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You are here: Home / Teams / Doublet P/Jarraud S - LegioPath / Publications


Selected publications since 2015 (group members are underlined)


Type I and Type IV Secretion in L. pneumophila

Deciphering Legionella effector delivery by Icm/Dot secretion system reveals a new role for c-diGMP signaling. Allombert J, Jaboulay C, Michard C, Andréa C, Charpentier X, Vianney A, Doublet PJ Mol Biol. 2021 Apr 9:166985. doi: 10.1016/j.jmb.2021.166985. Online ahead of print.PMID: 33845084


Regulatory Networks of the T4SS Control: From Host Cell Sensing to the Biogenesis and the Activity during the Infection. Jaboulay C, Godeux AS, Doublet P, Vianney AJ Mol Biol. 2021 Apr 30;433(9):166892. doi: 10.1016/j.jmb.2021.166892. Epub 2021 Feb 23.PMID: 33636165 Review.


More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells. Gomez-Valero L, Rusniok C, Carson D, Mondino S, Pérez-Cobas AE, Rolando M, Pasricha S, Reuter S, Demirtas J, Crumbach J, Descorps-Declere S, Hartland EL, Jarraud S, Dougan G, Schroeder GN, Frankel G, Buchrieser CProc Natl Acad Sci U S A. 2019 Feb 5;116(6):2265-2273. doi: 10.1073/pnas.1808016116. Epub 2019 Jan 18.PMID: 30659146 


The Legionella Kinase LegK2 Targets the ARP2/3 Complex To Inhibit Actin Nucleation on Phagosomes and Allow Bacterial Evasion of the Late Endocytic Pathway. Michard C, Sperandio D, Baïlo N, Pizarro-Cerdá J, LeClaire L, Chadeau-Argaud E, Pombo-Grégoire I, Hervet E, Vianney A, Gilbert C, Faure M, Cossart P, Doublet P. mBio. 2015 May 5;6(3):e00354-15. doi: 10.1128/mBio.00354-15.PMID: 25944859 


The structure of Legionella pneumophila LegK4 type four secretion system (T4SS) effector reveals a novel dimeric eukaryotic-like kinase. Flayhan A, Bergé C, Baïlo NDoublet P, Bayliss R, Terradot L. Sci Rep. 2015 Sep 30;5:14602. doi: 10.1038/srep14602.PMID: 26419332 


Functional type 1 secretion system involved in Legionella pneumophila virulence. Fuche F, Vianney A, Andrea C, Doublet P, Gilbert C. J Bacteriol. 2015 Feb;197(3):563-71. doi: 10.1128/JB.02164-14. Epub 2014 Nov 24.PMID: 25422301 


Legionellosis treatment failure and antibiotic resistance

Legionella antibiotic susceptibility testing: is it time for international standardization and evidence-based guidance? Portal E, Descours G, Ginevra C, Mentasti M, Afshar B, Chand M, Day J, Echahidi F, Franzin L, Gaia V, Lück C, Meghraoui A, Moran-Gilad J, Ricci ML, Lina G, Uldum S, Winchell J, Howe R, Bernard K, Spiller OB, Chalker VJ, Jarraud S; ESCMID Study Group for Legionella Infections (ESGLI). J Antimicrob Chemother. 2021 Apr 13;76(5):1113-1116. doi: 10.1093/jac/dkab027.PMID: 33608737

Persistent Legionnaires' Disease and Associated Antibiotic Treatment Engender a Highly Disturbed Pulmonary Microbiome Enriched in Opportunistic Microorganisms. Pérez-Cobas AE, Ginevra C, Rusniok C, Jarraud S, Buchrieser C. mBio. 2020 May 19;11(3):e00889-20. doi: 10.1128/mBio.00889-20.PMID: 32430469 


Slowly or Nonresolving Legionnaires' Disease: Case Series and Literature Review. Pouderoux C, Ginevra C, Descours G, Ranc AG, Beraud L, Boisset S, Magand N, Conrad A, Bergeron-Lafaurie A, Jarraud S, Ader FClin Infect Dis. 2020 Apr 15;70(9):1933-1940. doi: 10.1093/cid/ciz538.PMID: 31242293


KKL-35 Exhibits Potent Antibiotic Activity against Legionella Species Independently of trans-Translation Inhibition. Brunel R, Descours G, Durieux I, Doublet P, Jarraud S, Charpentier X. Antimicrob Agents Chemother. 2018 Jan 25;62(2):e01459-17. doi: 10.1128/AAC.01459-17. Print 2018 Feb.PMID: 29158279


Macrolide resistance in Legionella pneumophila: the role of LpeAB efflux pump. Massip C, Descours G, Ginevra C, Doublet P, Jarraud S, Gilbert CJ Antimicrob Chemother. 2017 May 1;72(5):1327-1333. doi: 10.1093/jac/dkw594.PMID: 28137939


Ribosomal Mutations Conferring Macrolide Resistance in Legionella pneumophila. Descours G, Ginevra C, Jacotin N, Forey F, Chastang J, Kay E, Etienne J, Lina G, Doublet P, Jarraud SAntimicrob Agents Chemother. 2017 Feb 23;61(3):e02188-16. doi: 10.1128/AAC.02188-16. Print 2017 Mar.PMID: 28069647


Minimum inhibitory concentration (MIC) distribution among wild-type strains of Legionella pneumophila identifies a subpopulation with reduced susceptibility to macrolides owing to efflux pump genes. Vandewalle-Capo M, Massip C, Descours G, Charavit J, Chastang J, Billy PA, Boisset S, Lina G, Gilbert C, Maurin M, Jarraud S, Ginevra CInt J Antimicrob Agents. 2017 Nov;50(5):684-689. doi: 10.1016/j.ijantimicag.2017.08.001. Epub 2017 Aug 4.PMID: 28782709


Digital PCR for Detection and Quantification of Fluoroquinolone Resistance in Legionella pneumophila. Hennebique A, Bidart M, Jarraud S, Beraud L, Schwebel C, Maurin M, Boisset S. Antimicrob Agents Chemother. 2017 Aug 24;61(9):e00628-17. doi: 10.1128/AAC.00628-17. Print 2017 Sep.PMID: 28674045 


Hidden Selection of Bacterial Resistance to Fluoroquinolones In Vivo: The Case of Legionella pneumophila and Humans. Shadoud L, Almahmoud I, Jarraud S, Etienne J, Larrat S, Schwebel C, Timsit JF, Schneider D, Maurin M. EBioMedicine. 2015 Jul 17;2(9):1179-85. doi: 10.1016/j.ebiom.2015.07.018. eCollection 2015 Sep.PMID: 26501115


Epidemiology and clinical microbiology of legionellosis 

TNF-α response in macrophages depends on clinical Legionella pneumophila isolates genotypes. Guillemot J, Ginevra C, Allam C, Kay E, Gilbert CDoublet P, Jarraud S, Chapalain AVirulence. 2022 Dec;13(1):160-173. doi: 10.1080/21505594.2021.2022861.


A real-time PCR for specific detection of the Legionella pneumophila serogroup 1 ST1 complex. Ginevra C, Chastang J, David S, Mentasti M, Yakunin E, Chalker VJ, Chalifa-Caspi V, Valinsky L, Jarraud S, Moran-Gilad J; ESCMID Study Group for Legionella Infections (ESGLI). Clin Microbiol Infect. 2020 Apr;26(4):514.e1-514.e6. doi: 10.1016/j.cmi.2019.09.002. Epub 2019 Sep 13.PMID: 31525518


Transmission of Legionnaires'' Disease through Toilet Flushing. Couturier J, Ginevra C, Nesa D, Adam M, Gouot C, Descours G, Campèse C, Battipaglia G, Brissot E, Beraud L, Ranc AG, Jarraud S, Barbut F. Emerg Infect Dis. 2020 Jul;26(7):1526-1528. PMID: 32568063


The clinical presentation of Legionella arthritis reveals the mode of infection and the bacterial species: case report and literature review. Ibranosyan M, Beraud L, Lemaire H, Ranc AG, Ginevra C, Jarraud S, Descours GBMC Infect Dis. 2019 Oct 21;19(1):864. doi: 10.1186/s12879-019-4488-z.PMID: 31638905


Seeding and Establishment of Legionella pneumophila in Hospitals: Implications for Genomic Investigations of Nosocomial Legionnaires' Disease. David S, Afshar B, Mentasti M, Ginevra C, Podglajen I, Harris SR, Chalker VJ, Jarraud S, Harrison TG, Parkhill J. Clin Infect Dis. 2017 May 1;64(9):1251-1259. doi: 10.1093/cid/cix153.PMID: 28203790

Legionnaires' disease in Europe, 2011 to 2015. Beauté J; Jarraud S. The European Legionnaires' Disease Surveillance Network. Euro Surveill. 2017 Jul 6;22(27):30566. doi: 10.2807/1560-7917.ES.2017.22.27.30566.PMID: 28703097 


Rapid detection and evolutionary analysis of Legionella pneumophila serogroup 1 sequence type 47. Mentasti M, Cassier P, David S, Ginevra C, Gomez-Valero L, Underwood A, Afshar B, Etienne J, Parkhill J, Chalker V, Buchrieser C, Harrison TG, Jarraud S; ESCMID Study Group for Legionella Infections (ESGLI). Clin Microbiol Infect. 2017 Apr;23(4):264.e1-264.e9. doi: 10.1016/j.cmi.2016.11.019. Epub 2016 Nov 30.PMID: 27915212 


Multiple major disease-associated clones of Legionella pneumophila have emerged recently and independently. David S, Rusniok C, Mentasti M, Gomez-Valero L, Harris SR, Lechat P, Lees J, Ginevra C, Glaser P, Ma L, Bouchier C, Underwood A, Jarraud S, Harrison TG, Parkhill J, Buchrieser C. Genome Res. 2016 Nov;26(11):1555-1564. doi: 10.1101/gr.209536.116. Epub 2016 Sep 23.PMID: 27662900 


Molecular epidemiology, phylogeny and evolution of Legionella. Khodr A, Kay E, Gomez-Valero L, Ginevra C, Doublet P, Buchrieser C, Jarraud SInfect Genet Evol. 2016 Sep;43:108-22. doi: 10.1016/j.meegid.2016.04.033. Epub 2016 May 13.PMID: 27180896 


publication related to SarS-Cov2 infection and  severity of COVID-19

COVID-19 diagnosis HCL consortium1. Co-infection with Legionella and SARS-CoV-2, France, March 2020. Allam C, Gaymard A, Descours G, Ginevra C, Josset L, Bouscambert M, Beraud L, Ibranosyan M, Golfier C, Friggeri A, Lina B, Campèse C, Ader F, Jarraud SEmerg Infect Dis. 2021 Sep 1;27(11). doi: 10.3201/eid2711.202150. Epub ahead of print. PMID: 34469708.


DisCoVeRy Study Group. Remdesivir plus Standard of Care versus Standard of Care Alone for the Treatment of Patients Admitted to Hospital with COVID-19 (DisCoVeRy): A Phase 3, Randomised, Controlled, Open-Label Trial. Ader, F.; Bouscambert-Duchamp, M.; Hites, M.; Peiffer-Smadja, N.; Poissy, J.; Belhadi, D.; Diallo, A.; Lê, M.-P.; Peytavin, G.; Staub, T.; Greil, R.; Guedj, J.; Paiva, J.-A.; Costagliola, D.; Yazdanpanah, Y.; Burdet, C.; Mentré, F. Lancet Infect. Dis. 2021, Sep 1473-3099(21)00485-0.