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News
Dec 05, 2025 Publication of the I2BA team in The Journal of Experimental Medicine
Dec 01, 2025 International Call for the Recruitment of an Early-Career Team Leader in Virology at CIRI.
Nov 19, 2025 Alexandre Legrand, Rémi Demeure, Amandine Chantharath, Carine Rey, Julie Baltenneck, Cameron L. M. Gilchrist, Joana L. Rocha, Clara Loyer, Léa Picard, Andrea Cimarelli, Martin Steinegger, Francois Rousset, Peter H. Sudmant and Lucie Etienne
Nov 03, 2025 Two recent papers, resulting from international collaborations between Bénédicte PY, DR INSERM, NLRP3 Team, and BioAge Labs in the US, R. Coll in Ireland, M. Geyer in Germany, and R. Karki in Korea, are featured in a joint highlight in Nature Reviews Drug Discovery: www.nature.com/articles/d41

Understanding infectious diseases to better control them

The Centre International de Recherche en Infectiologie (CIRI) is a joint research unit of the Lyon 1 University, Inserm, CNRS and the ENS de Lyon in partnership with VetAgro Sup, the Institut Pasteur and the Hospices Civils de Lyon. The CIRI gathers the scientific and medical research communities with complementary disciplinary backgrounds grouped in 3 specialties working together with the objective to understand host-microbe interactions to better fight infectious diseases.

Discover the CIRI: General presentation, Teams, Teaching, Clinical research, Organization, The 3 specialties and Transversal projects, Jobs and internship offers, Contact & Localization.

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Publications

Articles

Nov 19, 2025 Evolutionary characterization of antiviral SAMD9/9L across kingdoms supports ancient convergence and lineage-specific adaptations

Alexandre Legrand, Rémi Demeure, Amandine Chantharath, Carine Rey, Julie Baltenneck, Cameron L. M. Gilchrist, Joana L. Rocha, Clara Loyer, Léa (...)

Oct 16, 2025 Urban environment and RSV: a retrospective observational study of neighbourhood factors associated with the risk of severe disease in the infant population of a metropolitan area, Lyon, France

Publications of RSV Study Group Lyon

Sep 22, 2025 Interleukins 15 and 18 synergistically prime the antitumor function of natural killer cells through noncanonical activation of mTORC1

Natural killer (NK) cells have antitumor activity that is primed by IL-15 and IL-18, components of a cytokine cocktail used in NK cell–based cancer (...)

Revues

Nov 03, 2025 International collaborations: 2 papers are featured in a joint highlight in Nature Reviews

Two recent papers, resulting from international collaborations between Bénédicte PY, DR INSERM, NLRP3 Team, and BioAge Labs in the US, R. Coll in (...)

May 12, 2025 TRIM proteins: A ‘swiss army knife’ of antiviral immunity

Chabot et al., Plos Pathogens, 2025 / Team HepVir

Mar 24, 2023 Covid-19: infection-vaccination combination best protects against reinfection with SARS-CoV-2

Several CIRI teams carried out this work, published in the journal Science Translational Medicine.

 
Agenda

Seminars

Dec 09, 2025 séminaire CIRI : Mathias PERCIPALLE (09.12.2025)

“ Structure par cryoEM des virions HTLV-1 présent dans le biofilm viral ”

Dec 17, 2025 séminaire CIRI : Pr. Miles W CARROLL (17.12.2025)

“ EBOV : Outbreaks, molecular epidemiology, immunity, persistence and surveillance ”

Last conferences

Dec 04, 2025 2025 Annual meeting of the French Dendritic Cell Society (CFCD)

Helena Paidassi will be at the Curie Institute on December 4 and 5 to present her research findings (...)

Nov 07, 2025 Symposium of the French Network on Monocytes-Macrophages

Le huitième Symposium du réseau francais monocytes/macrophages aura lieu à Lyon le 7 novembre (...)

Sep 18, 2022 Congrès International HBV 2022

Biologie des virus des hépatites B et D

Jun 15, 2022 IRCI 2022

Immune Response in Cancer and Infection

Jun 07, 2022 Réunion annuelle AC42

Réseau National Hépatites de l'ANRS | Maladies Infectieuses Emergentes

Last events

Aug 31, 2024 2024 CNRS conferences on a boat

Embark with a scientist for a surprise and confidential mini-conference, in the form of a boat trip (...)

Feb 04, 2024 "Têtes chercheuses": research in cancerology, presented by the fondation ARC

The ARC Foundation brings together 5 leading cancer researchers for a 45-minute program. It will (...)

Thesis defenses

Dec 11, 2025 Sylvère Bastien defense thesis, team StaPath (2025.12.11)

Bacterial infections and microbial interactions: omics studies of Staphylococcus aureus and (...)