Skip to content. | Skip to navigation

Personal tools

  • Le CIRI sur Linkedin
Sections

Managing bodies

logo Inserm      logo cnrslogo ENSL       logo ucb1


Secondary managing bodies

logo ENSL logo ucb1

You are here: Home / About us / Events / CIRI seminar: Pr. Eike STEINMANN

CIRI seminar: Pr. Eike STEINMANN

"Culturing Hepatitis E Virus– recent advances and novel perspectives for basic science and drug discovery"
When May 10, 2022
from 10:30 AM to 11:45 AM
Where visioconférence
Contact Name

Pr. Eike STEINMANN (Molecular and Medical Virology, Ruhr-University Bochum, Germany): "Culturing Hepatitis E Virus– recent advances and novel perspectives for basic science and drug discovery" .

Abstract:
Hepatitis E virus is the leading cause of liver cirrhosis and liver failure with increasing prevalence worldwide. The single-stranded RNA virus is predominantly transmitted by blood transfusions, inadequate sanitary conditions and contaminated food products. To date the off-label drug ribavirin (RBV) is the treatment of choice for many patients. Nonetheless, a specific HEV treatment remains to be identified. So far, the knowledge about the HEV life cycle and pathogenesis has been severely hampered because of the lack of an efficient HEV cell culture system. In this presentation a method and its characterization will be presented to produce high titers of non-enveloped and enveloped HEV particles. Using this cell culture system, different novel findings with respect to HEV entry, replication and assembly as well as drug design strategies will be shown.

Contact : Marlène DREUX -   marlene.dreux@ens-lyon.fr
Filed under: