Séminaire CIRI (28.10.2024): Pr. Eric TARTOUR

Pr. Eric TARTOUR, (Head lab of immunology Bi-site Hopital Europeen Georges Pompidou and Hôpital Necker), « Role of resident memory T lymphocytes in anti-tumor vaccination and cancer immunotherapy »

Abstract:
Resident memory T lymphocytes (TRM) play a role in the immunosurveillance of T lymphocytes in tissues and are involved in the defence against infections and cancer. We have previously shown in preclinical models that they are essential in anti-cancer vaccine strategies, particularly for mucosal tumours where they can be induced by mucosal immunisation route. In cancers treated with immunotherapy protocols based on anti-PD-(L)1 antibodies, it has been demonstrated that intratumoral amplification of these TRM  is associated with clinical response. Recently, it has been reported  that these TRM, classically defined by the CD103 marker, are fairly heterogeneous and composed of different sub-populations expressing or not CD103 and defined by other markers such as CD69 and CD49 and a profile of transcription factors associated with TRM. The differential role of these TRM sub-populations in vaccination strategies or in the response to anti-PD-(L)1 treatment in humans will be the topic of this seminar.