Understanding infectious diseases to better control them
The CIRI (Centre International de Recherche en Infectiologie) brings together the scientific and medical research communities in infectious diseases and immunity in the Lyon-St Etienne area, with the University of Lyon 1, Inserm, CNRS and ENS de Lyon as main managing bodies, and Hospices Civils de Lyon and Université Jean Monnet as secondary managing bodies, and important partnerships with VetAgroSup and Institut Pasteur. More than 400 researchers with complementary disciplinary backgrounds are grouped into 3 main departments: immunologists, bacteriologists and virologists, some of them being as well as cancerologists and epidemiologists. They work together with the main objective of understanding the biology of microbes and the immune system, and the interactions between microbes and their hosts, in order to better combat infectious diseases and other illnesses involving the immune system.
- Three departments working together
Découvrir le CIRI
- Publications
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Publications of RSV Study Group Lyon
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Natural killer (NK) cells have antitumor activity that is primed by IL-15 and IL-18, components of a cytokine cocktail used in NK cell–based cancer immunotherapy. Fallone et al. found that IL-15 and IL-18 synergized to activate the complex mTORC1, which resulted in increased proliferation and function of both mouse and human NK cells. IL-15 and IL-18 stimulated mTORC1 activity through distinct pathways not previously implicated in its regulation. The combination of IL-15 and IL-18 improved the survival of mice engrafted with tumor cells, suggesting a therapeutic strategy to enhance the efficacy of NK cell–based cancer immunotherapy
- Lung virome convergence precedes hospital-acquired pneumonia in intubated critically ill patients Anani et al. Cell Rep Medicine - Team VirPath-CARVI
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Pastor et al., Plos One, 2024 / Team HepVir
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Pastor et al., Frontiers Mircrobiology, 2024 / Team HepVir
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Nicolas Kern Coquillat, Louis Picq, Ameline Hamond, Pierre Megy, Sarah Benezech, Annabelle Drouillard, Nina Lager-Lachaud, Edern Cahoreau, Marielle Moreau, Lucie Fallone, Anne-Laure Mathieu, Floriant Bellvert, Carine Nizard, Anne-Laure Bulteau, Thierry Walzer, Antoine Marçais /// Nature Metabolism, 2025 Jan 3
- News
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Two recent papers, resulting from international collaborations between Bénédicte PY, DR INSERM, NLRP3 Team, and BioAge Labs in the US, R. Coll in Ireland, M. Geyer in Germany, and R. Karki in Korea, are featured in a joint highlight in Nature Reviews Drug Discovery: www.nature.com/articles/d41
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Peter Sudmant (UC Berkeley, USA), David Enard (Univ. Arizona, USA) and Lucie Etienne (CIRI, CNRS / ENS Lyon, France) are inviting you to register for the “Host adaptations to viral infections” Meeting that they are organizing from May 10th to May 13th 2026.
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Le CIRI compte 12 projets qui ont été retenus pour un financement dans le cadre de l'appel à projets générique ANR 2025. Nous vous en faisons découvrir les détails ici.
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Le CIRI participera à la conférence annuelle du Musée de Sciences Biologiques Docteur Mérieux à l'occasion de la Fête de la Science.
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A l'occasion de reportages en immersion dans le Centre Hospitalier de Lyon, le professeur Axel Villani s'exprime sur cette pathologie méconnue dans deux vidéos destinées aux professionnels.
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Le Conseil européen de la recherche (ERC) a annoncé les lauréats 2025 de la bourse "Starting Grant". François Rousset (GenoMics) a obtenu avec succès cette bourse dédiée aux jeunes chercheurs et chercheuse portant des projets d'excellence, avec son projet "Conservation of defense and anti-defense mechanisms across the tree of life" (CODA).
- Job offers
- The HEAL team is seeking for a PhD candidate to start a research project on the cellular and molecular aspects of “Orthonairovirus: molecular determinants of transmission”
- The VIRPATH laboratory at the International Center for Research in Infectiology (CIRI) is inviting applications from motivated, independent postdoctoral researchers to lead cutting-edge projects foc (...)
- L’équipe dirigée par Olivier Thaunat recrute un·e ingénieur·e en Immunologie dans le cadre d’un projet ANR portant sur les mécanismes d’allo-reconnaissance en transplantation
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PERSIST Lab - Nicolas Personnic
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Post-doc offer at the CERP (Center of Excellence in Respiratory Pathogens)
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PERSIST Lab - Nicolas Personnic
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To heighten its projects on the molecular and cellular virology of the Crimean-Congo hemorrhagic fever virus (CCHFV), HEAL, the Hepatotropic & Emerging Agents Laboratory is seeking to recruit: - A (...)
- A PhD under a "CIFRE convention" is opened in EIA team. It will start in September 2024.
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EVIR Team: "Genetic reprogramming of B cells to enhance their therapeutic properties before autologous transfer"
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A 2-year post-doctoral position for a highly motivated and talented postdoctoral fellow is available in the team of Dr Marc Vocanson at the Centre International de Recherche en Infectiologie (CIRI), (...)
- Agenda
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2025 Annual meeting of the French Dendritic Cell Society (CFCD)
Helena Paidassi will be at the Curie Institute on December 4 and 5 to present her research findings (...)
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Symposium of the French Network on Monocytes-Macrophages
Le huitième Symposium du réseau francais monocytes/macrophages aura lieu à Lyon le 7 novembre (...)
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SYMPOLEGIO 2024
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NK/ILC symposium 2024 (16-18.10.24)
The NK/ILC symposium 2024 will take place at the amphithéatre Mérieux, Ecole Normale Supérieure, (...)
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Séminaire CIRI: Dr. Sami JANNIN (12.11.2025)
“ Vers une résonance magnétique 10000 fois plus sensible au service de la biologie ”
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Séminaire CIRI: Dr. Aileen ROWAN (06.11.2025)
“ Somatic mutations HTLV-1 carriers- early predictors of malignant transformation ”
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Soutenance de thèse de Chloé Teixeira, équipe StaPath (24/10/2025)
Impact des modifications post-transcriptionnelles des ARN sur la virulence de Staphylococcus aureus
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Soutenance de thèse de Mathias Carriou, équipe B.Lina (17/10/2025)
Interactions interrègnes : comment la levure Candida albicans module-t-elle la virulence de la (...)
