VRS Lyon Study Group
This Lyon-based working group on Respiratory Syncytial Virus (RSV study group in Lyon), coordinated by Dr Jean-Sébastien CASALEGNO, was created in 2017. This independent, multidisciplinary working group brings together field experts and national experts who are pursuing an ambitious research programme on respiratory viruses in children, including RSV, hMPV and rhinoviruses.
The aim of this group is to measure the impact of these infections on public health, identify the populations most at risk, measure the effectiveness of preventive measures put in place, and understand the dynamics of the circulation of these pathogens in our urban population. To this end, the group brings together paediatricians, virologists, researchers, intensive care specialists, infectious disease specialists, emergency physicians, urban planners, health data experts and qualitative research experts. By combining these complementary data and multidisciplinary expertise, we are able to carry out innovative collaborative projects in environmental health that will enable us to better understand the impact of the urban environment and climate on the dynamics of virus transmission and the burden of respiratory infections in children.
Recent publications
Horvat C, Duclaux-Loras L, Ouziel A, Butin M, Couray-Targe S, Myard-Dury AF, Haesebaert J, Massoud M, Benchaib M, Ploin A, Gillet Y, Lina B, Casalegno JS, Ploin D; VRS Study Group in Lyon. Heterogeneity of Clinical Phenotypes in Severe Acute Respiratory Infections due to Respiratory Syncytial Virus: A Need to Look Beyond Hospitalization. J Pediatr. 2024 Dec 12:114441. doi: 10.1016/j.jpeds.2024.114441. Epub ahead of print. PMID: 39674538.
Cong B, Koç U, Bandeira T, Bassat Q, Bont L, Chakhunashvili G, Cohen C, Desnoyers C, Hammitt LL, Heikkinen T, Huang QS, Markić J, Mira-Iglesias A, Moyes J, Nokes DJ, Ploin D; VRS study group in Lyon; Seo E, Singleton R, Wolter N, Fu Yung C, Zar HJ, Feikin DR, Sparrow EG; Respiratory Virus Global Epidemiology Network; Nair H, Li Y; PROMISE investigators. Changes in the global hospitalisation burden of respiratory syncytial virus in young children during the COVID-19 pandemic: a systematic analysis. Lancet Infect Dis. 2024 Apr;24(4):361-374. doi: 10.1016/S1473-3099(23)00630-8. Epub 2023 Dec 20. PMID: 38141633.
Casalegno JS, Bents S, Paget J, Gillet Y, Ploin D, Javouhey E, Lina B, Morfin F, Grenfell BT, Baker RE; VRS study group in Lyon. Application of a forecasting model to mitigate the consequences of unexpected RSV surge: Experience from the post-COVID-19 2021/22 winter season in a major metropolitan centre, Lyon, France. J Glob Health. 2023 Feb 3;13:04007. doi: 10.7189/jogh.13.04007. PMID: 36757127.
Jourdain M, Benchaib M, Ploin D, Gillet Y, Javouhey E, Horvat C, Massoud M, Butin M, Claris O, Lina B, Casalegno JS On Behalf Of The VRS Study Group In Lyon. Identifying the Target Population for Primary Respiratory Syncytial Virus Two-Step Prevention in Infants: Normative Outcome of Hospitalisation Assessment for Newborns (NOHAN). Vaccines (Basel). 2022 May 6;10(5):729. doi: 10.3390/vaccines10050729. PMID: 35632484; PMCID: PMC9147066.