Séminaire CIRI : Dr. Philippe AFONSO

Philippe AFONSO (Unité d’Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, Université de Paris, CNRS) : "Neuroinvasion by HTLV and ZIKV: how blood-borne viruses cross the blood brain barrier"

Abstract: The central nervous system (CNS) is naturally protected from blood-borne viruses by a series of selective interfaces, among which the blood-brain barrier (BBB). The BBB is the largest CNS/blood interface, composed primarily of a continuous endothelium sealed with tight junctions. Over the years, we have evidenced factors regulating the interaction between BBB endothelial cell and viruses (namely the retrovirus HTLV-1 and the flavivirus ZIKV), in order to understand the mechanisms of neuroinvasion.

Hôte: François-Loïc Cosset.