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Projets

 
 
 

Our research program focuses on epidermal immunity. We will continue our efforts to decipher the mechanisms by which environmental antigens trigger innate epidermal immunity, thereby initiating or amplifying allergic and inflammatory processes through the activation and regulation of tissue-infiltrating lymphocytes (TILs), including tissue-resident memory T cells (TRMs).

The ultimate goal of our work is to help shift the care paradigm for our diseases of interest: (i) by proposing new diagnostic approaches based on molecular stratification to guide and personalize targeted therapies, thereby increasing their efficacy and reducing the risk of progression toward severe and/or refractory forms; (ii) by developing new therapies that not only suppress cutaneous symptoms but also prevent disease chronicity; and (iii) by proposing new preventive strategies through the characterization of the impact of outdoor pollution on the immunopathology of these diseases.

Four major projects are currently being carried out within the team (Figure 5).

 

 

 

Project 1 : Mechanisms of tissue-resident memory T cell (TRM) differentiation in cutaneous allergic diseases - Coordination:  Marc Vocanson

Project 1 focuses on the chronicity of cutaneous allergic diseases. It aims to determine the mechanisms that govern the differentiation and long-term maintenance of distinct TRM subpopulations (CD8⁺ TRMs, CD4⁺ TRMs; TRMs producing type 1, type 2, or type 3/17 cytokines; and regulatory TRMs) that persist in the skin of patients with contact eczema, atopic dermatitis, and drug allergy.

Project 2 : Deciphering the role and mechanisms of neuroinflammation in the severity of severe drug allergies - Coordination: Marie Tauber.

Project 2 focuses on the pathophysiology of drug allergies. It aims to determine the mechanisms by which sensory neurons (nociceptors) that innervate the skin initiate or amplify the extensive epidermal detachment that characterizes patients suffering from toxic epidermal necrolysis.

ProjeCt 3 : Role of MAIT cells in the pathogenesis and severity of hidradenitis suppurativa - Coordination: Axel Villani.

Project 3 focuses on the complex pathogenesis of hidradenitis suppurativa. One of the project’s objectives is to better understand the mechanisms by which a particular subtype of lymphocytes, MAIT cells (mucosal-associated invariant T cells), contribute to controlling bacteria that infiltrate the skin lesions of patients suffering from hidradenitis suppurativa.

Project 4 : Clinical and translational research - Coordination: Audrey Nosbaum.

Project 4 brings together several clinical and translational studies that we are currently conducting in the field of inflammatory and allergic skin diseases.