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Evolutionary characterization of antiviral SAMD9/9L across kingdoms supports ancient convergence and lineage-specific adaptations
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Alexandre Legrand, Rémi Demeure, Amandine Chantharath, Carine Rey, Julie Baltenneck, Cameron L. M. Gilchrist, Joana L. Rocha, Clara Loyer, Léa Picard, Andrea Cimarelli, Martin Steinegger, Francois Rousset, Peter H. Sudmant et Lucie Etienne
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Le Centre
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Actualités
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Urban environment and RSV: a retrospective observational study of neighbourhood factors associated with the risk of severe disease in the infant population of a metropolitan area, Lyon, France
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Publications du RSV Study Group Lyon - Team VirPath-CARVI
Jaakkola K, Renard F, Roy A, Benchaib M, Metcalf J, Baker R, Simon B, Vecchi G, Ploin D, Gillet Y, Javouhey E, Lina B, Grenfell BT, Casalegno JS; VRS study group in Lyon. Urban environment and RSV: a retrospective observational study of neighbourhood factors associated with the risk of severe disease in the infant population of a metropolitan area, Lyon, France. BMC Public Health. 2025 Oct 14;25(1):3481
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B. Lina group
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Equipe CARVI (O. Terrier/S. Trouillet-Assant)
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Interleukins 15 and 18 synergistically prime the antitumor function of natural killer cells through noncanonical activation of mTORC1
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Natural killer (NK) cells have antitumor activity that is primed by IL-15 and IL-18, components of a cytokine cocktail used in NK cell–based cancer immunotherapy. Fallone et al. found that IL-15 and IL-18 synergized to activate the complex mTORC1, which resulted in increased proliferation and function of both mouse and human NK cells. IL-15 and IL-18 stimulated mTORC1 activity through distinct pathways not previously implicated in its regulation. The combination of IL-15 and IL-18 improved the survival of mice engrafted with tumor cells, suggesting a therapeutic strategy to enhance the efficacy of NK cell–based cancer immunotherapy
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Walzer T - LYACTS
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Actualités
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Lung virome convergence precedes hospital-acquired pneumonia in intubated critically ill patients
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Lung virome convergence precedes hospital-acquired pneumonia in intubated critically ill patients
Anani et al. Cell Rep Medicine - Team VirPath-CARVI
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B. Lina group
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Equipe CARVI (O. Terrier/S. Trouillet-Assant)
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The dual-specificity kinase DYRK1A interacts with the Hepatitis B virus genome and regulates the production of viral RNA
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Pastor et al., Plos One, 2024 / Team HepVir
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Durantel D - HepVir
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Quoi de neuf pour nous ?
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Deciphering the phospho-signature induced by hepatitis B virus in primary human hepatocytes
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Pastor et al., Frontiers Mircrobiology, 2024 / Team HepVir
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Durantel D - HepVir
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Quoi de neuf pour nous ?
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Pivotal role of exogenous pyruvate in human natural killer cell metabolism
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Nicolas Kern Coquillat, Louis Picq, Ameline Hamond, Pierre Megy, Sarah Benezech, Annabelle Drouillard, Nina Lager-Lachaud, Edern Cahoreau, Marielle Moreau, Lucie Fallone, Anne-Laure Mathieu, Floriant Bellvert, Carine Nizard, Anne-Laure Bulteau, Thierry Walzer, Antoine Marçais ///
Nature Metabolism, 2025 Jan 3
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Walzer T - LYACTS
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Mucosal nirsevimab levels in respiratory syncytial virus breakthrough bronchiolitis
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Pillet S, Cantais A, Noailly B, Jospin F, Zekre F, Boussetta-Charfi O, Chenafi-Adham S, Bourlet T, Fourati S, Paul S. Lancet Infect Dis. 2024. doi:10.1016/S1473-3099(24)00600-5.
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Paul S - GIMAP
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Actualités
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Impaired mucosal IgA response in patients with severe COVID-19
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Yaugel-Novoa M, Noailly B, Jospin F, Pizzorno A, Traversier A, Pozzetto B, Waeckel L, Longet S, Pillet S, Botelho-Nevers E, Rosa-Calatrava M, Bourlet T, Paul S. Emerg Microbes Infect. 2024. doi:10.1080/22221751.2024.2401940
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Paul S - GIMAP
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Actualités
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Canine mesenteric lymph nodes (MLNs) characterization by sc-RNAseq: insights compared to human and mouse MLNs
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Chamorro B.M., Hameed S.A., Claude J-B, Piney L., Chapat L., Swaminathan G., Poulet H., De Luca K., Mundt E., Paul S. Sci Rep. 2024. doi: 10.1038/s41598-024-71310-9.
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Paul S - GIMAP
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