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You are here: Home / About us / Events / CIRI seminar: Pr. Michaël L. DUSTIN

CIRI seminar: Pr. Michaël L. DUSTIN

"Supramolecular assemblies in the immunological synapse"
When May 19, 2022
from 11:00 AM to 12:30 PM
Where Amphi Pasteur
Contact Name

Pr. Michaël L DUSTIN (Kennedy Institute of Rheumatology, University of Oxford - GB): "Supramolecular assemblies in the immunological synapse"

 

Abstract: In this talk I will provide a historical background on immunological synapses and then discuss three ongoing stories. We started our analysis of supramolecular assemblies in the immunological synapse through study of CD4 helper T cells- first looking at signaling through antigen receptors and then the fate of those receptors in extracellular vesicles created by T cell at the synaptic interface to coordinate immune responses.  We next adapted our technology to investigated how CD8 cytotoxic T cells and NK cells us supramolecular assemblies to kill infected and cancerous cells.  Which cytotoxic mechanisms are deployed is tactical and basic on what target-associated receptors are discovered by the T cell.  FAS on targets triggered extracellular vesicles with FasL to trigger target suicide, whereas 100 nm protein “bombs” with a core of cytotoxic perforin and granzymes and a shell of thrombospondin-1 were deployed when the target expressed ICAM1 or CD47.  We refer to these protein bombs as supramolecular attack particles and these have potential as novel therapeutics.  Finally, I will discuss how malaria parasites use some members of a large family of proteins called RIFINs to inhibit attack by innate natural killer (NK) cells-creating an inhibitory immunological synapse to protect parasitized red blood cells.  In order to defeat this mechanism, the host makes extraordinary antibodies that incorporate entire RIFIN targets into antibody V-regions.

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