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Evolutionary characterization of antiviral SAMD9/9L across kingdoms supports ancient convergence and lineage-specific adaptations
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Alexandre Legrand, Rémi Demeure, Amandine Chantharath, Carine Rey, Julie Baltenneck, Cameron L. M. Gilchrist, Joana L. Rocha, Clara Loyer, Léa Picard, Andrea Cimarelli, Martin Steinegger, Francois Rousset, Peter H. Sudmant and Lucie Etienne
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Urban environment and RSV: a retrospective observational study of neighbourhood factors associated with the risk of severe disease in the infant population of a metropolitan area, Lyon, France
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Publications of RSV Study Group Lyon
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B. Lina group
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CARVI (O. Terrier/S. Trouillet-Assant)
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Interleukins 15 and 18 synergistically prime the antitumor function of natural killer cells through noncanonical activation of mTORC1
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Natural killer (NK) cells have antitumor activity that is primed by IL-15 and IL-18, components of a cytokine cocktail used in NK cell–based cancer immunotherapy. Fallone et al. found that IL-15 and IL-18 synergized to activate the complex mTORC1, which resulted in increased proliferation and function of both mouse and human NK cells. IL-15 and IL-18 stimulated mTORC1 activity through distinct pathways not previously implicated in its regulation. The combination of IL-15 and IL-18 improved the survival of mice engrafted with tumor cells, suggesting a therapeutic strategy to enhance the efficacy of NK cell–based cancer immunotherapy
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Lung virome convergence precedes hospital-acquired pneumonia in intubated critically ill patients
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Lung virome convergence precedes hospital-acquired pneumonia in intubated critically ill patients
Anani et al. Cell Rep Medicine - Team VirPath-CARVI
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Pivotal role of exogenous pyruvate in human natural killer cell metabolism
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Nicolas Kern Coquillat, Louis Picq, Ameline Hamond, Pierre Megy, Sarah Benezech, Annabelle Drouillard, Nina Lager-Lachaud, Edern Cahoreau, Marielle Moreau, Lucie Fallone, Anne-Laure Mathieu, Floriant Bellvert, Carine Nizard, Anne-Laure Bulteau, Thierry Walzer, Antoine Marçais ///
Nature Metabolism, 2025 Jan 3
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Impaired mucosal IgA response in patients with severe COVID-19
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Yaugel-Novoa M, Noailly B, Jospin F, Pizzorno A, Traversier A, Pozzetto B, Waeckel L, Longet S, Pillet S, Botelho-Nevers E, Rosa-Calatrava M, Bourlet T, Paul S. Emerg Microbes Infect. 2024. doi:10.1080/22221751.2024.2401940
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Canine mesenteric lymph nodes (MLNs) characterization by sc-RNAseq: insights compared to human and mouse MLNs
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Chamorro B.M., Hameed S.A., Claude J-B, Piney L., Chapat L., Swaminathan G., Poulet H., De Luca K., Mundt E., Paul S. Sci Rep. 2024. doi: 10.1038/s41598-024-71310-9.
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Vaccines and monoclonal antibodies to prevent healthcare-associated bacterial infections
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Sauvat L., Verhoeven P.O., Gagnaire J., Berthelot P., Paul S., Botelho-Nevers E., Gagneux-Brunon A. Clin Microbiol Rev. doi :10.1128/cmr.00160-22
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Tumor-induced natural killer cell dysfunction is a rapid and reversible process uncoupled from the expression of immune checkpoints
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Kévin Pouxvielh, Marie Marotel, Annabelle Drouillard, Marine Villard, Marion Moreews, Anna Bossan, Mathilde Poiget, Liliane Khoryati,Sarah Benezech, Lucie Fallone, Sarah Hamada, Noémi Rousseaux, Louis Picq, Yamila Rocca, Aurore Berton, Marine Teixeira,
Anne- Laure Mathieu, Michelle Ainouze, Uzma Hasan, Alain Fournier, Olivier Thaunat, Antoine Marçais, Thierry Walzer /
Science Advances , 2024, Aug 28
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Haploinsufficiency in PTPN2 leads to early-onset systemic autoimmunity from Evans syndrome to lupus
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Marie Jeanpierre, Jade Cognard, Maud Tusseau, ... Thierry Walzer, Frédéric Rieux-Laucat, Alexandre Belot, and Anne-Laure Mathieu ; J Exp Med 2024 Sep 2;221(9):e20232337. doi: 10.1084/jem.20232337.
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