Publications

NDP52 mediates an antiviral response to hepatitis B virus infection through Rab9-dependent lysosomal degradation pathway.

Cui S, Xia T, Zhao J, Ren X, Wu T, Kameni M, Guo X, He L, Guo J, Duperray-Susini A, Levillayer F, Collard JM, Zhong J, Pan L, Tangy F, Vidalain PO, Zhou D, Jiu Y, Faure M, Wei Y. Nat Commun. 2023 Dec 19;14(1):8440. doi: 10.1038/s41467-023-44201-2.

[Role of cellular metabolism in the control of chronic viral hepatitis].

Olivier Diaz, Anne-Flore Legrand*, Walid El-Orch*, Florentine Jacolin*, Vincent Lotteau, Christophe Ramière, Pierre-Olivier Vidalain & Laure Perrin-Cocon. Med Sci (Paris). 2023 Oct;39(10):754-762. doi: 10.1051/medsci/2023125. French.

Farnesoid X receptor alpha ligands inhibit HDV in vitro replication and virion infectivity.
Legrand AF, Lucifora J, Lacombe B, Ménard C, Michelet M, Foca A, Abrial P, Salvetti A, Rivoire M, Lotteau V, Durantel D, André P, Ramière C.
Hepatol Commun. 2023 Apr 14;7(5):e0078.

An inventory of adjuvants used for vaccination in horses: the past, the present and the future.

Carnet F, Perrin-Cocon L, Paillot R, Lotteau V, Pronost S, Vidalain PO.
Vet Res. 2023 Mar 2;54(1):18. doi: 10.1186/s13567-023-01151-3.

What role for cellular metabolism in the control of hepatitis viruses?

Olivier Diaz, Pierre-Olivier Vidalain, Christophe Ramière, Vincent Lotteau and Laure Perrin-Cocon
Front. Immunol. 13:1033314. doi: 10.3389/fimmu.2022.1033314

Targeting the liver X receptor with dendrogenin A differentiates tumour cells to secrete immunogenic exosome-enriched vesicles.

Michel Record, Mehdi Attia, Kevin Carayon, Laly Pucheu, Julio Bunay, Régis Soulès, Silia Ayadi, Bruno Payré, Laure Perrin-Cocon, Florence Bourgailh, Antonin Lamazière, Vincent Lotteau, Marc Poirot, Sandrine Silvente-Poirot, Philippe de Medina.
Journal of Extracellular Vesicles, Volume 11 (4), April 2022, e12211. https://doi.org/10.1002/jev2.12211

Domain 2 of Hepatitis C Virus Protein NS5A activates glucokinase and induces lipogenesis in hepatocytes

Laure Perrin-Cocon, Cindy Kundlacz, Clémence Jacquemin, Xavier Hanoulle, Anne Aublin-Gex, Marianne Figl, Jeremy Manteca, Patrice André, Pierre-Olivier Vidalain, Vincent Lotteau, Olivier Diaz
Int. J. Mol. Sci. 2022, 23(2), 919; https://doi.org/10.3390/ijms23020919

A Bioluminescent 3CLPro Activity Assay to Monitor SARS-CoV-2 Replication and Identify Inhibitors

Cyrille Mathieu, Franck Touret, Clémence Jacquemin, Yves L. Janin, Antoine Nougairède, Manon Brailly, Magalie Mazelier, Didier Décimo, Virginie Vasseur, Aymeric Hans, José-Carlos Valle-Casuso, Xavier de Lamballerie, Branka Horvat, Patrice André, Mustapha Si-Tahar, Vincent Lotteau and Pierre-Olivier Vidalain.

Viruses 2021, 13, 1814. https://doi.org/10.3390/v13091814

The current landscape of coronavirus-host protein-protein interactions.
Perrin-Cocon L, Diaz O, Jacquemin C, Barthel V, Ogire E, Ramière C, André P, Lotteau V, Vidalain PO.J Transl Med. 2020 Aug 18;18(1):319. doi: 10.1186/s12967-020-02480-z.
 

Farnesoid X receptor-α is a proviral host factor for hepatitis B virus that is inhibited by ligands in vitro and in vivo.

Mouzannar K, Fusil F, Lacombe B, Ollivier A, Ménard C, Lotteau V, Cosset FL, Ramière C, André P.
FASEB J. 2019 Feb;33(2):2472-2483. doi: 10.1096/fj.201801181R.

Toll-like Receptor 4-Induced Glycolytic Burst in Human Monocyte-Derived Dendritic Cells Results from p38-Dependent Stabilization of HIF-1α and Increased Hexokinase II Expression.
Perrin-Cocon L, Aublin-Gex A, Diaz O, Ramière C, Peri F, André P, Lotteau V.
J Immunol. 2018 Sep 1;201(5):1510-1521. doi: 10.4049/jimmunol.1701522.

Influenza virus protein PB1-F2 interacts with CALCOCO2 (NDP52) to modulate innate immune response.
Leymarie O, Meyer L, Tafforeau L, Lotteau V, Costa BD, Delmas B, Chevalier C, Le Goffic R.
J Gen Virol. 2017 Jun;98(6):1196-1208. doi: 10.1099/jgv.0.000782.

Epstein-Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle.
Deschamps T, Bazot Q, Leske DM, MacLeod R, Mompelat D, Tafforeau L, Lotteau V, Maréchal V, Baillie GS, Gruffat H, Wilson JB, Manet E.
J Gen Virol. 2017 Feb;98(2):251-265. doi: 10.1099/jgv.0.000681.

TLR4 antagonist FP7 inhibits LPS-induced cytokine production and glycolytic reprogramming in dendritic cells, and protects mice from lethal influenza infection.
Perrin-Cocon L, Aublin-Gex A, Sestito SE, Shirey KA, Patel MC, André P, Blanco JC, Vogel SN, Peri F, Lotteau V.
Sci Rep. 2017 Jan 20;7:40791. doi: 10.1038/srep40791.

Nucleolin interacts with influenza A nucleoprotein and contributes to viral ribonucleoprotein complexes nuclear trafficking and efficient influenza viral replication.
Terrier O, Carron C, De Chassey B, Dubois J, Traversier A, Julien T, Cartet G, Proust A, Hacot S, Ressnikoff D, Lotteau V, Lina B, Diaz JJ, Moules V, Rosa-Calatrava M.
Sci Rep. 2016 Jul 4;6:29006. doi: 10.1038/srep29006.

Reciprocal regulation of farnesoid X receptor α activity and hepatitis B virus replication in differentiated HepaRG cells and primary human hepatocytes.
Radreau P, Porcherot M, Ramière C, Mouzannar K, Lotteau V, André P.
FASEB J. 2016 Sep;30(9):3146-54. doi: 10.1096/fj.201500134.

Cytostatic Effect of Repeated Exposure to Simvastatin: A Mechanism for Chronic Myotoxicity Revealed by the Use of Mesodermal Progenitors Derived from Human Pluripotent Stem Cells.
Peric D, Barragan I, Giraud-Triboult K, Egesipe AL, Meyniel-Schicklin L, Cousin C, Lotteau V, Petit V, Touhami J, Battini JL, Sitbon M, Pinset C, Ingelman-Sundberg M, Laustriat D, Peschanski M.
Stem Cells. 2015 Oct;33(10):2936-48. doi: 10.1002/stem.2107.

Early Steps of Jaagsiekte Sheep Retrovirus-Mediated Cell Transformation Involve the Interaction between Env and the RALBP1 Cellular Protein.
Monot M, Erny A, Gineys B, Desloire S, Dolmazon C, Aublin-Gex A, Lotteau V, Archer F, Leroux C.
J Virol. 2015 Aug;89(16):8462-73. doi: 10.1128/JVI.00590-15.

Control of temporal activation of hepatitis C virus-induced interferon response by domain 2 of nonstructural protein 5A.
Hiet MS, Bauhofer O, Zayas M, Roth H, Tanaka Y, Schirmacher P, Willemsen J, Grünvogel O, Bender S, Binder M, Lohmann V, Lotteau V, Ruggieri A, Bartenschlager R.
J Hepatol. 2015 Oct;63(4):829-37. doi: 10.1016/j.jhep.2015.04.015.

Virus-host interactomics: new insights and opportunities for antiviral drug discovery.
de Chassey B, Meyniel-Schicklin L, Vonderscher J, André P, Lotteau V.
Genome Med. 2014 Nov 29;6(11):115. doi: 10.1186/s13073-014-0115-1. eCollection 2014.

Epstein-Barr virus nuclear antigen 3A protein regulates CDKN2B transcription via interaction with MIZ-1.
Bazot Q, Deschamps T, Tafforeau L, Siouda M, Leblanc P, Harth-Hertle ML, Rabourdin-Combe C, Lotteau V, Kempkes B, Tommasino M, Gruffat H, Manet E.
Nucleic Acids Res. 2014 Sep;42(15):9700-16. doi: 10.1093/nar/gku697.

Specific polyclonal F(ab’)2 neutralize a large panel of highly pathogenic avian influenza A viruses (H5N1) and control infection in mice.
Herbreteau CH, Jacquot F, Rith S, Vacher L, Nguyen L, Carbonnelle C, Lotteau V, Jolivet M, Raoul H, Buchy P, Saluzzo JF.
Immunotherapy. 2014;6(6):699-708. doi: 10.2217/imt.14.40.

Marburgvirus hijacks nrf2-dependent pathway by targeting nrf2-negative regulator keap1.
Page A, Volchkova VA, Reid SP, Mateo M, Bagnaud-Baule A, Nemirov K, Shurtleff AC, Lawrence P, Reynard O, Ottmann M, Lotteau V, Biswal SS, Thimmulappa RK, Bavari S, Volchkov VE.
Cell Rep. 2014 Mar 27;6(6):1026-1036. doi: 10.1016/j.celrep.2014.02.027.

The metabolic sensors FXRα, PGC-1α, and SIRT1 cooperatively regulate hepatitis B virus transcription.
Curtil C, Enache LS, Radreau P, Dron AG, Scholtès C, Deloire A, Roche D, Lotteau V, André P, Ramière C.
FASEB J. 2014 Mar;28(3):1454-63. doi: 10.1096/fj.13-236372.

Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches.
Germain MA, Chatel-Chaix L, Gagné B, Bonneil É, Thibault P, Pradezynski F, de Chassey B, Meyniel-Schicklin L, Lotteau V, Baril M, Lamarre D.
Mol Cell Proteomics. 2014 Jan;13(1):184-203. doi: 10.1074/mcp.M113.030155.

Structure homology and interaction redundancy for discovering virus-host protein interactions.
de Chassey B, Meyniel-Schicklin L, Aublin-Gex A, Navratil V, Chantier T, André P, Lotteau V.
EMBO Rep. 2013 Oct;14(10):938-44. doi: 10.1038/embor.2013.130.

Activity of Hexokinase Is Increased by Its Interaction with Hepatitis C Virus Protein NS5A.
Ramière C, Rodriguez J, Enache LS, Lotteau V, André P, Diaz O. J Virol. 2014 Mar;88(6):3246-54. doi: 10.1128/JVI.02862-13.

Extended interaction network of procollagen C-proteinase enhancer-1 in the extracellular matrix.
Salza R, Peysselon F, Chautard E, Faye C, Moschcovich L, Weiss T, Perrin-Cocon L, Lotteau V, Kessler E, Ricard-Blum S. Biochem J. 2014 Jan 1;457(1):137-49. doi: 10.1042/BJ20130295.

HCV core-mediated activation of latent TGF-β via thrombospondin drives the crosstalk between hepatocytes and stromal environment.
Benzoubir N, Lejamtel C, Battaglia S, Testoni B, Benassi B, Gondeau C, Perrin-Cocon L, Desterke C, Thiers V, Samuel D, Levrero M, Bréchot C, Bourgeade MF. J Hepatol. 2013 Dec;59(6):1160-8. doi: 10.1016/j.jhep.2013.07.036.

The Interactomes of Influenza Virus NS1 and NS2 Proteins Identify New Host Factors and Provide Insights for ADAR1 Playing a Supportive Role in Virus Replication.
B. de Chassey, A. Aublin-Gex, A. Ruggieri, L. Meyniel-Schicklin, F. Pradezynski, N. Davoust, T. Chantier, L. Tafforeau, P.E. Mangeot, C. Ciancia, L. Perrin-Cocon, R. Bartenschlager, P. André, V. Lotteau. PLoS Pathog 2013;9(7): e1003440. doi:10.1371/journal.ppat.1003440

Hepatitis C virus/human interactome identifies SMURF2 and the viral protease as critical elements for the control of TGF-β signaling.
Verga-Gérard A, Porcherot M, Meyniel-Schicklin L, André P, Lotteau V, Perrin-Cocon L.
FASEB J. 2013 Oct;27(10):4027-40. doi: 10.1096/fj.13-229187.

New horizons for antiviral drug discovery from virus-host protein interaction networks.
de Chassey B, Meyniel-Schicklin L, Aublin-Gex A, André P, Lotteau V.
Curr Opin Virol. 2012 Oct;2(5):606-13. doi: 10.1016/j.coviro.2012.09.001.

Modified lipoproteins provide lipids that modulate dendritic cell immune function.
Perrin-Cocon L, Diaz O, André P, Lotteau V.
Biochimie. 2013 Jan;95(1):103-8. doi: 10.1016/j.biochi.2012.08.006.

Human group X secreted phospholipase A2 induces dendritic cell maturation through lipoprotein-dependent and -independent mechanisms.
Atout R, Karabina SA, Dollet S, Carreras M, Payré C, André P, Lambeau G, Lotteau V, Ninio E, Perrin-Cocon L.
Atherosclerosis. 2012 Jun;222(2):367-74. doi: 10.1016/j.atherosclerosis.2012.03.014.

Viruses and interactomes in translation.
Meyniel-Schicklin L, de Chassey B, André P, Lotteau V.
Mol Cell Proteomics. 2012 Jul;11(7):M111.014738. doi: 10.1074/mcp.M111.014738.

Genetic screens for the control of influenza virus replication: from meta-analysis to drug discovery.
de Chassey B, Meyniel-Schicklin L, Aublin-Gex A, André P, Lotteau V.
Mol Biosyst. 2012 Apr;8(4):1297-303. doi: 10.1039/c2mb05416g.

Comparative analysis of virus-host interactomes with a mammalian high-throughput protein complementation assay based on Gaussia princeps luciferase.
Neveu G, Cassonnet P, Vidalain PO, Rolloy C, Mendoza J, Jones L, Tangy F, Muller M, Demeret C, Tafforeau L, Lotteau V, Rabourdin-Combe C, Travé G, Dricot A, Hill DE, Vidal M, Favre M, Jacob Y.
Methods. 2012 Dec;58(4):349-59. doi: 10.1016/j.ymeth.2012.07.029.

Large scale genotype comparison of human papillomavirus E2-host interaction networks provides new insights for e2 molecular functions.
Muller M, Jacob Y, Jones L, Weiss A, Brino L, Chantier T, Lotteau V, Favre M, Demeret C.
PLoS Pathog. 2012;8(6):e1002761. doi: 10.1371/journal.ppat.1002761.

Epstein-Barr virus protein EB2 stimulates cytoplasmic mRNA accumulation by counteracting the deleterious effects of SRp20 on viral mRNAs.
Juillard F, Bazot Q, Mure F, Tafforeau L, Macri C, Rabourdin-Combe C, Lotteau V, Manet E, Gruffat H.
Nucleic Acids Res. 2012 Aug;40(14):6834-49. doi: 10.1093/nar/gks319.

High plasma level of nucleocapsid-free envelope glycoprotein-positive lipoproteins in hepatitis C patients.
Scholtes C, Ramière C, Rainteau D, Perrin-Cocon L, Wolf C, Humbert L, Carreras M, Guironnet-Paquet A, Zoulim F, Bartenschlager R, Lotteau V, André P, Diaz O.
Hepatology. 2012 Jul;56(1):39-48. doi: 10.1002/hep.25628.

Virus-human cell interactomes.
Tafforeau L, Rabourdin-Combe C, Lotteau V.
Methods Mol Biol. 2012;812:103-20. doi: 10.1007/978-1-61779-455-1_6.

High-density lipoprotein phospholipids interfere with dendritic cell Th1 functional maturation.
Perrin-Cocon L, Diaz O, Carreras M, Dollet S, Guironnet-Paquet A, André P, Lotteau V.
Immunobiology. 2012 Jan;217(1):91-9. doi: 10.1016/j.imbio.2011.07.030.

IRGM is a common target of RNA viruses that subvert the autophagy network.
Grégoire IP, Richetta C, Meyniel-Schicklin L, Borel S, Pradezynski F, Diaz O, Deloire A, Azocar O, Baguet J, Le Breton M, Mangeot PE, Navratil V, Joubert PE, Flacher M, Vidalain PO, André P, Lotteau V, Biard-Piechaczyk M, Rabourdin-Combe C, Faure M.
PLoS Pathog. 2011 Dec;7(12):e1002422. doi: 10.1371/journal.ppat.1002422.

Benchmarking a luciferase complementation assay for detecting protein complexes.
Cassonnet P, Rolloy C, Neveu G, Vidalain PO, Chantier T, Pellet J, Jones L, Muller M, Demeret C, Gaud G, Vuillier F, Lotteau V, Tangy F, Favre M, Jacob Y.
Nat Methods. 2011 Nov 29;8(12):990-2. doi: 10.1038/nmeth.1773.

Assembly of infectious hepatitis C virus particles.
Bartenschlager R, Penin F, Lohmann V, André P.
Trends in microbiology. 2011. 19 (2), 95-103.

Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome.
Merz A, Long G, Hiet MS, Brügger B, Chlanda P, Andre P, Wieland F, Krijnse-Locker J, Bartenschlager R.
J. Biol. Chem. 2011. 286 (4), 3018-3032.

Flavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screen.
Le Breton M, Meyniel-Schicklin L, Deloire A, Coutard B, Canard B, de Lamballerie X, Andre P, Rabourdin-Combe C, Lotteau V, Davoust N.
BMC Microbiol. 2011 Oct 20;11:234. doi: 10.1186/1471-2180-11-234.

Generation and comprehensive analysis of an influenza virus polymerase cellular interaction network.
Tafforeau L, Chantier T, Pradezynski F, Pellet J, Mangeot PE, Vidalain PO, Andre P, Rabourdin-Combe C, Lotteau V.
J Virol. 2011 Dec;85(24):13010-8. doi: 10.1128/JVI.02651-10.

Protein transfer into human cells by VSV-G-induced nanovesicles.
Mangeot PE, Dollet S, Girard M, Ciancia C, Joly S, Peschanski M, Lotteau V.
Mol Ther. 2011 Sep;19(9):1656-66. doi: 10.1038/mt.2011.138.

Role of nuclear receptors in hepatitis B and C infections.
André P, Ramière C, Scholtes C, Curtil C, Lotteau V.
Clin Res Hepatol Gastroenterol. 2011 Mar;35(3):169-75. doi: 10.1016/j.clinre.2011.01.001.

When the human viral infectome and diseasome networks collide: towards a systems biology platform for the aetiology of human diseases.
Navratil V, de Chassey B, Combe CR, Lotteau V.
BMC Syst Biol. 2011 Jan 21;5:13. doi: 10.1186/1752-0509-5-13.

System-level comparison of protein-protein interactions between viruses and the human type I interferon system network.
Navratil V, de Chassey B, Meyniel L, Pradezynski F, André P, Rabourdin-Combe C, Lotteau V.
J Proteome Res. 2010 Jul 2;9(7):3527-36. doi: 10.1021/pr100326j.

Morphological characterization and fusion properties of triglyceride-rich lipoproteins obtained from cells transduced with hepatitis C virus glycoproteins.
Pécheur EI, Diaz O, Molle J, Icard V, Bonnafous P, Lambert O, André P.
J. Biol. Chem. 2010. 285 (33), 25802-25811.

Single lysophosphatidylcholine components exhibit adjuvant activities in vitro and in vivo.
Bach G, Perrin-Cocon L, Gerossier E, Guironnet-Paquet A, Lotteau V, Inchauspé G, Fournillier A.
Clin Vaccine Immunol. 2010 Mar;17(3):429-38. doi: 10.1128/CVI.00420-09.

ViralORFeome: an integrated database to generate a versatile collection of viral ORFs.
Pellet J, Tafforeau L, Lucas-Hourani M, Navratil V, Meyniel L, Achaz G, Guironnet-Paquet A, Aublin-Gex A, Caignard G, Cassonnet P, Chaboud A, Chantier T, Deloire A, Demeret C, Le Breton M, Neveu G, Jacotot L, Vaglio P, Delmotte S, Gautier C, Combet C, Deleage G, Favre M, Tangy F, Jacob Y, Andre P, Lotteau V, Rabourdin-Combe C, Vidalain PO.
Nucleic Acids Res. 2010 Jan;38(Database issue):D371-8. doi: 10.1093/nar/gkp1000.

pISTil: a pipeline for yeast two-hybrid Interaction Sequence Tags identification and analysis.
Pellet J, Meyniel L, Vidalain PO, de Chassey B, Tafforeau L, Lotteau V, Rabourdin-Combe C, Navratil V.
BMC Res Notes. 2009 Oct 29;2:220. doi: 10.1186/1756-0500-2-220.

Secretion of hepatitis C virus envelope glycoproteins depends on assembly of apolipoprotein B positive lipoproteins.
Icard V, Diaz O, Scholtes C, Perrin-Cocon L, Ramière C, Bartenschlager R, Penin F, Lotteau V, André P.
PLoS One. 2009;4(1):e4233. doi: 10.1371/journal.pone.0004233.

Hepatitis C virus infection protein network.
de Chassey B, Navratil V, Tafforeau L, Hiet MS, Aublin-Gex A, Agaugué S, Meiffren G, Pradezynski F, Faria BF, Chantier T, Le Breton M, Pellet J, Davoust N, Mangeot PE, Chaboud A, Penin F, Jacob Y, Vidalain PO, Vidal M, André P, Rabourdin-Combe C, Lotteau V.
Mol Syst Biol. 2008;4:230. doi: 10.1038/msb.2008.66.

VirHostNet: a knowledge base for the management and the analysis of proteome-wide virus-host interaction networks.
Navratil V, de Chassey B, Meyniel L, Delmotte S, Gautier C, André P, Lotteau V, Rabourdin-Combe C.
Nucleic Acids Res. 2009 Jan;37(Database issue):D661-8. doi: 10.1093/nar/gkn794.

Transactivation of the hepatitis B virus core promoter by the nuclear receptor FXRalpha.
Ramière C, Scholtès C, Diaz O, Icard V, Perrin-Cocon L, Trabaud MA, Lotteau V, André P.
J Virol. 2008 Nov;82(21):10832-40. doi: 10.1128/JVI.00883-08.

Th1 disabled function in response to TLR4 stimulation of monocyte-derived DC from patients chronically-infected by hepatitis C virus.
Perrin-Cocon L, Agaugué S, Diaz O, Vanbervliet B, Dollet S, Guironnet-Paquet A, André P, Lotteau V.
PLoS One. 2008 May 28;3(5):e2260. doi: 10.1371/journal.pone.0002260.

Hepatitis C virus assembly: when fat makes it easier.
André P, Lotteau V.
J Hepatol. 2008 Jul;49(1):153-5. doi: 10.1016/j.jhep.2008.04.005.

Transmission of low-density hepatitis C viral particles during sexually transmitted acute resolving infection.
Diaz O, Cubero M, Trabaud MA, Quer J, Icard V, Esteban JI, Lotteau V, André P.
J Med Virol. 2008 Feb;80(2):242-6.

Enhancement of genotype 1 hepatitis C virus replication by bile acids through FXR.
Scholtes C, Diaz O, Icard V, Kaul A, Bartenschlager R, Lotteau V, André P.
J Hepatol. 2008 Feb;48(2):192-9.