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Vous êtes ici : Accueil / CIRI / Evenements / Séminaire CIRI (12.09.2023) : Dr Maria Tovar

Séminaire CIRI (12.09.2023) : Dr Maria Tovar

"The sources of antigenic peptides for the MHC class I pathway"
Quand ? Le 12/09/2023,
de 11:00 à 12:00
Où ? Amphi Pasteur
S'adresser à Branka Horvat

Dr Maria Tovar, Institut National de la Santé et de la Recherche U1131, Institut de Génétique Moléculaire, Université Paris 7 75010, Paris, France: " The sources of antigenic peptides for the MHC class I pathway "


Abstract: Comprehension of Major histocompatibility class I (MHC-I) antigen presentation would contribute to the understanding of viral and cancer immune evasion as well as possible immuno-modulator mechanisms to aggregate related diseases. We focused on two different sources of antigenic peptides: study of autophagy as a protein degradative mechanism to produce antigenic peptides, and characterization of the translation complex synthesizing antigenic peptides before mRNA splicing. We uncovered that aggregate-prone glutamine and the Epstein Barr Virus-encoded EBNA1 proteins were not processed by autophagy to produce antigenic peptides while ovalbumin-free protein was. In addition, we observed pre-spliced mRNA antigenic sequence in light polysome fraction as well as the interaction between ribosomal protein L5 (RPL5) with antigenic peptide sequence from pre-spliced mRNAs.


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