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MCU position in Immunology UCBL1/CIRI

Teaching in Basic Immunology, Immunopathology, Immunotherapy Research in Immunology in the context of Host-Pathogen Response/Inflammation

TEACHING:

The teacher-researcher will join the immunology teaching pedagogic team within the UCBL Biosciences UFR. The immunology teaching team currently consists of 6 teacher-researchers who teach immunology in the Bachelor's and Master's courses. The candidate will be involved in these courses, in particular in a Bachelor's course with a large number of students (Cell Biology and Immunology, approximately 500-550 students per year) and in specialised courses in the new Master 2 "Immunology, Immunopathology, Immunotherapy" (3i, courses in English) and the international Master's course "Leading International Vaccinology Education" (Live, also in English). He/she will integrate and develop theoretical and practical teaching in molecular and cellular immunology. Working with the entire teaching team, he/she will be expected to progressively take on teaching responsibilities and demonstrate innovation in teaching. Excellent knowledge of immunology and advanced knowledge of immunopathology and/or immunotherapy are expected, as well as a good command of French and English (around a quarter of the teaching) in order to contribute to the dynamism and influence of Université Claude Bernard Lyon 1's training courses, serving national and international students. International post- doctoral experience will be highly valued.

TEACHING CONTACT:

Aurore Rozières, MCF, responsable de l’équipe pédagogique d’Immunologie : aurore.rozieres@univ-lyon1.fr ; 04 37 28 23 77.

RESEARCH:

The recruited teacher-researcher will carry out their research activity on a topic related to the study of immunology in the context of host-pathogen interactions or in an inflammatory context. The candidate's research activity will be carried out either within the Centre International de Recherche en Infectiologie (CIRI, U1111, UMR5308), or within the Viral infections and comparative pathology laboratory (IVPC, UMR754). CIRI studies the mechanisms involved in the immune response against infectious agents and inflammatory diseases, while IVPC studies the immune responses induced by infection of zoonotic arboviruses or respiratory viruses.

The candidate will be expected to integrate and develop his/her research activity in one of the CIRI or IVPC teams proposed below. The choice of host team will be based on the candidate's research profile.

Concerning the CIRI, the candidate will join:

  • The ‘Autophagy Infection Immunity’ team (team APY, Pr M. Faure), which focuses on the regulation and role of autophagy in immunity in the context of infection and inflammation. The team is composed of teacher-researchers, researchers and clinician-researchers, and coordinates fundamental and translational research projects. It is within one of these frameworks that the candidate will be able to develop a project, in cellular, integrated and/or omic, human and/or mouse models, aimed at i/ detailing the molecular and/or cellular relationship of autophagy, or autophagic factors, in the intrinsic immune response of the cell against a pathogen (bacteria and/or virus) or, ii/ the role of autophagy, or of autophagic factors, in immunity in inflammatory bowel diseases (IBD).

Concerning IVPC, the candidate will have to join one of the following two teams:

  • The Biology of Bunyavirales team (BUNYA, Dr M. Ratinier) focuses on the virulence factors of zoonotic arboviruses, particularly on how these viruses modulate their pathogenicity in relation to viro-induced innate immunity pathways, and depending on the organs involved (liver vs. brain), the species infected (human vs. ruminant) and/or the route of infection (aerosol vs. mosquito bite).
  • The Cell Biology of Early Interactions between Viruses and the Host Cell team (iWAYS, Dr P.Y. Lozach, Dr C. Maisse) has two main lines of research: 1) on the mechanisms by which arboviruses enter host cells, particularly dendritic cells, and the molecular and cellular mechanisms of response to cellular stress (link between innate immune response and cell death) and 2) on the mechanisms of immune response induced by respiratory pathogens in complexe 2D and 3D lung complex models (organoid, ALI) (Dr F. Archer).

 

RESEARCH CONTACTS

CIRI : Mathias Faure, mathias.faure@inserm.fr (responsable équipe APY) ; Dimitri Lavillette, dimitri.lavillette@cnrs.fr (Directeur CIRI).

IVPC : Maxime Ratinier, maxime.ratinier@univ-lyon1.fr; Pierre-Yves Lozach, pierre-yves.lozach@univ-lyon1.fr; Carine Maisse, carine.paradisi@univ-lyon1.fr; Fabienne Archer, fabienne.archer@univ-lyon1.fr (Directrice IVPC).