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Overview

Primate lentiviruses are a group of closely related viruses that have infected their primate hosts for millions of years and that in humans gave recently raise to the emergence of  the human immunodeficiency type 1 and type 2 viruses (HIV-1 and HIV-2) responsible for the acquired immunodeficiency syndrome (AIDS) pandemic.

Our laboratory is interested in understanding the molecular and evolutionary mechanisms at the basis of HIV replication in its primary cell targets and in elucidating how the virus accommodates with cellular antiviral responses. Using HIV as a starting point, we have more recently become interested also in determining whether specific anti-HIV processes could also be directed, or re-directed, against other viruses of interest for public health.

Work in our laboratory is focused around two major axes of research:

Axis 1 (PI: A. Cimarelli): Identification and characterization of cellular factors that modulate HIV replication and extrapolation to other RNA viruses
 
Axis 2 (PI: L. Etienne): Evolution of virus-host interactions and impact on cross-species transmission

http://ciri.inserm.fr/files/2016/10/WebFig1.jpg

Funding (in alphabetical order):
amfAR, ANR, ANRS, CNRS, FINOVI, FRM, JoRISS, LabEx ECOFECT, Région Auvergne Rhône Alpes, Sidaction