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Funded for the year 2021

Impact of HPV38 E6/E7 oncoproteins on the immune response to allergens

The skin is in constant contact with its environment and is therefore constantly exposed to physical damage resulting from its interaction with microorganisms and environmental factors such as UV radiation or exposure to chemicals. Our project aims to understand how two environmental factors can interact to cause inflammatory skin pathology. Skin colonization by human papillomavirus (HPV), a virus widely distributed in humans, alters the skin's immune response in response to UV radiation and contributes to the development of skin carcinoma. The molecular mechanisms involved in this synergy can be studied in an original preclinical model, where the E6 / E7 genes of the virus are expressed in keratinocytes. We will use this model to study the impact of these viral proteins on the skin's response to chemicals that induce inflammatory pathologies. The demonstration of a synergy will pave the way for epidemiological studies in humans to determine whether certain types of HPV virus can promote the development of inflammatory skin pathologies.






Two examples of contact dermatitis caused by skin exposure to chemicals Nickel and  pPD.