Personnic N - PERSIST

The PERSIST team investigates bacterial phenotypic heterogeneity—a conserved strategy whereby genetically identical bacteria transiently express distinct phenotypes to improve the performance of the entire population. We investigate the molecular bases of the pathogen variation, and how single-cell behavior shapes infection outcomes, and contributes to antibiotic treatment failure, particularly through the study of persisters—rare, non-replicating bacteria that evade antibiotics and drive relapse. Using inovative infection models as well as cutting-edge single-cell imaging and Omics-based approaches, we dissect pathogen behavior at unprecedented resolution. Our research spans key ESKAPE pathogens identified as critical by the WHO, providing both fundamental insights and translational value in the fight against antibiotic resistance.

The team PERSIST originates from the junior group led by Nicolas Personnic at the University of Zürich (Switzerland), sponsored by the Swiss National Foundation Ambizione program 

Our team is located in the third floor of the Rosalind Franklin building in the Gerland campus of Lyon.

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