Aller au contenu. | Aller à la navigation

Outils personnels

  • Le CIRI sur Linkedin


logo Inserm      logo cnrslogo ENSL       logo ucb1

Tutelles secondaires

logo ENSL logo ucb1

Vous êtes ici : Accueil / Le Centre / Evenements / Séminaire CIRI (10.10.2023) : Pr. Roberto CATTANEO

Séminaire CIRI (10.10.2023) : Pr. Roberto CATTANEO

 « A lethal genome collective : brain tropism acquisition by measles virus »
Quand ? Le 10/10/2023,
de 11:00 à 12:00
Où ? Amphi Pasteur
S'adresser à Mathieu Mateo

Pr. Roberto CATTANEO, (Professor of Biochemistry and Molecular Biology Mayo Clinic – Rochester – Minnesota - USA;  « A lethal genome collective : brain tropism acquisition by measles virus »


Abstract: It is increasingly appreciated that pathogens can spread as collective infectious units. Brain autopsy material from a patient who died with subacute sclerosing panencephalitis (SSPE) provided a unique opportunity to reconstruct the evolution of an RNA genome collective in a human brain. Multiple distinct genome lineages co-replicated even at the level of single cells. Driver mutations were independently and recurrently selected across brain regions and genetic backgrounds. Specific mutations were constrained to intermediate prevalence by frequency-dependent selection, which modulated fusogenicity. Analyses of this and other SSPE brains indicate that plastically evolving genome collectives are key for measles virus brain colonization and raise profound questions about the importance of genome collectives in human disease more broadly.

Mots-clés associés :