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Interleukins 15 and 18 synergistically prime the antitumor function of natural killer cells through noncanonical activation of mTORC1
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Natural killer (NK) cells have antitumor activity that is primed by IL-15 and IL-18, components of a cytokine cocktail used in NK cell–based cancer immunotherapy. Fallone et al. found that IL-15 and IL-18 synergized to activate the complex mTORC1, which resulted in increased proliferation and function of both mouse and human NK cells. IL-15 and IL-18 stimulated mTORC1 activity through distinct pathways not previously implicated in its regulation. The combination of IL-15 and IL-18 improved the survival of mice engrafted with tumor cells, suggesting a therapeutic strategy to enhance the efficacy of NK cell–based cancer immunotherapy
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Walzer T - LYACTS
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Association of IFNAR1 and IFNAR2 with COVID-19 severity
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The Lancet Microbe: Yaugel-Novoa M., Bourlet T., Longet S., Botehlo-Nevers E, Paul S. https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(23)00095-2/fulltext
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Paul S - GIMAP
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Actualités
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Prior COVID-19 Immunization Does Not Cause IgA- or IgG-Dependent Enhancement of SARS-CoV-2 Infection
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Vaccines: Yaugel-Novoa M., Noailly B., Jospin F., Berger A.E., Waeckel L., Botelho-Nevers E., Longet S., Bourlet T., Paul S. https://www.mdpi.com/2076-393X/11/4/773
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Paul S - GIMAP
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An inventory of adjuvants used for vaccination in horses: the past, the present and the future.
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Carnet F, Perrin-Cocon L, Paillot R, Lotteau V, Pronost S, Vidalain PO.
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VIDALAIN PO - VIRIMI
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Alteration of microbiota antibody-mediated immune selection contributes to dysbiosis in Inflammatory Bowel Diseases
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Eva Michaud, Louis Waeckel, Rémi Gayet, Roman Goguyer-Deschaumes, Blandine Chanut, Fabienne Jospin, Katell Bathany, Magali Monnoye, Coraline Genet, Amelie Prier, Caroline Tokarski, Philippe Gérard, Xavier Roblin, Nicolas Rochereau, Stéphane Paul. Embo Molecular Medicine. https://www.embopress.org/doi/full/10.15252/emmm.202115386
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Paul S - GIMAP
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A neutralizing antibody prevents postfusion transition of measles virus fusion protein
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Zyla DS, Marca RD, Niemeyer G, Zipursky G, Stearns K, Leedale C, Callaway H, Sobolik E, Hariharan C, Parekh D, Avalos RD, Horvat B, Mathieu C, Greninger AL, Hastie KM, Niewiesk S, Moscona A, Porotto M, Saphire EO. Science
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Horvat B - IbIV
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mTOR Activation Underlies Enhanced B Cell Proliferation and Autoimmunity in PrkcdG510S/G510S Mice
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Moreews M ; Mathieu AL, Pouxvielh K... Marçais A, Walzer T, Belot A
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Walzer T - LYACTS
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Impaired mucosal IgA response in patients with severe COVID-19
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Yaugel-Novoa M, Noailly B, Jospin F, Pizzorno A, Traversier A, Pozzetto B, Waeckel L, Longet S, Pillet S, Botelho-Nevers E, Rosa-Calatrava M, Bourlet T, Paul S. Emerg Microbes Infect. 2024. doi:10.1080/22221751.2024.2401940
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Paul S - GIMAP
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Mucosal nirsevimab levels in respiratory syncytial virus breakthrough bronchiolitis
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Pillet S, Cantais A, Noailly B, Jospin F, Zekre F, Boussetta-Charfi O, Chenafi-Adham S, Bourlet T, Fourati S, Paul S. Lancet Infect Dis. 2024. doi:10.1016/S1473-3099(24)00600-5.
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Paul S - GIMAP
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Lipoprotein receptors: A little grease for enveloped viruses to open the lock?
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François-Loïc Cosset and Solène Denolly. JBC, 2024. DOI: 10.1016/j.jbc.2024.107849
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Cosset FL - EVIR
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