Publications
ALL OUR PUBLICATIONS ARE ON PUBMED
Selected publications since 2017 (group members are underlined)
EFFECTORS and Type IV Secretion in L. pneumophila
Dual Control of Host Actin Polymerization by a Legionella Effector Pair. M. Pillon, C. Michard, N. Baïlo, J. Bougnon, K. Picq, O. Dubois, C. Andrea, L. Attaiech, V. Daubin, S. Jarraud, E. Kay, P. Doublet. Cell. Microbiol. 2024 vol. 2024 ID 8896219 https://doi.org/10.1155/2024/8896219
Deciphering Legionella effector delivery by Icm/Dot secretion system reveals a new role for c-diGMP signaling. Allombert J, Jaboulay C, Michard C, Andréa C, Charpentier X, Vianney A, Doublet P. J Mol Biol. 2021 Apr 9:166985. doi: 10.1016/j.jmb.2021.166985.PMID: 33845084
Regulatory Networks of the T4SS Control: From Host Cell Sensing to the Biogenesis and the Activity during the Infection. Jaboulay C, Godeux AS, Doublet P, Vianney A. J Mol Biol. 2021 Apr 30;433(9):166892. doi: 10.1016/j.jmb.2021.166892. Epub 2021 Feb 23.PMID: 33636165 Review.
More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells. Gomez-Valero L, Rusniok C, Carson D, Mondino S, Pérez-Cobas AE, Rolando M, Pasricha S, Reuter S, Demirtas J, Crumbach J, Descorps-Declere S, Hartland EL, Jarraud S, Dougan G, Schroeder GN, Frankel G, Buchrieser C. Proc Natl Acad Sci USA. 2019 Feb 5;116(6):2265-2273. doi: 10.1073/pnas.1808016116. Epub 2019 Jan 18.PMID: 30659146
The Legionella Kinase LegK2 Targets the ARP2/3 Complex To Inhibit Actin Nucleation on Phagosomes and Allow Bacterial Evasion of the Late Endocytic Pathway. Michard C, Sperandio D, Baïlo N, Pizarro-Cerdá J, LeClaire L, Chadeau-Argaud E, Pombo-Grégoire I, Hervet E, Vianney A, Gilbert C, Faure M, Cossart P, Doublet P. mBio. 2015 May 5;6(3):e00354-15. doi: 10.1128/mBio.00354-15.PMID: 25944859
Legionellosis treatment failure and antibiotic resistance
Bacterial persistence in Legionella pneumophila clinical isolates from patients with recurring legionellosis. Adams-Ward X, Chapalain A, Ginevra C, Jarraud S, Doublet P, Gilbert C. Front Cell Infect Microbiol. 2023 Aug 1;13:1219233. doi: 10.3389/fcimb.2023.1219233. eCollection 2023. PMID: 37600942
Intracellular persister: A stealth agent recalcitrant to antibiotics. Personnic N, Doublet P, Jarraud S. Front Cell Infect Microbiol. 2023 Mar 31;13:1141868. doi: 10.3389/fcimb.2023.1141868. eCollection 2023. PMID: 37065203
Detection of highly macrolide-resistant Legionella pneumophila strains from a hotel water network using systematic whole-genome sequencing. Ginevra C, Beraud L, Pionnier I, Sallabery K, Bentayeb H, Simon B, Allam C, Chastang J, Ibranosyan M, Decroix V, Campese C, Jarraud S, Descours G. J Antimicrob Chemother. 2022 Jul 28;77(8):2167-2170. doi: 10.1093/jac/dkac173. PMID: 35678276
Legionella antibiotic susceptibility testing: is it time for international standardization and evidence-based guidance? Portal E, Descours G, Ginevra C, Mentasti M, Afshar B, Chand M, Day J, Echahidi F, Franzin L, Gaia V, Lück C, Meghraoui A, Moran-Gilad J, Ricci ML, Lina G, Uldum S, Winchell J, Howe R, Bernard K, Spiller OB, Chalker VJ, Jarraud S; ESCMID Study Group for Legionella Infections (ESGLI). J Antimicrob Chemother. 2021 Apr 13;76(5):1113-1116. doi: 10.1093/jac/dkab027.PMID: 33608737
Persistent Legionnaires' Disease and Associated Antibiotic Treatment Engender a Highly Disturbed Pulmonary Microbiome Enriched in Opportunistic Microorganisms. Pérez-Cobas AE, Ginevra C, Rusniok C, Jarraud S, Buchrieser C. mBio. 2020 May 19;11(3):e00889-20. doi: 10.1128/mBio.00889-20.PMID: 32430469
Slowly or Nonresolving Legionnaires' Disease: Case Series and Literature Review. Pouderoux C, Ginevra C, Descours G, Ranc AG, Beraud L, Boisset S, Magand N, Conrad A, Bergeron-Lafaurie A, Jarraud S, Ader F. Clin Infect Dis. 2020 Apr 15;70(9):1933-1940. doi: 10.1093/cid/ciz538.PMID: 31242293
KKL-35 Exhibits Potent Antibiotic Activity against Legionella Species Independently of trans-Translation Inhibition. Brunel R, Descours G, Durieux I, Doublet P, Jarraud S, Charpentier X. Antimicrob Agents Chemother. 2018 Jan 25;62(2):e01459-17. doi: 10.1128/AAC.01459-17.PMID: 29158279
Macrolide resistance in Legionella pneumophila: the role of LpeAB efflux pump. Massip C, Descours G, Ginevra C, Doublet P, Jarraud S, Gilbert C. J Antimicrob Chemother. 2017 May 1;72(5):1327-1333. doi: 10.1093/jac/dkw594.PMID: 28137939
Ribosomal Mutations Conferring Macrolide Resistance in Legionella pneumophila. Descours G, Ginevra C, Jacotin N, Forey F, Chastang J, Kay E, Etienne J, Lina G, Doublet P, Jarraud S. Antimicrob Agents Chemother. 2017 Feb 23;61(3):e02188-16. doi: 10.1128/AAC.02188-16. Print 2017 Mar.PMID: 28069647
Minimum inhibitory concentration (MIC) distribution among wild-type strains of Legionella pneumophila identifies a subpopulation with reduced susceptibility to macrolides owing to efflux pump genes. Vandewalle-Capo M, Massip C, Descours G, Charavit J, Chastang J, Billy PA, Boisset S, Lina G, Gilbert C, Maurin M, Jarraud S, Ginevra C. Int J Antimicrob Agents. 2017 Nov;50(5):684-689. doi: 10.1016/j.ijantimicag.2017.08.001. Epub 2017 Aug 4.PMID: 28782709
Digital PCR for Detection and Quantification of Fluoroquinolone Resistance in Legionella pneumophila. Hennebique A, Bidart M, Jarraud S, Beraud L, Schwebel C, Maurin M, Boisset S. Antimicrob Agents Chemother. 2017 Aug 24;61(9):e00628-17. doi: 10.1128/AAC.00628-17. Print 2017 Sep.PMID: 28674045
SEVERITY of legionellosis
Hyper-inflammatory profile and immunoparalysis in patients with severe Legionnaires' disease. Allam C, Mouton W, Testaert H, Ginevra C, Fessy N, Ibranosyan M, Descours G, Beraud L, Guillemot J, Chapalain A, Albert-Vega C, Richard JC, Argaud L, Friggeri A, Labeye V, Jamilloux Y, Freymond N, Venet F, Lina G, Doublet P, Ader F, Trouillet-Assant S, Jarraud S. Front Cell Infect Microbiol. 2023 Oct 27;13:1252515. doi: 10.3389/fcimb.2023.1252515. eCollection 2023.
The respiratory tract microbiome, the pathogen load, and clinical interventions define severity of bacterial pneumonia Pérez-Cobas AE, Ginevra C, Rusniok C, Jarraud S, Buchrieser C. Cell Rep Med. 2023 Sep 19;4(9):101167. doi: 10.1016/j.xcrm.2023.101167. Epub 2023 Aug 25. PMID: 37633274
Hiding in the yolk: A unique feature of Legionella pneumophila infection of zebrafish. Viana F, Boucontet L, Laghi V, Schator D, Ibranosyan M, Jarraud S, Colucci-Guyon E, Buchrieser C. PLoS Pathog. 2023 May 8;19(5):e1011375. doi: 10.1371/journal.ppat.1011375. eCollection 2023 May. PMID: 37155695
TNF-α response in macrophages depends on clinical Legionella pneumophila isolates genotypes. Guillemot J, Ginevra C, Allam C, Kay E, Gilbert C, Doublet P, Jarraud S, Chapalain A. Virulence. 2022 Dec;13(1):160-173. doi: 10.1080/21505594.2021.2022861
Epidemiology and clinical microbiology of legionellosis
Rapid adaptations of Legionella pneumophila to the human host. Leenheer D, Moreno AB, Paranjape K, Murray S, Jarraud S, Ginevra C, Guy L. Microb Genom. 2023 Mar;9(3):mgen000958. doi: 10.1099/mgen.0.000958. PMID: 36947445
A real-time PCR for specific detection of the Legionella pneumophila serogroup 1 ST1 complex. Ginevra C, Chastang J, David S, Mentasti M, Yakunin E, Chalker VJ, Chalifa-Caspi V, Valinsky L, Jarraud S, Moran-Gilad J; ESCMID Study Group for Legionella Infections (ESGLI). Clin Microbiol Infect. 2020 Apr;26(4):514.e1-514.e6. doi: 10.1016/j.cmi.2019.09.002. Epub 2019 Sep 13.PMID: 31525518
Transmission of Legionnaires'' Disease through Toilet Flushing. Couturier J, Ginevra C, Nesa D, Adam M, Gouot C, Descours G, Campèse C, Battipaglia G, Brissot E, Beraud L, Ranc AG, Jarraud S, Barbut F. Emerg Infect Dis. 2020 Jul;26(7):1526-1528. PMID: 32568063
The clinical presentation of Legionella arthritis reveals the mode of infection and the bacterial species: case report and literature review. Ibranosyan M, Beraud L, Lemaire H, Ranc AG, Ginevra C, Jarraud S, Descours G. BMC Infect Dis. 2019 Oct 21;19(1):864. doi: 10.1186/s12879-019-4488-z.PMID: 31638905
Seeding and Establishment of Legionella pneumophila in Hospitals: Implications for Genomic Investigations of Nosocomial Legionnaires' Disease. David S, Afshar B, Mentasti M, Ginevra C, Podglajen I, Harris SR, Chalker VJ, Jarraud S, Harrison TG, Parkhill J. Clin Infect Dis. 2017 May 1;64(9):1251-1259. doi: 10.1093/cid/cix153.PMID: 28203790
Legionnaires' disease in Europe, 2011 to 2015. Beauté J; Jarraud S. The European Legionnaires' Disease Surveillance Network. Euro Surveill. 2017 Jul 6;22(27):30566. doi: 10.2807/1560-7917.ES.2017.22.27.30566.PMID: 28703097
publication related to SarS-Cov2 infection and severity of COVID-19
COVID-19 diagnosis HCL consortium1. Co-infection with Legionella and SARS-CoV-2, France, March 2020. Allam C, Gaymard A, Descours G, Ginevra C, Josset L, Bouscambert M, Beraud L, Ibranosyan M, Golfier C, Friggeri A, Lina B, Campèse C, Ader F, Jarraud S. Emerg Infect Dis. 2021 Sep 1;27(11). doi: 10.3201/eid2711.202150. Epub ahead of print. PMID: 34469708
DisCoVeRy Study Group. Remdesivir plus Standard of Care versus Standard of Care Alone for the Treatment of Patients Admitted to Hospital with COVID-19 (DisCoVeRy): A Phase 3, Randomised, Controlled, Open-Label Trial. Ader, F.; Bouscambert-Duchamp, M.; Hites, M.; Peiffer-Smadja, N.; Poissy, J.; Belhadi, D.; Diallo, A.; Lê, M.-P.; Peytavin, G.; Staub, T.; Greil, R.; Guedj, J.; Paiva, J.-A.; Costagliola, D.; Yazdanpanah, Y.; Burdet, C.; Mentré, F. Lancet Infect. Dis. 2021 Sep 1473-3099(21)00485-0. https://doi.org/10.1016/S1473-3099(21)00485-0