S671. doi: 10.1093/infdis/jiy464.


Interference with the production of infectious viral particles and bimodal inhibition of replication are broadly conserved antiviral properties of IFITMs.
Tartour K, Nguyen XN, Appourchaux R, Assil S, Barateau V, Bloyet LM, Burlaud Gaillard J, Confort MP, Escudero-Perez B, Gruffat H, Hong SS, Moroso M, Reynard O, Reynard S, Decembre E, Ftaich N, Rossi A, Wu N, Arnaud F, Baize S, Dreux M, Gerlier D, Paranhos-Baccala G, Volchkov V, Roingeard P, Cimarelli A.
PLoS Pathog. 2017 Sep 28;13(9):e1006610. doi: 10.1371/journal.ppat.1006610

Leucine-rich repeat-containing G protein-coupled receptor 4 facilitates vesicular stomatitis virus infection by binding vesicular stomatitis virus glycoprotein.
Zhang N, Huang H, Tan B, Wei Y, Xiong Q, Yan Y, Hou L, Wu N, Siwko S, Cimarelli A, Xu J, Han H, Qian M, Liu M, Du B.
J Biol Chem. 2017 Aug 23. pii: jbc.M117.802090. doi: 10.1074/jbc.M117.802090.


A Novel Entry/Uncoating Assay Reveals the Presence of at Least Two Species of Viral Capsids During Synchronized HIV-1 Infection.
Da Silva Santos C, Tartour K, Cimarelli A.
PLoS Pathog. 2016 Sep 30;12(9):e1005897. doi: 10.1371/journal.ppat.1005897.

[New participants in the antiviral response: identification of a negative regulator of the factor IFITM3].
Appourchaux R, Cimarelli A.
Med Sci (Paris). 2016 Apr;32(4):320-3. doi: 10.1051/medsci/20163204003

Duplication as a source of genetic innovation for “antiviral genes”
Wcislo M and Etienne L.
Virologie. 2016 Jul; 20(4) :207-17. [French]


The Frequency of Cytidine Editing of Viral DNA Is Differentially Influenced by Vpx and Nucleosides during HIV-1 or SIVMAC Infection of Dendritic Cells.
Nguyen XN, Barateau V, Wu N, Berger G, Cimarelli A.
PLoS One. 2015 Oct 23;10(10):e0140561.

The Role of the Antiviral APOBEC3 Gene Family in Protecting Chimpanzees against Lentiviruses from Monkeys.
Etienne L, Bibollet-Ruche F, Sudmant PH, Wu LI, Hahn BH, Emerman M.
PLoS Pathog. 2015 Sep 22;11(9):e1005149.

Virus-host evolution and Positive selection.
Etienne L.
Encyclopedia of AIDS. Springer New York. 2015. pp1-13.

The susceptibility of primate lentiviruses to nucleosides and Vpx during infection of dendritic cells is regulated by CA.
Barateau V, Nguyen XN, Bourguillault F, Berger G, Cordeil S, Cimarelli A.
J Virol. 2015 Apr;89(7):4030-4.

Origin of the HIV-1 group O epidemic in western lowland gorillas.
D’arc M, Ayouba A, Esteban A, Learn GH, Boué V, Liegeois F, Etienne L, Tagg N, Leendertz FH, Boesch C, Madinda NF, Robbins MM, Gray M, Cournil A, Ooms M, Letko M, Simon VA, Sharp PM, Hahn BH, Delaporte E, Mpoudi Ngole E, Peeters M.
Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1343-52.


IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity.
Tartour K, Appourchaux R, Gaillard J, Nguyen XN, Durand S, Turpin J, Beaumont E, Roch E, Berger G, Mahieux R, Brand D, Roingeard P, Cimarelli A.
Retrovirology. 2014 Nov 25;11(1):103. [Epub ahead of print]

SIVSM/HIV-2 Vpx Proteins : Function and Uses in the Infection of Primary Myeloid Cells.
G. Berger and A. Cimarelli.
Methods Mol Biol.  2014;1087:159-165.

HIV-1 Reverse Transcription.
A. Cimarelli and J.L. Darlix.
Methods  Mol Biol. 2014;1087:55-70.


The mongoose, the pheasant, the pox, and the retrovirus.
Etienne L, Emerman M.
PLoS Biol. 2013;11(8):e1001641.

Gene loss and adaptation to hominids underlie the ancient origin of HIV-1.
Etienne L, Hahn BH, Sharp PM, Matsen FA, Emerman M.
Cell Host Microbe. 2013 Jul 17;14(1):85-92.

Evidence for a different susceptibility of primate lentiviruses to type I interferons.
Cordeil S, Nguyen XN, Berger G, Durand S, Ainouze M, Cimarelli A.
J Virol. 2013 Mar;87(5):2587-96. doi: 10.1128/JVI.02553-12.

Single real-time reverse transcription-PCR assay for detection and quantification of genetically diverse HIV-1, SIVcpz, and SIVgor strains.
Etienne L, Eymard-Duvernay S, Aghokeng A, Butel C, Monleau M, Peeters M.
J Clin Microbiol. 2013 Mar;51(3):787-98

Tailored HIV-1 vectors for genetic modification of primary human dendritic cells and monocytes.
Durand S, Nguyen XN, Turpin J, Cordeil S, Nazaret N, Croze S, Mahieux R, Lachuer J, Legras-Lachuer C, Cimarelli A.
J Virol. 2013 Jan;87(1):234-42. doi: 10.1128/JVI.01459-12.


Functional analysis of the relationship between Vpx and the restriction factor SAMHD1.
Berger G, Turpin J, Cordeil S, Tartour K, Nguyen XN, Mahieux R, Cimarelli A.
J Biol Chem. 2012 Nov 30;287(49):41210-7. doi: 10.1074/jbc.M112.403816.

Noninvasive follow-up of simian immunodeficiency virus infection in wild-living nonhabituated western lowland gorillas in Cameroon.
Etienne L, Locatelli S, Ayouba A, Esteban A, Butel C, Liegeois F, Aghokeng A, Delaporte E, Mpoudi Ngole E, Peeters M.
J Virol. 2012 Sep;86(18):9760-72.

Simian immunodeficiency virus-Vpx for improving integrase defective lentiviral vector-based vaccines.
Negri DR, Rossi A, Blasi M, Michelini Z, Leone P, Chiantore MV, Baroncelli S, Perretta G, Cimarelli A, Klotman ME, Cara A.
Retrovirology. 2012 Aug 22;9:69. doi: 10.1186/1742-4690-9-69.

The transcription profile of Tax-3 is more similar to Tax-1 than Tax-2: insights into HTLV-3 potential leukemogenic properties.
Chevalier SA, Durand S, Dasgupta A, Radonovich M, Cimarelli A, Brady JN, Mahieux R, Pise-Masison CA.
PLoS One. 2012;7(7):e41003. doi: 10.1371/journal.pone.0041003.

Different effects of the TAR structure on HIV-1 and HIV-2 genomic RNA translation.
Soto-Rifo R, Limousin T, Rubilar PS, Ricci EP, Décimo D, Moncorgé O, Trabaud MA, André P, Cimarelli A, Ohlmann T.
Nucleic Acids Res. 2012 Mar;40(6):2653-67. doi: 10.1093/nar/gkr1093.

Functional mechanisms of the cellular prion protein (PrP(C)) associated anti-HIV-1 properties.
Alais S, Soto-Rifo R, Balter V, Gruffat H, Manet E, Schaeffer L, Darlix JL, Cimarelli A, Raposo G, Ohlmann T, Leblanc P.
Cell Mol Life Sci. 2012 Apr;69(8):1331-52. doi: 10.1007/s00018-011-0879-z.


The inside out of lentiviral vectors.
Durand S, Cimarelli A.
Viruses. 2011 Feb;3(2):132-59. doi: 10.3390/v3020132.

APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.
Berger G, Durand S, Fargier G, Nguyen XN, Cordeil S, Bouaziz S, Muriaux D, Darlix JL, Cimarelli A.
PLoS Pathog. 2011 Sep;7(9):e1002221. doi: 10.1371/journal.ppat.1002221.

A simple, versatile and efficient method to genetically modify human monocyte-derived dendritic cells with HIV-1-derived lentiviral vectors.
Berger G, Durand S, Goujon C, Nguyen XN, Cordeil S, Darlix JL, Cimarelli A.
Nat Protoc. 2011 Jun;6(6):806-16. doi: 10.1038/nprot.2011.327.

Molecular insight into how HIV-1 Vpr protein impairs cell growth through two genetically distinct pathways.
Maudet C, Bertrand M, Le Rouzic E, Lahouassa H, Ayinde D, Nisole S, Goujon C, Cimarelli A, Margottin-Goguet F, Transy C.
J Biol Chem. 2011 Jul 8;286(27):23742-52. doi: 10.1074/jbc.M111.220780.

Characterization of a new simian immunodeficiency virus strain in a naturally infected Pan troglodytes troglodytes chimpanzee with AIDS related symptoms.
Etienne L, Nerrienet E, LeBreton M, Bibila GT, Foupouapouognigni Y, Rousset D, Nana A, Djoko CF, Tamoufe U, Aghokeng AF, Mpoudi-Ngole E, Delaporte E, Peeters M, Wolfe ND, Ayouba A.
Retrovirology. 2011 Jan 13;8:4.
* Comment Findings: More evidence that chimps die from AIDS.
Science. 2011, 331(6022):1249.


Journey to the heart of macrophages: the delicate relationship between HIV-1 and a multifaceted cell type.
Cimarelli A.
Retrovirology. 2010 Apr 7;7:28. doi: 10.1186/1742-4690-7-28.

Implications of the nucleocapsid and the microenvironment in retroviral reverse transcription.
Mougel M, Cimarelli A, Darlix JL.
Viruses. 2010 Apr;2(4):939-60. doi: 10.3390/v2040939.

Analysis of the viral elements required in the nuclear import of HIV-1 DNA.
Rivière L, Darlix JL, Cimarelli A.
J Virol. 2010 Jan;84(2):729-39. doi: 10.1128/JVI.01952-09.


Characterization of the behavior of functional viral genomes during the early steps of human immunodeficiency virus type 1 infection.
Arfi V, Lienard J, Nguyen XN, Berger G, Rigal D, Darlix JL, Cimarelli A.
J Virol. 2009 Aug;83(15):7524-35. doi: 10.1128/JVI.00429-09.

Improved adenovirus type 5 vector-mediated transduction of resistant cells by piggybacking on coxsackie B-adenovirus receptor-pseudotyped baculovirus.
Granio O, Porcherot M, Corjon S, Kitidee K, Henning P, Eljaafari A, Cimarelli A, Lindholm L, Miossec P, Boulanger P, Hong SS.
J Virol. 2009 Jun;83(12):6048-66. doi: 10.1128/JVI.00012-09.

SIVMAC Vpx improves the transduction of dendritic cells with nonintegrative HIV-1-derived vectors.
Berger G, Goujon C, Darlix JL, Cimarelli A.
Gene Ther. 2009 Jan;16(1):159-63. doi: 10.1038/gt.2008.128.


Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cells.
Goujon C, Arfi V, Pertel T, Luban J, Lienard J, Rigal D, Darlix JL, Cimarelli A.
J Virol. 2008 Dec;82(24):12335-45. doi: 10.1128/JVI.01181-08.

Characterization of the early steps of infection of primary blood monocytes by human immunodeficiency virus type 1.
Arfi V, Rivière L, Jarrosson-Wuillème L, Goujon C, Rigal D, Darlix JL, Cimarelli A.
J Virol. 2008 Jul;82(13):6557-65. doi: 10.1128/JVI.02321-07.