Projets "intra-muros" CIRI
Initiés peu après la fondation du Centre comme moyen de mettre en œuvre notre politique scientifique, le programme de projets intra-muros du CIRI vise à encourager les efforts de collaboration entre les groupes du CIRI sur tous les aspects de la recherche, en mettant l'accent sur la recherche fondamentale, translationnelle ou technologique et le développement.
Suite un appel d'offre interne, des projets sont soutenus sous la forme de subventions d'amorçage pour une durée d'un an.
Depuis le lancement du programme en 2015, plusieurs projets ont bénéficié du label intra-muros CIRI. La plupart d'entre eux ont abouti à des publications et/ou maturé jusqu'à l'obtention de financements externes.
Liste de projets subventionnés:
2024
Établir des organoïdes des voies respiratoires inférieures humaines
- Collaboration entre le Groupe Persist et les chercheurs travaillant sur la Tuberculose (Dr. Oana Dumitrescu) au sein de l'equipe StaPath
Cultures organotypiques CIRIennes de foie humain (CIRI-hOLiC)
- Collaboration entre le groupe Nitrovire et les équipes HepVir et VIRIMI
2023
Deciphering the molecular architecture of the transcription complex of vesicular stomatitis virus by cryo electron tomography
- Collaboration between the IbIV team and Riedel
Molecular bases of filovirus RNA recognition by intracellular sensors
- Collaboration between the UBIVE and BMPV teams
2021
Ex vivo organ cultures for testing innovative antivirals against SARS-CoV-2 and Nipah virus
- Collaboration between the IbIV and VIRIMI teams
Bacteria-eating amoebae to help treat skin infections
- Collaboration between the Horigene and EIA teams
Impact of HPV38 E6/E7 oncoproteins on the immune response to allergens
- Collaboration between the ICL and EIA teams
2020
Development of Cecal ligation and puncture (CLP) mouse sepsis model
- Collaboration between the NLRP3 and NOPAB teams
Deciphering interactions between metabolic pathways and the innate antiviral response: a first proof of concept with the Hepatitis B virus
- Collaboration between the HepVir and VIRIMI teams
2019
Autophagy and maturation statuses in human primary dendritic cells upon HTLV-1 infection
- Collaboration between the APY and OR teams
Virus-Natural Killer cell repertoire interaction
- Collaboration between the LYACTS and Lp2L teams
2018
The lung-on-a-chip as a new platform for studying respiratory diseases
- Collaboration between the LegioPath, VirPath Stapath teams
Single-cell response in space
- Collaboration between the NOPAB and EIA teams
Generation of a new congenic mouse to improve HSC engraftment and adoptive cell transfer experiments: the B6.1/CIRI mouse
- Collaboration between the ICL and LYACTS teams
Analyzing centrosomal alterations by oncogenic viruses using proximity-dependent Biotin Identification
- Collaboration between the groups OR team and researchers working on EBV
2017
Study of the effect of fusion inhibitory peptides in the prevention and treatment of Influenza virus infection
- Collaboration between the IbIV and VirPath teams
2016
Development of Crispr/cas9 genome‐wide screens in primary cells: Understanding the macrophage‐NK cells cross‐talk during intracellular bacterial infections
- Collaboration between the LYACTS, I2BA and EVIR teams
Implementing Single cell RNA-seq at the CIRI
- Collaboration between the REVE and ICL teams
Tn-seq: Comprehensive genetics of host-pathogen interaction and acquired resistance
- Collaboration between the Horigene, LegioPath and Stapath teams
2015
Implementing research on Ebola virus at the CIRI
- Collaboration between the BMPV, REVE and VIV teams
Implementing research on Crimean Congo Hemorrhagic Fever virus (CCHF) at the CIRI
- Collaboration between the IbIV, APY, EVIR, REVE and Fondation Mérieux teams