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You are here: Home / About us / Actualités / Covid-19: infection-vaccination combination best protects against reinfection with SARS-CoV-2

Covid-19: infection-vaccination combination best protects against reinfection with SARS-CoV-2

Several CIRI teams carried out this work, published in the journal Science Translational Medicine.

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See the article online: CNRS / Inserm


A large proportion of the population has developed immunity to SARS-CoV-2 following infection and/or vaccination. In addition, some infected patients benefit from a so-called "hybrid" immunity when they have been vaccinated after their infectious episode. Scientists from Inserm, CNRS, Claude-Bernard Lyon 1 University and ENS Lyon within the Centre International de Recherche en Infectiologie (CIRI) are seeking to characterize the imprint left by exposure to SARS-CoV-2 through vaccination or the combination of both events on immune memory. The objective? To better understand the mechanisms of the immune response to the virus in order to improve patient management and optimize vaccine strategies. In a new study, scientists compared the immune memory of convalescent individuals, both vaccinated and unvaccinated against SARS-CoV-2, with that induced by vaccination in vaccinated individuals who had never beeń infected with the virus. Their results show that individuals vaccinated after infection are best protected from reinfection with SARS-CoV-2. The full article is published in the journal Science Translational Medicine.

The article

Prior SARS-CoV-2 infection enhances and reshapes spike protein-specific memory induced by vaccination
Veronique Barateau, Loic Peyrot, Carla Saade, Bruno Pozzetto, Karen Brengel-Pesce, Mad-Helenie Elsensohn, Omran Allatif, Nicolas Guibert, Christelle Compagnon, Natacha Mariano, Julie Chaix, Sophia Djebali, Jean-Baptiste Fassier, Bruno Lina, Katia Lefsihane, Maxime Espi, Olivier Thaunat, Jacqueline Marvel, Manuel Rosa-Calatrava, Andres Pizzorno, Delphine Maucort-Boulch, Laetitia Henaff, Mitra Saadatian-Elahi, Philippe Vanhems, Stéphane Paul, Thierry Walzer, Sophie Trouillet-Assant, and Thierry Defrance
Science Translational Medicine, 15 mars 2023
DOI: 10.1126/scitranslmed.ade0550


CIRI teams involved