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Funded for the year 2021

Bacteria-eating amoebae to help treat skin infections

Collaboration between the groups Horigene and EIA

The increasing resistance of bacterial pathogens to antibiotics is a major public health concern. The World Health Organization (WHO) has issued a priority list of 12 bacterial pathogens for which new therapeutic strategies are urgently needed. This intramural CIRI project will investigate the potential of free-living amoebae to predate and eliminate antibiotic resistant bacteria associated with skin diseases. By feeding on bacteria, these professional phagocytes, can clear large bacterial populations. The general objective of this collaborative project is to evaluate the potential of selected amoeba for therapeutic intervention on skin infections by studying their behaviour and the inflammatory response in cellular models, on skin explants and on mouse skin. The project will leverage on the expertise of the team “Horizontal Gene Transfer In Bacterial Pathogens” (Xavier Charpentier) who has selected amoeba with broad-spectrum bactericidal activity against the WHO priority list pathogens and the team “Immunology Of Skin Allergy And Vaccination” (Marc Vocanson and Jean-François Nicolas), a leading expert in skin physiology, inflammation and response to bacterial pathogens.

This unique collaboration will make it possible to study the feasibility of this new approach in the fight against antibiotic-resistant skin infections.

 

 

 

 

 

 

 

Bacteria-eating amoebas (green) navigates a monolayer of skin cells in search of their bacterial preys